1887

Abstract

Perinatal transmission of human papillomavirus type 16 (HPV-16) and persistence of virus DNA in infants until 6 months of age has been described. To confirm the origin of infant infections as maternal, we determined the nucleotide sequence of the upstream regulatory region (URR; bp 7540 to 157) of HPV-16 in samples from 13 HPV-16 DNA-positive mothers and their infants at 6 weeks and 2 years of age. Identical HPV-16 variant URR sequences were found in two mother/infant samples and similar variants were found in three sets. Four mothers with samples which contained prototypic HPV-16 sequences delivered infants who also had the prototypic sequence. Four mothers with variant URRs delivered infants who harboured either prototypic or different URR variants. Thus, concordant variants or prototypic sequences were detected in nine of 13 mother/infant samples, indicating that up to 69.2% of HPV-16-positive infants acquire virus from their mothers.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-77-6-1139
1996-06-01
2022-09-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/77/6/JV0770061139.html?itemId=/content/journal/jgv/10.1099/0022-1317-77-6-1139&mimeType=html&fmt=ahah

References

  1. Cason J., Kaye J. N., Jewers R. J., Kambo P. K., Bible J. M., Kell B., Shergill B., Pakarian F., Raju K. S., Best J. M. 1995; Perinatal infection and persistence of human papillomavirus types 16 and 18 in infants. Journal of Medical Virology 47:209–218
    [Google Scholar]
  2. Cavuslu S., Starkey W. G., Kaye J. N., Biswas C., Mant C., Kell B., Rice P., Best J. M., Cason J. 1996; Detection of human papillomavirus type-16 (HPV-16) DNA utilising microtitreplate based amplification reactions and a solid-phase enzymeimmunoassay detection system. Journal of Virological Methods (in press)
    [Google Scholar]
  3. Fredericks B. D., Balkin A., Daniel H. W., Schonrock J., Ward B., Frazer I. H. 1993; Transmission of human papillomavirus from mother to child. Australian and New Zealand Journal of Obstetrics and Gynaecology 33:30–32
    [Google Scholar]
  4. Ho L., Shan S. Y., Chow V., Chong T., Tay S.-K., Villa L. L., Bernard H.-U. 1991; Sequence variations of human papillomavirus type 16 in clinical samples permit verification and extension of epidemological studies and construction of a phylogenetic tree. Journal of Clinical Microbiology 29:1765–1772
    [Google Scholar]
  5. Ho L., Tay S.-K., Chan S.-Y., Bernard H.-U. 1993; Sequence variants of human papillomavirus type 16 from couples suggest sexual transmission with low infectivity and polyclonality in genital neoplasia. Journal of Infectious Diseases 168:803–809
    [Google Scholar]
  6. Jenison S. A., Yu X., Valentine J. M., Koutsky L. A., Christiansen A. E., Beckmann A. M., Galloway D. A. 1990; Evidence of prevalent genital type human papillomavirus infections in adults and children. Journal of Infectious Diseases 162:60–69
    [Google Scholar]
  7. Jochmus-Kudielka I., Schneider A., Braun R., Kimmig R., Koldovsky U., Schneweis K. E., Seedorf K., Gissmann L. 1989; Antibodies against human papillomavirus type 16 early proteins in human sera: correlation of anti-E7 reactivity with cervical cancer. Journal of the National Cancer Institute 81:1698–1704
    [Google Scholar]
  8. Kaye J. N., Cason J., Pakarian F. B., Jewers R. J., Kell B., Bible J. M., Raju K. S., Best J. M. 1994; Viral load as a determinant for transmission of human papillomavirus type 16 from mother to child. Journal of Medical Virology 44:415–121
    [Google Scholar]
  9. Kunitakb T., Kitamura T., Guo J., Taguchi F., Kawabe K., Yogo K. 1995; Parent-to-child transmission is relatively common in the spread of human polyomavirus JC virus. Journal of Clinical Microbiology 33:1448–1451
    [Google Scholar]
  10. Lorincz A. T., Reid R., Jenson B., Greenberg M. D., Lancaster W., Kurman R. J. 1992; Human papillomavirus infection of the cervix: relative risk association of 15 common anogenital types. Obstetrics and Gynecology 79:328–337
    [Google Scholar]
  11. May M., Dong X.-P., Beyer-Finkler E., Strubenrauch F., Fuchs P. G., Pfister H. 1994; The E6/E7 promoter of extrachromosomal HPV-16 DNA in cervical carcinomas escapes from cellular repression by mutation of target sequences for YY1. EMBO Journal 13:1460–1466
    [Google Scholar]
  12. Munoz N., Bosch F. X. 1989; Epidemiology of cervical cancer. In Human Papillomavirus and Cervical Cancer pp. 9–39 Edited by Munoz B., Bosch F. X., Jensen O. M. Lyon: International Agency for Research on Cancer;
    [Google Scholar]
  13. Rock B., Naghasfar Z., Barnett Z. 1986; Genital tract papillomavirus infections in children. Archives of Dermatology 122:1129–1132
    [Google Scholar]
  14. Roman A., Fife K. 1986; Human papillomavirus DNA associated with foreskins of normal newborns. Journal of Infectious Diseases 153:855–860
    [Google Scholar]
  15. Saiki R. A., Bugawan T. L., Horn G. T., Mullis K. B., Erlich H. A. 1986; Analysis of enzymatically amplified β;-globin and HLA DQ alpha DNA with allele specific oligonucleotide probes. Nature 324:163–166
    [Google Scholar]
  16. Sedlaceck T. V., Lindheim S., Eder C., Hasty L., Woodland M., Ludomirsky A., Rando R. F. 1989; Mechanism for human papillomavirus transmission at birth. American Journal of Obstetrics and Gynecology 161:55–59
    [Google Scholar]
  17. Seedorf K., Krammer G., Durst M., Suhai S., Rowenkamp W. G. 1985; Human papillomavirus type 16 DNA sequence. Virology 145:181–185
    [Google Scholar]
  18. Simon M., Khan T., Schneider A., Pirsig W. 1994; Laryngeal carcinoma in a 12 year old child: association with human papillomavirus types 18 and 33. Archives of Otolaryngology, Head & Neck Surgery 120:277–282
    [Google Scholar]
  19. Xi F. X., Demers W., Kiviat N. B., Kuypers J., Beckmann A. M., Galloway D. A. 1993; Sequence variation in the non-coding region of human papillomavirus type 16 detected by single stranded conformation polymorphism analysis. Journal of Infectious Diseases 168:610–617
    [Google Scholar]
  20. Xi F. X., Demers W., Koutsy L. A., Kiviat N. B., Kuypers J., Watts D. H., Holmes K. K., Galloway D. A. 1995; Analysis of human papillomavirus type 16 variants indicates establishment of persistent infection. Journal of Infectious Diseases 172:747–755
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-77-6-1139
Loading
/content/journal/jgv/10.1099/0022-1317-77-6-1139
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error