When monolayer cultures of chick embryo cells were infected with the serotype of vesicular stomatitis virus at high input multiplicities, the synthesis of cellular RNA was rapidly inhibited. The stimulation of cellular DNA synthesis observed in control cells following medium replacement was also inhibited in the infected cells. These activities of vesicular stomatitis virus on the synthesis of cellular nucleic acids were quite resistant to u.v. irradiation, although no virus RNA synthesis was detected in the cells infected with u.v.-irradiated vesicular stomatitis virus. No stimulation of degradation of cellular nucleic acids was observed in cells treated with irradiated vesicular stomatitis virus.


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