1887

Abstract

We isolated a divergent simian T-lymphotropic virus (STLV) (strain PP1664) from a wild-caught African bonobo (pygmy chimpanzee, ). Molecular and phylogenetic characterization of this virus show that it reliably separates from the two well-established primate T-lymphotropic virus types, HTLV-I/STLV-I (PTLV-I) and PTLV-II, and from a third type isolated from an African-born and designated by us as PTLV-L. Four of eight bonobos kept at the Antwerp Zoo, Belgium, showed an aberrant PTLV serology. We amplified and sequenced a 709 bp PTLV proviral fragment from one of the reactive bonobos. It differs by about 25% from the homologous nucleotide sequences of PTLV-I and PTLV-L and by about 17% from PTLV-II. This is comparable to the differences among the three known types. Including the most divergent STLV-I strains sequenced to date, for example, strain PHSu1 sequenced here, the divergence in this region within PTLV-I is less than 11% and within PTLV-II less than 4%. Although very divergent, this new bonobo STLV is the closest well-characterized simian relative of HTLV-II, raising the possibility of very divergent new HTLV strains. Our results show that the number of PTLV types should be considered open and that the variety of indigenous viruses in the PTLV group is greatest in Africa. Thus, as for the other primate retroviruses HIV and SIV, PTLV most probably has its origins in Africa.

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1996-05-01
2022-05-25
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References

  1. Bastian I., Gardner J., Webb D., Gardner I. 1992; Isolation of a human T-lymphotropic virus type I strain from Australian Aboriginals. Journal of Virology 67:843–851
    [Google Scholar]
  2. Chen Y.-M. A., Jang Y.-J., Kanki P. J., Yu Q.-C., Wang J.-J., Montali R. J., Samuel K. P., Papas T. S. 1994; Isolation and characterization of simian T-cell leukemia virus type II from New World monkeys. Journal of Virology 68:1149–1157
    [Google Scholar]
  3. Dube D. K., Sherman M. P., Saksena N. K., Bryz-Gornia V., Mendelson J., Love J., Arnold C. B., Spicer T., Dube S., Glaser J. B., Williams A. E., Nishimura M., Jacobsen S., Ferrer J. F., Del Pino N., Quiruelas S., Poiesz B. J. 1993; Genetic heterogeneity in human T-cell leukemia/lymphoma virus type II. Journal of Virology 67:1175–1184
    [Google Scholar]
  4. Evangelista A., Maroushek S., Minnigan H., Larson A., Retzel E., Haase A., Gonzalez-Dunia D., McFarlin D., Mingioli E., Jacboson S., Osame M., Sonoda S. 1980; Nucleotide sequence analysis of a provirus derived from an individual with tropical spastic paraparesis. Microbial Pathogenesis 8:259–278
    [Google Scholar]
  5. Felsenstein J. 1985; Confidence limits on phylogenies: an approach using the bootstrap. Evolution 39:783–791
    [Google Scholar]
  6. Felsenstein J. 1989; PHYLIP – Phylogeny inference package (version 3.2). Cladistics 5:164–166
    [Google Scholar]
  7. Ferrer J. F., Del Pino N., Esteban E., Sherman M. P., Dube S., Dube D. K., Basombrio M. A., Pimentel E., Segovia A., Quirulas S., Poiesz B. J. 1993; High rate of infection with the human T-cell leukemia retrovirus type II in four Indian populations of Argentina. Virology 197:576–584
    [Google Scholar]
  8. Froment A., Delaporte E., Dazza M.-C., Larouze B. 1993; HTLV-II among Pygmies from Cameroon (Letter). AIDS Research and Human Retroviruses 9:707
    [Google Scholar]
  9. Gallo D., Penning L. M., Hanson C. V. 1991; Detection and differentiation of antibodies to human T-cell lymphotropic virus types I and II by the immunofluorescence method. Journal of Clinical Microbiology 29:2345–2347
    [Google Scholar]
  10. Gessain A., Gallo R. C., Franchini G. 1992; Low degree of human T-cell leukemia/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations. Journal of Virology 66:2288–2295
    [Google Scholar]
  11. Gessain A., Boeri E., Yanagihara R., Gallo R. C., Franchini G. 1993; Complete nucleotide sequence of a highly divergent human T-cell leukemia (lymphotropic) virus type I (HTLV-I) variant from Melanesia: genetic and phylogenetic relationship to HTLV-I strains from other geographical regions. Journal of Virology 67:1015–1023
    [Google Scholar]
  12. Gessain A., Tuppin P., Kazanji M., Cosnefroy J.-Y., Georges-Courbot M.-C., Jean Georges A., de The G. 1994; A distinct molecular variant of HTLV-IIB in Gabon, Central Africa. AIDS Research and Human Retroviruses 10:753–755
    [Google Scholar]
  13. Gessain A., Mauclere P., Froment A., Biglione M., Le Hesran J. Y., Tekaia Fr., Millan J., de The G. 1995; Isolation and molecular characterization of a human T-cell lymphotropic virus type II (HTLV-II), subtype B, from a healthy Pygmy living in a remote area of Cameroon: an ancient origin for HTLV-II in Africa. Proceedings of the National Academy of Sciences, USA 92:4041–4045
    [Google Scholar]
  14. Giri A., Markham P., Digilio L., Hurteau G., Gallo R. C., Franchini G. 1994; Isolation of a novel simian T-cell lymphotropic virus form Pan paniscus that is distantly related to the human T-cell leukemia/lymphotropic virus types I and II. Journal of Virology 68:8392–8395
    [Google Scholar]
  15. Goubau P., Desmyter J., Ghesquiere J. 1992; HTLV-II among pygmies (Letter). Nature 359:201
    [Google Scholar]
  16. Goubau P., Liu H.-F., de Lange G. G., Vandamme A.-M., Desmyter J. 1993; HTLV-II seroprevalence in Pygmies across Africa since 1970. AIDS Research and Human Retroviruses 9:709–713
    [Google Scholar]
  17. Goubau P., Van Brussel M., Vandamme A.-M., Liu H.-F., Desmyter J. 1994; A primate T-lymphotropic virus, PTLV-L, different from human T-lymphotropic viruses types I and II, in a wild-caught baboon (Papio hamadryas). Proceedings of the National Academy of Sciences, USA 91:2848–2852
    [Google Scholar]
  18. Goubau P., Vandamme A.-M., Beuselinck K., Desmyter J. 1996; Proviral HTLV-I and HTLV-II in the Efe pygmies of N. E. Zaire. Journal of AIDS and Human Retrovirology (in press)
    [Google Scholar]
  19. Hall W. W., Takahashi H., Liu C., Kaplan M. H., Scheewind O., Ijichi S., Nagashima K., Gallo R. C. 1992; Multiple isolates and characteristics of human T-cell leukemia virus type II. Journal of Virology 66:2456–2463
    [Google Scholar]
  20. Hashimoto K., Lalkaka J., Fujisawa J.-L., Singhal B. S., Machigashira K., Kubota R., Suehara M., Osame M., Yoshida M. 1993; Limited sequence divergence of HTLV-I of Indian HAM/TSP patients from a prototype Japanese isolate. AIDS Research and Human Retroviruses 9:495–498
    [Google Scholar]
  21. Hjelle B., Chaney R. 1992; Sequence variation of functional HTLV-II tax alleles among isolates from an endemic population: lack of evidence for oncogenic determinant in tax . Journal of Medical Virology 36:136–141
    [Google Scholar]
  22. Igarishi T., Yamashita M., Miura T., Osei-Kwasi M., Aysi N. K., Shiraki H., Kurimura T., Hayami M. 1993; Isolation and genomic analysis of human T lymphotropic virus type II from Ghana. AIDS Research and Human Retroviruses 9:1039–1042
    [Google Scholar]
  23. Ishak R., Harrington W. J. Jr, Azevedo V. N., Eiraku N., Ishak M. O. G., Guerreiro J. F., Santos S. B., Kubo T., Monken C., Alexander S., Hall W. W. 1995; Identification of human T cell lymphotropic virus type Ila infection in the Kayapo, an indigenous population of Brazil. AIDS Research and Human Retroviruses 11:813–821
    [Google Scholar]
  24. Kira J. K., Koyanagi Y., Yamada T., Itoyama Y., Tateishi J., Akizuki S., Kishikawa M., Baba E., Nakamura M., Suzuki J., Nakamura T., Nakamura N., Yamamoto N., Goto I. 1994; Sequence heterogeneity of HTLV-I proviral DNA in the central nervous system of patients with HTLV-I-associated myelopathy. Annals of Neurology 36:149–156
    [Google Scholar]
  25. Komurian F., Pelloquin F., de The G. 1991; In vivo genomic variability of human T-cell leukemia virus type I depends more upon geography than upon pathologies. Journal of Virology 65:3770–3778
    [Google Scholar]
  26. Koralnik I. J., Boeri E., Saxinger W. C., Lo Monico A., Fullen J., Gessain A., Guo H.-G., Gallo R. C., Markham P., Kalyanaraman V., Hirsch V., Allan J., Murthy K., Alford P., Slattery J. P., O’Brien S. J., Franchini G. 1994; Phylogenetic associations of human and simian T-cell leukemia/ lymphotropic virus type I strains: evidence for interspecies transmission. Journal of Virology 68:2693–2707
    [Google Scholar]
  27. Kwok S., Jellogg D., Ehrlich G., Poiesz B., Bhagavati S., Sninsky J. J. 1988; Characterization of a sequence of human T cell leukemia virus type I from a patient with chronic progressive myelopathy. Journal of Infectious Diseases 158:1193–1197
    [Google Scholar]
  28. Lairmore M. D., Jacobson S., Gracia F., De B. K., Castillo L., Larreategui L., Roberts B. D., Levine P. H., Blattner W. A., Kaplan J. E. 1990; Isolation of human T-cell lymphotropic virus type 2 from Guaymi Indians in Panama. Proceedings of the National Academy of Sciences, USA 87:8840–8844
    [Google Scholar]
  29. Lee H., Idler K. B., Swanson P., Aparicio J. J., Chin K. K., Lax J. P., Nguyen M., Mann T., Leckie G., Zanetti A., Marinucci G., Chen I. S. Y., Rosenblatt J. D. 1993; Complete nucleotide sequence of HTLV-II isolate RNA: comparison of envelope sequence variation of HTLV-II isolates from U.S. blood donors and U.S. and Italian IV drug users. Virology 196:57–69
    [Google Scholar]
  30. Liu H.-F., Vandamme A.-M., Kazadi K., Carton H., Desmyter J., Goubau P. 1994a; Familial transmission and minimal sequence variability of human T-lymphotropic virus type I (HTLV-I) in Zaire. AIDS Research and Human Retroviruses 10:1135–1142
    [Google Scholar]
  31. Liu H.-F., Vandamme A.-M., Van Brussel M., Desmyter J., Goubau P. 1994b; New retroviruses in human and simian T-lymphotropic viruses (Letter). Lancet 344:265–266
    [Google Scholar]
  32. Loftus R. T., MacHugh D. E., Bradley D. G., Sharp P. M., Cunningham P. 1994; Evidence for two independent domestications of cattle. Proceedings of the National Academy of Sciences, USA 91:2757–2761
    [Google Scholar]
  33. Louwagie J., McCutchan F. E., Pesters M., Brennan T. P., Sanders-Buell E., Eddy G. A., van der Groen G., Fransen K., Gershy-Damet G.-M., Deleys R., Burke D. S. 1993; Phylogenetic analysis of gag genes from 70 international HIV-1 isolates provides evidence for multiple genotypes. AIDS 7:769–780
    [Google Scholar]
  34. Major M. E., Nightingale S., Desselberger U. 1993; Complete sequence conservation of the human T cell leukaemia virus type 1 tax gene within a family cluster showing different pathologies. Journal of General Virology 74:2531–2537
    [Google Scholar]
  35. Malik K. T. A., Even J., Karp as A. 1988; Molecular cloning and complete nucleotide sequence of an adult T cell leukaemia virus/ human T cell leukaemia virus type I (ATLV/HTLV-I) isolate of Carribean origin: relationship to other members of the ATLV/HTLV-I subgroup. Journal of General Virology 69:1695–1710
    [Google Scholar]
  36. Maloney E. M., Biggar R. J., Neel J. V., Taylor M. E., Hahn B. H., Shaw G. M., Blattner W. A. 1992; Endemic human T cell lymphotropic virus type II infection among isolated Brazilian Amerindians. Journal of Infectious Diseases 166:100–107
    [Google Scholar]
  37. Myers G., Korber B., Wain-Hobson S., Smith R. F., Pavlakis G. N. 1994 Human Retrovirus and AIDS, I-H. A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences Theoretical Biology and Biophysics Group Los Alamos National Laboratory; Los Alamos, N. Mex., USA:
    [Google Scholar]
  38. Neel J. V., Biggar R. J., Sukernik R. I. 1994; Virologic and genetic studies relate Amerind origins to the indigenous people of the Mongolia/Manchuria/southeastern Siberia region. Proceedings of the National Academy of Sciences, USA 91:10737–10741
    [Google Scholar]
  39. Paine E., Garcia J., Philpott T. C., Shaw G., Ratner L. 1991; Limited sequence variation in human T-lymphotropic virus type I isolates from North American and African patients. Virology 182:111–123
    [Google Scholar]
  40. Pardi D., Switzer W. M., Hadlock K. G., Kaplan J. E., Lal R. B., Folks T. M. 1993; Complete nucleotide sequence of an Amerindian human T-cell lymphotropic virus type II (HTLV-II) isolate: identification of a variant HTLV-II subtype b from a Guaymi Indian. Journal of Virology 67:4659–4664
    [Google Scholar]
  41. Sagata N., Yasunaga T., Tsuzuku-Kawamura J., Ohishi K., Ogawa Y., Ikawa Y. 1985; Complete nucleotide sequence of the genome of bovine leukemia virus: its evolutionary relationship to other retroviruses. Proceedings of the National Academy of Sciences, USA 82:677–681
    [Google Scholar]
  42. Saksena N. K., Herve V., Durand J. P., Leguenno B., Diop O. M., Digoutte J. P., Mathiot C., Muller M. C., Love J. L., Dube S., Sherman M. P., Benz P. M., Erensoy S., Galat-Luong A., Galat G., Paul B., Dube D. K., Barre-Sinoussi F., Poiesz B. J. 1994; Seroepidemiologic, molecular, and phylogenetic analyses of simian T-cell leukemia viruses (STLV-I) from various naturally infected monkey species from Central and Western Africa. Virology 198:297–310
    [Google Scholar]
  43. Seiki M., Hattori S., Hirayama Y., Yoshida M. 1983; Human adult T-cell leukemia virus: completed nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proceedings of the National Academy of Sciences, USA 80:3618–3622
    [Google Scholar]
  44. Sharp P. M., Robertson D. L., Gao F., Hahn B. H. 1994; Origins and diversity of human immunodificiency viruses. AIDS 8: suppl 1S27–S42
    [Google Scholar]
  45. Shimotohno K., Takahashi Y., Shimizu N., Gojobori T., Golde D. W., Chen S. Y., Miwa M., Sugimura T. 1985; Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene. Proceedings of the National Academy of Sciences, USA 82:3101–3105
    [Google Scholar]
  46. Song K.-J., Nerurkar V. R., Saitou N., Lazo A., Blakeslee J. R., Miyoshi I., Yanagihara R. 1994; Genetic analysis and molecular phylogeny of simian T-cell lymphotropic virus type I: evidence for independent virus evolution in Asia and Africa. Virology 199:56–66
    [Google Scholar]
  47. Takeuchi K., Kobayashi N., Nam S. H., Yamamoto N., Hatanaka M. 1985; Molecular cloning of cDNA encoding gp68 of adult T-cell leukaemia-associated antigen: evidence for expression of the pX IV region of human T-cell leukaemia virus. Journal of General Virology 66:1825–1829
    [Google Scholar]
  48. Van Brussel M., Goubau P., Rousseau R., Desmyter J., Vandamme A.-M. 1996; The genomic structure of a new simian T-lymphotropic virus, STLV-PH969, differs from that of human T-lymphotropic viruses type I and II. Journal of General Virology 76:347–358
    [Google Scholar]
  49. Vandamme A.-M., Liu H.-F., Goubau P., Desmyter J. 1994; Primate T-lymphotropic virus type ILTR sequence variation and its phylogenetic analysis: compatibility with an African origin of PTLV-I. Virology 202:212–223
    [Google Scholar]
  50. Watanabe T., Seiki M., Hirayama Y., Yoshida M. 1986; Human T-cell leukemia virus type I is a member of the African subtype of simian viruses (STLV). Virology 148:385–388
    [Google Scholar]
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