1887

Abstract

Pathogenic serotype 1 strains of infectious bursal disease virus (IBDV) replicate efficiently in lymphoid cells of the bursa of Fabricius of chicken. Lymphoid cells in other organs are not susceptible. Apathogenic serotype 2 strains do not replicate in lymphoid bursa cells or in other lymphoid cells. Chicken embryo fibroblasts (CEF), however, efficiently replicate strains of either serotype. Binding studies showed that strains of both IBDV serotypes bind to lymphoid cells isolated from the bursa, thymus or spleen, indicating that restriction of IBDV replication to lymphoid B cells is not determined by the presence of specific receptor sites. The specificity of binding was demonstrated by saturation and competition experiments. These revealed the presence of different receptors: CEF had receptors common to both serotypes and specific ones for each serotype. Receptor sites common to both serotypes were also present on lymphoid cells; however, additional serotype-specific sites were only demonstrated for the apathogenic serotype 2 strain. Strains of both serotypes specificially bound to proteins with molecular masses of 40 kDa and 46 kDa, exposed on the surface of CEF and lymphoid cells. Competition experiments indicated that these proteins might represent the common receptor sites of IBDV.

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1996-06-01
2024-12-06
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References

  1. Ambler L., McKay M. 1991; Reovirus 1 and 3 bind and internalize at the apical surface of intestinal epithelial cells. Virology 184:162–169
    [Google Scholar]
  2. Bass D. M., Mackow E. R., Greenberg H. B. 1991; Identification and partial characterization of a rhesus rotavirus binding glycoprotein on murine enterocytes. Virology 183:602–610
    [Google Scholar]
  3. Becht H. 1980; Infectious bursal disease virus. Current Topics in Microbiology and Immunology 90:107–121
    [Google Scholar]
  4. Becht H., Müller H., Müller H. K. 1988; Comparative studies on structural and antigenic properties of two serotypes of infectious bursal disease virus. Journal of General Virology 69:631–640
    [Google Scholar]
  5. Beug H., MÜller H., Grieser S., Doederlein G., Graf T. 1981; Hematopoetic cells transformed in vitro by REVT avian reticuloendotheliosis virus express characteristics of very immature lymphoid cells. Virology 11:295–309
    [Google Scholar]
  6. Borrow P., Oldstone M. B. A. 1992; Characterization of lymphocytic choriomeningitis virus–binding protein(s): a candidate cellular receptor for the virus. Journal of Virology 66:7270–7281
    [Google Scholar]
  7. Boyle J. F., Weismiller D. G., Holmes K. V. 1987; Genetic resistance to mouse hepatitis virus correlates with absence of virusbinding activity on target tissue. Journal of Virology 61:185–189
    [Google Scholar]
  8. Burkhardt E., Müller H. 1987; Susceptibility of chicken blood lymphoblasts and monocytes to infectious bursal disease virus. Archives of Virology 94:297–303
    [Google Scholar]
  9. Chettle N. J., Eddy R. K., Wyeth P. J. 1985; The isolation of infectious bursal disease virus from turkeys in England. British Veterinary Journal 141:141–145
    [Google Scholar]
  10. Choi A. H. C., Paul R. W. P., Lee P. W. K. 1990; Reovirus binds to multiple plasma membrane proteins of mouse L fibroblasts. Virology 178:316–320
    [Google Scholar]
  11. Coligan J. E., Kruisbeek A. M., Margulies D. H., Shevach E. M., Strober W. (editors) 1992; Solubilization of lymphocytes. In Current Protocols in Immunology pp 8.1.1–8.1.2. New York: John Wiley & Sons;
    [Google Scholar]
  12. Crane S. E., Buzy J., Clements J. E. 1991; Identification of cell membrane proteins that bind visna virus. Journal of Virology 65:6137–6143
    [Google Scholar]
  13. Cursiefen D. 1980; Wirtszellspezifitat des Virus der infektidsen Bursitis. Fortschritte der Veterinarmedizin 30:194–196
    [Google Scholar]
  14. Cursiefen D., KÄufer I., Becht H. 1979; Loss of virulence in a small plaque mutant of the infectious bursal disease virus. Archives of Virology 59:39–46
    [Google Scholar]
  15. Dalziel R. G., Hopkins J., Watt N. J., Dutia B. M., Clarke H. A. K., McConnell I. 1991; Identification of a putative cellular receptor for the lentivirus visna virus. Journal of General Virology 72:1905–1911
    [Google Scholar]
  16. El-Ghorr A. A., Gordon D. A., George K., Marator-Flier E. 1992; Regulation of expression of the reovirus receptor on differentiated HL60 cells. Journal of General Virology 73:1961–1968
    [Google Scholar]
  17. Fotiadis C., Kilpatrick D. R., Lipton H. L. 1991; Comparison of the binding characteristics to BHK-21 cells of viruses representing the two Theiler’s virus neurovirulence groups. Virology 182:365–370
    [Google Scholar]
  18. Gavalchin J., Fan N., Lane M. J., Papsidero L., Poisz B. J. 1993; Identification of a putative cellular receptor for HTLV-1 by a monoclonal antibody, MAb 34-23. Virology 194:1–9
    [Google Scholar]
  19. Haywood A. M. 1994; Virus receptors: binding, adhesion strengthening, and changes in viral structure. Journal of Virology 68:1–5
    [Google Scholar]
  20. Hudson L., Pattison M., Thantrey N. 1975; Specific B lymphocyte suppression by infectious bursal agent (Gumboro disease virus) in chickens. European Journal of Immunology 5:675–679
    [Google Scholar]
  21. Ismail N. M., Saif Y. M., Moorhead P. D. 1988; Lack of pathogenicity of five serotype 2 infectious bursal disease viruses. Avian Disease 32:757–759
    [Google Scholar]
  22. Jackwood D. J., Saif Y. M., Hughes J. H. 1982; Characteristics and serologic studies of two serotypes of infectious bursal disease virus in turkeys. Avian Disease 26:871–882
    [Google Scholar]
  23. Jackwood D. J., Saif Y. M., Moorhead P. D., Bishop G. 1984; Failure of two serotype II infectious bursal disease viruses to affect the humoral immune response of turkeys. Avian Disease 28:100–116
    [Google Scholar]
  24. Jackwood D. J., Saif Y. M., Moorhead P. D. 1985; Immunogenicity and antigenicity of infectious bursal disease virus serotypes 1 and 2 in chickens. Avian Disease 29:1184–1194
    [Google Scholar]
  25. Käufer I., Weiss E. 1980; Significance of bursa of Fabricius as target organ in infectious bursal disease of chickens. Infection and Immunity 27:364–367
    [Google Scholar]
  26. Kibenge F. S. B., Dhillon A. S., Russell R. G. 1988; Biochemistry and immunology of infectious bursal disease virus. Journal of General Virology 69:1757–1775
    [Google Scholar]
  27. Kilpatrick D. R., Lipton H. 1991; Predominant binding of Theiler’s viruses to a 34-kilodalton receptor protein on susceptible cell lines. Journal of Virology 65:5244–5249
    [Google Scholar]
  28. Lange H., Müller H., Käufer I., Becht H. 1987; Pathogenic and structural properties of wild type infectious bursal disease virus (IBDV) and virus grown in vitro. Archives of Virology 92:187–196
    [Google Scholar]
  29. McNulty M. S., Allan G. M., McFerran J. B. 1979; Isolation of infectious bursal disease from turkeys. Avian Pathology 8:205–212
    [Google Scholar]
  30. Maeda T., Balakrishnan K., Mehdi S. Q. 1983; A simple and rapid method for the preparation of plasma membranes. Biochimica et Biophysica Acta 731:115–120
    [Google Scholar]
  31. Marriott S. J., Griffith G. R., Consigli R. A. 1987; Octy1-β-glucopyranoside extracts polyomavirus receptor moieties from the surface of mouse kidney cells. Journal of Virology 61:375–382
    [Google Scholar]
  32. Mehdi H., Kaplan M. J., Anlar F. Y., Yang X., Bayer R., Sutherland K., Peeples M. E. 1994; Hepatitis B virus surface antigen binds to apolipoprotein H. Journal of Virology 68:2415–2424
    [Google Scholar]
  33. Meier T., Arni S., Malarkannan S., Poincelet M., Hoessli D. 1992; Immunodetection of biotinylated lymphocyte-surface proteins by enhanced chemiluminescence: a nonradioactive method for cell-surface protein analysis. Analytical Biochemistry 204:220–226
    [Google Scholar]
  34. Mischak H., Neubauer C., Berger B., Kuechler E., Blaas D. 1988; Detection of the human rhinovirus minor group receptor on renaturing Western blots. Journal of General Virology 69:2653–2656
    [Google Scholar]
  35. Müller H. 1986; Replication of infectious bursal disease virus in lymphoid cells. Archives of Virology 87:191–203
    [Google Scholar]
  36. Müller H., Becht H. 1982; Biosynthesis of virus-specific proteins in cells infected with infectious bursal disease virus and their significance as structural elements for infectious virus and incomplete particles. Journal of Virology 44:384–392
    [Google Scholar]
  37. Müller H., Lange H., Becht H. 1986; Formation, characterization and interfering capacity of a small plaque mutant and of incomplete virus particles of the infectious bursal disease virus. Virus Research 4:297–304
    [Google Scholar]
  38. Nick H., Cursiefen D., Becht H. 1976; Structural and growth characteristics of infectious bursal disease virus. Journal of Virologv 18:227–234
    [Google Scholar]
  39. Verdin E. M., King G. L., Maratos-Flier E. 1989; Characterization of a common high-affinity receptor for reovirus serotypes 1 and 3 on endothelial cells. Journal of Virology 63:1318–1325
    [Google Scholar]
  40. Winterfield R. W., Fadly A. M., Bickford A. 1972; Infectivity and distribution of infectious bursal disease virus in the chicken. Persistence of the virus and lesions. Avian Disease 16:622–632
    [Google Scholar]
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