1887

Abstract

We analysed by ELISA a total of 478 human sera for the presence of antibodies to HPV-11 virus-like particles. The sera were obtained from patients with current genital warts (group CO), from males attending the hospital for fertility disorders (group MA), from blood donors (group BD) and from patients hospitalized for reasons unrelated to HPV infections (group HO). Antibody prevalence was higher in male patients of group CO (23.0%) as compared to males of groups MA (3.2%; < 0.0001), HO (5.3%; = 0.01) and BD (16.7%; ). In addition, there was a significant difference in antibody titre between the males of group CO compared to group MA. Within the whole sample the absorbance of sera from females was higher than in specimens from males ( < 0.0001). A small subset of the sera was also tested by radioimmunoprecipitation assay (RIPA). There was good agreement between the data obtained by ELISA and RIPA.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-77-8-1799
1996-08-01
2024-11-02
Loading full text...

Full text loading...

/deliver/fulltext/jgv/77/8/JV0770081799.html?itemId=/content/journal/jgv/10.1099/0022-1317-77-8-1799&mimeType=html&fmt=ahah

References

  1. Bonnez W., Da Rin C., Rose R. C., Reichman R. C. 1991; Use of human papillomavirus type II virions in an ELISA to detect specific antibodies in humans with condylomata acuminata. journal of General Virology 72:1343–1347
    [Google Scholar]
  2. Bonnez W., Kashima H. K., Leventhal B., Mounts P., Rose R. C., Reichman R. C., Shah K. V. 1992; Antibody response to human papillomavirus (HPV) type 11 in children with juvenile-onset recurrent respiratory papillomatosis (RRP). Virology 188:384–387
    [Google Scholar]
  3. Bonnez W., Da Rin C., Rose R. C., Tyring S. K., Reichman R. C. 1993; Evolution of antibody response to human papillomavirus type 11 (HPV 11) in patients with condyloma acuminatum according to treatment response. journal of Medical Virology 39:340–344
    [Google Scholar]
  4. Carter J. J., Wipf G. C., Hagensee M. E., McKnight B., Habel L. A., Lee S. K., Kuypers J., Kiviat N., Daling J. R., Koutsky L. A., Galloway D. 1995; Use of human papillomavirus type 6 capsids to detect antibodies in people with genital warts. journal of Infectious Diseases 172:11–18
    [Google Scholar]
  5. Christensen N. D., Kreider J. W., Cladel N. M., Patrick S. D., Welsh P. A. 1990; Monoclonal antibody-mediated neutralization of infectious papillomavirus type 11. journal of Virology 64:3151–3156
    [Google Scholar]
  6. Christensen N. D., Kreider J. W., Shah K. V., Rando R. F. 1992; Detection of human serum antibodies that neutralize infectious human papillomavirus type 11 virions. Journal of General Virology 73:1261–1267
    [Google Scholar]
  7. Dartmann K., Schwarz E., Gissmann L., zur Hausen H. 1986; The nucleotide sequence and genome organization of human papillomavirus type 11. Virology 151:124–130
    [Google Scholar]
  8. Gissmann L., Boshart M., Dürst M., Ikenberg H., Wagner D., zur Hausen H. 1984; Presence of human papillomavirus (HPV) DNA in genital tumors. journal of Investigative Dermatology 83: supplementum 26s–28s
    [Google Scholar]
  9. Heim K., Christensen N. D., Höpfl R., Wartusch B., Pinzger G., Zeimet A., Baumgartner P., Kreider J. W., Dapunt O. 1995; Serum IgG, IgM and IgA reactivity to human papillomavirus types 11 and 6 virus-like particles in different gynecologic patient groups. journal of Infectious Diseases 172:395–402
    [Google Scholar]
  10. Jochmus-Kudielka I., Schneider A., Braun R., Kimmig R., Koldovsky U., Schneweis K. E., Seedorf K., Gissmann L. 1989; Antibodies against the human papillomavirus type 16 early proteins in human sera: anti-E7 reactivity correlates with cervical cancer. journal of the National Cancer Institute 81:1698–1704
    [Google Scholar]
  11. Kreider J. W., Howett M. K., Wolfe S. A., Bartlett G. L., Zaino R. J., Sedlacek T. V., Mortel R. 1985; Morphological transformation in vivo of human uterine cervix with papillomavirus from condylamata acuminata. Nature 317:639–641
    [Google Scholar]
  12. Müller M., Viscidi R. P., Ulken V., Bouwes Bavinck J. N., Hill P. M., Fisher S. G., Reid R., Munoz N., Schneider A., Shah K. V., Gissmann L. 1995a; Antibodies to the E4, E6 and E7 proteins of human papillomavirus (HPV) type 16 with HPV-associated diseases and in the normal population. journal of Investigative Dermatology 104:138–141
    [Google Scholar]
  13. Müller M., Gissmann L., Christiano R. J., Sun X. Y., Frazer I. H., Jenson A. B., Alonso A., Zentgraf H., Zhou J. 1995b; Papillomavirus capsid binding and uptake by cells from different tissues and species. journal of Virology 69:948–954
    [Google Scholar]
  14. Nindl L., Benitez-Bribiesca L., Berumen J., Farmanara N., Fisher S. G., Gross G., Lopez-Carillo L., Müller M., Tomassino M., Vasquez- Curiel A., Gissmann L. 1994; Antibodies against linear and conformational epitopes of the human papillomavirus (HPV) type 16 E6 and E7 oncoproteins in sera of cervical cancer patients. Archives of Virology 137:341–353
    [Google Scholar]
  15. Rose R. C., Bonnez W., Reichman R. C., Garcea R. L. 1993; Expression of human papillomavirus type 11 L1 protein in insect cells: in vivo and in vitro assembly of virus-like particles. Journal of Virology 67:1936–1944
    [Google Scholar]
  16. Rose R. C., Reichman R. C., Bonnez W. 1994a; Human papillomavirus (HPV) type 11 recombinant virus-like particles induce the formation of neutralizing antibodies and detect HPV-specific antibodies in human sera. journal of General Virology 75:2075–2079
    [Google Scholar]
  17. Rose R. C., Bonnez W., Da Rin C., McCance D. J., Reichman R. C. 1994b; Serological differentiation of human papillomavirus types 11, 16 and 18 using recombinant virus-like particles. journal of General Virology 75:2445–2449
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-77-8-1799
Loading
/content/journal/jgv/10.1099/0022-1317-77-8-1799
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error