Replacement of the herpes simplex virus type 1 Vmw175 DNA binding domain with its varicella-zoster virus counterpart results in a protein with novel regulatory properties that can support virus growth.

References

1. Allen K. E. 1993 A mutational analysis of the DNA binding domain ofthe herpessimplex virus immediate earlyprotein Vmw175 PhD thesis University of Glasgow, UK:
   [Google Scholar]
2. Baudoux L., Defechereux P., Schoonbroodt S., Merville M. P., Rentier B., Piette J. 1995; Mutational analysis of varicella zoster virus major immediate-early protein IE62. Nucleic Acids Research 23:1341–1349
   [Google Scholar]
3. Cabirac G. F., Mahalingam R., Wellish M., Gilden D. H. 1990; Trans-activation of viral tk promoters by proteins encoded by varicella zoster virus open reading frames 61 and 62. Virus Research 15:57–68
   [Google Scholar]
4. Cohen J. I., Heffel D., Seidel K. 1993; The transcriptional activation domain of varicella-zoster virus open reading frame 62 protein is not conserved with its herpes simplex virus homolog. Journal of Virology 67:4246–4251
   [Google Scholar]
5. Conner J., Furlong J., Murray J., Meighan M., Cross A., Marsden H., Clements J. B. 1993; Herpes simplex virus type 1 ribonucleotide reductase large subunit: regions of the protein essential for subunit interaction and dimerisation. Biochemistry 32:13673–13680
   [Google Scholar]
6. DeLuca N. A., Schaffer P. A. 1985; Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4. Molecular and Cellular Biology 5:1997–2008
   [Google Scholar]
7. DeLuca N. A., Schaffer P. A. 1988; Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4. Journal of Virology 62:732–743
   [Google Scholar]
8. Desai P., Ramakrishnan R., Lin Z. W., Osak B., Glorioso J., Levine M. 1993; The RR1 gene of herpes simplex virus type 1 is uniquely transactivated by ICP0 during infection. Journal of Virology 67:6125–6135
   [Google Scholar]
9. DiDonato J. A., Spitzner J. R., Muller M. T. 1991; A predictive model for DNA recognition by the herpes simplex virus protein ICP4. Journal of Molecular Biology 219:451–470
   [Google Scholar]
10. Disney G. H., Everett R. D. 1990; A herpes simplex virus type 1 recombinant with both copies of the Vmw175 coding sequences replaced by the homologous varicella-zoster virus open reading frame. Journal of General Virology 71:2681–2689
    [Google Scholar]
11. Disney G. H., McKee T. A., Preston C. M., Everett R. D. 1990; The product of varicella-zoster virus gene 62 autoregulates its own promoter. Journal of General Virology 71:2999–3003
    [Google Scholar]
12. Everett R. D. 1984; Transactivation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity. EMBO Journal 13:3135–3141
    [Google Scholar]
13. Everett R. D. 1986; The products of herpes simplex virus type 1 (HSV-1) immediate early genes 1, 2 and 3 can activate HSV-1 gene expression in trans . Journal of General Virology 67:2507–2513
    [Google Scholar]
14. Everett R. D., Paterson T., Elliott M. 1990; The major transcriptional regulatory protein of herpes simplex virus type 1 includes a protease resistant DNA binding domain. Nucleic Acids Research 18:4579–4585
    [Google Scholar]
15. Everett R. D., Elliott M., Hope G., Orr A. 1991; Purification of the DNA binding domain of herpes simplex virus type 1 immediate-early protein Vmw175 as a homodimer and extensive mutagenesis of its DNA recognition site. Nucleic Acids Research 19:4901–4908
    [Google Scholar]
16. Everett R. D., DiDonato J., Elliott M., Muller M. 1992; Herpes simplex virus type 1 polypeptide ICP4 bends DNA. Nucleic Acids Research 20:1229–1233
    [Google Scholar]
17. Everett R. D., Cross A., Orr A. 1993; A truncated form of herpes simplex virus type 1 immediate-early protein Vmw110 is expressed in a cell type dependent manner. Virology 197:751–756
    [Google Scholar]
18. Faber S. W., Wilcox K. W. 1986; Association of the herpes simplex virus regulatory protein ICP4 with specific nucleotide sequences in DNA. Nucleic Acids Research 14:6067–6083
    [Google Scholar]
19. Felser J. M., Kinchington P. R., Inchauspe G., Straus S. E., Ostrove J. M. 1988; Cell lines containing varicella-zoster virus open reading frame 62 and expressing the ‘IE’ 175 protein complement ICP4 mutants of herpes simplex virus type 1. Journal of Virology 62:2076–2082
    [Google Scholar]
20. Fields B. N., Knipe D. M., Howley P. M. editor 1996 Fields Virology, 3rd edn. Philadelphia: Lippincott-Raven;
    [Google Scholar]
21. Flanagan W. M., Papavassiliou A. G., Rice M., Hecht L. B., Silverstein S., Wagner E. K. 1991; Analysis of the herpes simplex virus type 1 promoter controlling the expression of UL38, a true late gene involved in capsid assembly. Journal of Virology 65:769–786
    [Google Scholar]
22. Gu B., DeLuca N. A. 1994; Requirements for activation of the herpes simplex virus glycoprotein C promoter in vitro by the viral regulatory protein, ICP4. Journal of Virology 68:7953–7965
    [Google Scholar]
23. Gu B., Kuddus R., DeLuca N. A. 1995; Repression of activator- mediated transcription by herpes simplex virus ICP4 via a mechanism involving interactions with the basal transcription factors TATA-binding protein and TFIIB. Molecular and Cellular Biology 15:3618–3626
    [Google Scholar]
24. Imbalzano A. N., Shepard A. A., DeLuca N. A. 1990; Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene. Journal of Virology 64:2620–2631
    [Google Scholar]
25. Inchauspe G., Ostrove J. M. 1989; Differential regulation by varicella-zoster virus (VZV) and herpes simplex virus type-1 transactivating genes. Virology 173:710–714
    [Google Scholar]
26. Koop K. E., Duncan J., Smiley J. R. 1993; Binding sites for the herpes simplex virus immediate-early protein ICP4 impose an increased dependence on viral DNA replication on simple model promoters located in the viral genome. Journal of Virology 67:7254–7263
    [Google Scholar]
27. Kuddus B., Gu B., DeLuca N. A. 1995; Relationship between TATA-binding protein and herpes simplex virus type 1 ICP4 DNA-binding sites in complex formation and repression of transcription. Journal of Virology 69:5568–5575
    [Google Scholar]
28. McGeoch D. J., Dolan A., Donald S., Brauer D. H. K. 1986; Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1. Nucleic Acids Research 14:1727–1764
    [Google Scholar]
29. Michael N., Roizman B. 1989; Binding ofthe herpes simplex virus major regulatory protein to viral DNA. Proceedings of the National Academy of Sciences, USA 86:9808–9812
    [Google Scholar]
30. Michael N., Roizman B. 1993; Repression of the herpes simplex virus 1 alpha 4 gene by its gene product occurs within the context of the viral genome and is associated with all three identified cognate sites. Proceedings of the National Academy of Sciences, USA 90:2286–2290
    [Google Scholar]
31. Michael N., Spector D., Mavromara-Nazos P., Kristie T. M., Roizman B. 1988; The DNA-binding properties of the major regulatory protein alpha 4 of herpes simplex viruses. Science 239:1531–1534
    [Google Scholar]
32. Muller M. T. 1987; Binding of the herpes simplex virus immediate-early gene product ICP4 to its own transcription start site. Journal of Virology 61:858–865
    [Google Scholar]
33. O’Hare P., Hayward G. S. 1985; Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation. Journal of Virology 56:723–733
    [Google Scholar]
34. Paterson T., Everett R. D. 1988a; Mutational dissection of the HSV-1 immediate-early protein Vmw175 involved in transcriptional transactivation and repression. Virology 166:186–196
    [Google Scholar]
35. Paterson T., Everett R. D. 1988b; The regions of the herpes simplex virus type 1 immediate early protein Vmw175 required for site specific DNA binding closely correspond to those involved in transcriptional regulation. Nucleic Acids Research 16:11005–11025
    [Google Scholar]
36. Paterson T., Everett R. D. 1990; A prominent serine-rich region in Vmw175, the major transcriptional regulator protein of herpes simplex virus type 1, is not essential for virus growth in tissue culture. Journal of General Virology 71:1775–1783
    [Google Scholar]
37. Perera L. P., Mosca J. D., Ruyechan W. T., Hayward G. S., Straus S. E., Hay J. 1993; A major transactivator of varicella-zoster virus, the immediate-early protein IE62, contains a potent N-terminal activation domain. Journal of Virology 67:4474–4483
    [Google Scholar]
38. Roberts M. S., Boundy A., O’Hare P., Pizzorno M. C., Ciufo D. M., Hayward G. S. 1988; Direct correlation between a negative auto-regulatory response element at the cap site of the herpes simplex virus type 1 IE175 (alpha 4) promoter and a specific binding site for the IE175 (ICP4) protein. Journal of Virology 62:4307–4320
    [Google Scholar]
39. Schenk P., Ludwig H. 1988; The 65 kd DNA binding protein appears early in HSV-1 infection. Archives of Virology 102:119–123
    [Google Scholar]
40. Shepard A. A., Imbalzano A. N., DeLuca N. A. 1989; Separation of primary structural components conferring autoregulation, transactivation, and DNA-binding properties to the herpes simplex virus transcriptional regulatory protein ICP4. Journal of Virology 63:3714–3728
    [Google Scholar]
41. Showalter L. D., Zweig M., Hampar B. 1981; Monoclonal antibodies to herpes simplex type 1 proteins including the immediate- early protein ICP4. Infection and Immunity 34:684–692
    [Google Scholar]
42. Smiley J. R., Johnson D. C., Pizer L. I., Everett R. D. 1992; The ICP4 binding sites in the herpes simplex virus type 1 glycoprotein (gD) promoter are not essential for efficient gD transcription during virus infection. Journal of Virology 66:623–631
    [Google Scholar]
43. Smith C. A., Bates P., Rivera-Gonzalez R., Gu B., DeLuca N. 1993; ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB. Journal of Virology 67:4676–4687
    [Google Scholar]
44. Tyler J. K., Everett R. D. 1993; The DNA binding domain of the varicella-zoster virus gene 62 protein interacts with multiple sequences which are similar to the binding site of the related protein of herpes simplex virus type 1. Nucleic Acids Research 21:513–522
    [Google Scholar]
45. Tyler J. K., Allen K. E., Everett R. D. 1994; Mutation of a single lysine residue severely impairs the DNA recognition and regulatory functions of the VZV gene 62 transactivator protein. Nucleic Acids Research 22:270–278
    [Google Scholar]
46. Wu C. L., Wilcox K. W. 1990; Codons 262 to 490 from the herpes simplex virus ICP4 gene are sufficient to encode a sequence-specific DNA binding protein. Nucleic Acids Research 18:531–538
    [Google Scholar]
47. Wu C. L., Wilcox K. W. 1991; The conserved DNA-binding domains encoded by the herpes simplex virus type 1 ICP4, pseudorabies virus IE180, and varicella-zoster virus ORF62 genes recognize similar sites in the corresponding promoters. Journal of Virology 65:1149–1159
    [Google Scholar]