1887

Abstract

A macaque monkey infected with NM-3, a human immunodeficiency virus type 1 (HIV-1)-simian immunodeficiency virus strain mac (SIVmac) chimeric virus with and derived from HIV-1 and LTR, and derived from SIVmac, became a long-term carrier (more than 2.8 years). This monkey produced neutralizing antibodies to the original NM-3 as well as to the parental HIV-1. The virus recovered at 116 weeks replicated more rapidly and productively in macaque peripheral blood mononuclear cells than the original virus. The recovered virus was not neutralized either by antibodies raised early in the monkey or by a neutralizing monoclonal antibody that recognizes the V3 loop of HIV-1 Env, whereas both the early antibodies and the monoclonal antibody neutralized the original NM-3. Analysis of the virus genomic population revealed a few common mutations in the V3 region that caused amino acid changes. These data are consistent with the hypothesis that the virus escaped from the early antibodies and that the observed mutations contributed to this, as with HIV-1-infected humans. The observed mutations could equally well be the result of adaptation to simian cells. These results suggest that the HIV-1-SIVmac chimeric virus will be useful for investigating genetic variation of HIV-1 and alteration of biological properties in relation to the host immune response.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-77-8-1649
1996-08-01
2021-09-24
Loading full text...

Full text loading...

/deliver/fulltext/jgv/77/8/JV0770081649.html?itemId=/content/journal/jgv/10.1099/0022-1317-77-8-1649&mimeType=html&fmt=ahah

References

  1. Albert J., Abrahamsson B., Nagy K., Aurelius E., Gaines H., Nyström G., Fenyö E. M. 1990; Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera. AIDS 4:107–112
    [Google Scholar]
  2. Arendrup M., Nielsen C., Hansen J. -E. S., Pedersen C., Mathiesen L., Nielsen J. O. 1992; Autologous HIV-1 neutralizing antibodies: emergence of neutralization-resistant escape virus and subsequent development of escape virus neutralizing antibodies. Journal of Acquired Immune Deficiency Syndromes 5:303–307
    [Google Scholar]
  3. Burns D. W., Desrosiers R. C. 1991; Selection of genetic variants of simian immunodeficiency virus in persistently infected rhesus monkeys. Journal of Virology 65:1843–1854
    [Google Scholar]
  4. Burns D. W., Collignon C., Desrosiers R. C. 1993; Simian immunodeficiency virus mutants resistant to serum neutralization arise during persistent infection of rhesus monkeys. Journal of Virology 67:4104–4113
    [Google Scholar]
  5. Cheng-Mayer C., Seto D., Tateno M., Levy J. A. 1988; Biologic features of HIV-1 that correlate with virulence in the host. Science 240:80–82
    [Google Scholar]
  6. Clapham P. R., Weiss R. A., Dalgleish A. G., Exley M., Whitby D., Hogg N. 1987; Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: receptor modulation and differentiation induced by phorbol ester. Virology 158:44–51
    [Google Scholar]
  7. de Jong J. J., de Ronde A., Keuien W., Tersmette M., Goudsmit J. 1992a; Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution. Journal of Virology 66:6777–6780
    [Google Scholar]
  8. de Jong J. J., Goudsmit J., Keuien W., Klaver B., Krone W., Tersmette M., de Ronde A. 1992b; Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity. Journal of Virology 66:757–765
    [Google Scholar]
  9. Grimaila R. J., Fuller B. A., Rennert P. D., Nelson M. B., Hammarskjöld M. -L., Potts B., Murray M., Putney S. D., Gray G. 1992; Mutations in the principal neutralization determinant of human immunodeficiency virus type 1 affect syncytium formation, virus infectivity, growth kinetics, and neutralization. Journal of Virology 66:1875–1883
    [Google Scholar]
  10. Holmes E. C., Zhang L. Q., Simmonds P., Ludlam C. A., Brown A. J. 1992; Convergent and divergent sequence evolution in the surface envelope glycoprotein of human immunodeficiency virus type 1 within a single infected patient. Proceedings of the National Academy of Sciences, USA 89:4835–4839
    [Google Scholar]
  11. Hoxie J. A., Haggarty B. S., Bonser S. E., Rackowski J. L., Shan H., Kanki P. J. 1988; Biological characterization of a simian immunodeficiency virus-like retrovirus (HTLV-IV): evidence for CD4-associated molecules required for infection. Journal of Virology 62:2557–2568
    [Google Scholar]
  12. Ivanoff L. A., Looney D. J., McDanal C., Morris J. F., Wong-Staal F., Langlois A. J., Petteway S. R. Jr, Matthews T. J. 1991; Alteration of HIV-1 infectivity and neutralization by a single amino acid replacement in the V3 loop domain. AIDS Research and Human Retroviruses 7:595–603
    [Google Scholar]
  13. Javaherian K., Langlois A. J., Schmidt S., Kaufmann M., Cates N., Langedijk J. P., Meloen R. H., Desrosiers R. C., Burns D. P., Bolognesi D. P., Larosa G. J., Putney S. D. 1992; The principal neutralization determinant of simian immunodeficiency virus differs from that of human immunodeficiency virus type 1. Proceedings of the National Academy of Sciences, USA 89:1418–1422
    [Google Scholar]
  14. Kärber G. 1931; Beitrag zur kollektiven behandlung pharmako-logischer reihenversuche. Archiv fuer Experimented Pathologie und Pharmakologie 162:480
    [Google Scholar]
  15. Kent K. A., Rud E., Corcoran T., Powell C., Thiriart C., Collignon C., Stott E. J. 1992; Identification of two neutralizing and 8 nonneutralizing epitopes on simian immunodeficiency virus envelope using monoclonal antibodies. AIDS Research and Human Retroviruses 8:1147–1151
    [Google Scholar]
  16. Kestler H., Kodama T., Ringler D., Marthas M., Pedersen N., Lackner A., Regier D., Sehgal P., Daniel M., King N., Desrosiers R. 1990; Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. Science 248:1109–1111
    [Google Scholar]
  17. Kirchhoff F., Mori K., Desrosiers R. C. 1994; The V3′ domain is a determinant of simian immunodeficiency virus cell tropism. Journal of Virology 68:3682–3692
    [Google Scholar]
  18. Kuiken C. L., de Jong J. -J., Baan E., Keuien W., Tersmette M., Goudsmit J. 1992; Evolution of the V3 envelope domain in proviral sequences and isolates of human immunodeficiency virus type 1 during transition of the viral biological phenotype. Journal of Virology 66:4622–4627
    [Google Scholar]
  19. Li J. T., Halloran M., Lord C. I., Watson A., Ranchalis J., Fung M., Letvin N. L., Sodroski J. G. 1995; Persistent infection of macaques with simian-human immunodeficiency viruses. Journal of Virology 69:7061–7071
    [Google Scholar]
  20. Masuda T., Matsushita S., Kuroda M. J., Kannagi M., Takatsuki K., Harada S. 1990; Generation of neutralization-resistant HIV-1 in vitro due to amino acid interchanges of the third hypervariable env region. Journal of Immunology 145:3240–3246
    [Google Scholar]
  21. Matsushita S., Robert-Guroff M., Rusche J., Koito A., Hattori T., Hoshino H., Javaherian K., Takatsuki K., Putney S. 1988; Characterization of a human immunodeficiency virus neutralizing monoclonal antibody and mapping of the neutralizing epitope. Journal of Virology 62:2107–2114
    [Google Scholar]
  22. McKeating J. A., Gow J., Goudsmit J., Pearl L. H., Mulder C., Weiss R. A. 1989; Characterization of HIV-1 neutralization escape mutants. AIDS 3:777–784
    [Google Scholar]
  23. Miura T., Sakuragi J. -I., Kawamura M., Fukasawa M., Moriyama E. N., Gojobori T., Ishikawa K. -I., Mingle J. A. A., Netty V. B. A., Akari H., Enani M., Tsujimoto H., Hayami M. 1990; Establishment of a phylogenetic survey system for AIDS related lentiviruses and demonstration of a new HIV-2 subgroup. AIDS 4:1257–1261
    [Google Scholar]
  24. Ohta Y., Masuda T., Tsujimoto H., Ishikawa K., Kodama T., Morikawa S., Nakai M., Honjo S., Hayami M. 1988; Isolation of simian immunodeficiency virus from African green monkeys and seroepidemiologic survey of the virus in various non-human primates. International Journal of Cancer 41:115–122
    [Google Scholar]
  25. Oka S., Ida S., Shioda S., Takebe Y., Kobayashi N., Shibuya Y., Ohyama K., Momota K., Kimura S., Shimada K. 1994; Genetic analysis of HIV-1 during rapid progression to AIDS in an apparently healthy man. AIDS Research and Human Retroviruses 10:271–277
    [Google Scholar]
  26. Reitz M. S., Wilson C., Naugle C., Gallo R. C., Robert-Guroff M. 1988; Generation of a neutralization-resistant variant of HIV-1 is due to selection for a point mutation in the envelope gene. Cell 54:57–63
    [Google Scholar]
  27. Robert-Guroff M., Aldrich K., Muldoon R., Stern T. L., Bansal G. P., Matthews T. J., Markham P. D., Gallo R. C., Franchini G. 1992; Cross-neutralization of human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus isolates. Journal of Virology 66:3602–3608
    [Google Scholar]
  28. Rudensey L. M., Kimata J. T., Benveniste R. E., Overbaugh J. 1995; Progression to AIDS in macaques is associated with changes in the replication, tropism, and cytopathic properties of the simian immunodeficiency virus variant population. Virology 207:528–542
    [Google Scholar]
  29. Sakuragi S., Shibata R., Mukai R., Komatsu T., Fukasawa M., Sakai H., Sakuragi J.-l., Kawamura M., Ibuki K., Hayami M., Adachi A. 1992; Infection of macaque monkeys with a chimeric human and simian immunodeficiency virus. Journal of General Virology 73:2983–2987
    [Google Scholar]
  30. Shibata R., Kawamura M., Sakai H., Hayami M., Ishimoto A., Adachi A. 1991; Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells. Journal of Virology 65:3514–3520
    [Google Scholar]
  31. Tremblay M., Wainberg M. A. 1990; Neutralization of multiple HIV-1 isolates from a single subject by autologous sequential sera. Journal of Infectious Diseases 162:735–737
    [Google Scholar]
  32. Willy R. L., Smith D. H., Laskey L. A., Theodore T. S., Early P. L., Moss B., Capon D. J., Martin M. A. 1988; In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity. Journal of Virology 62:139–147
    [Google Scholar]
  33. Wolfs T. W., Zwart G., Bakker M., Valk M., Kuiken C. L., Goudsmit J. 1991; Naturally occurring mutations within HIV-1 V3 genomic RNA lead to antigenic variation dependent on a single amino acid substitution. Virology 185:195–205
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-77-8-1649
Loading
/content/journal/jgv/10.1099/0022-1317-77-8-1649
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error