1887

Abstract

Maedi-visna virus (MVV)-specific cytotoxic T lymphocytes (CTL) were detected, after culture with MVV antigen and recombinant human interleukin-2, in the efferent lymph and peripheral blood of sheep chronically infected with MVV. Cytotoxicity was mediated by CD8 lymphocytes and was specific for particular strains of MVV. These precursor CTL were detected in the blood between day 23 and day 100 after infection via the skin. In one out of seven persistently infected sheep MVV-specific cytotoxicity was seen in uncultured peripheral blood cells. Again the effector population consisted of CD8 lymphocytes. The only other viral infections in which CTL have been detected in peripheral blood mononuclear cells prior to secondary stimulation are those caused by the simian and human immunodeficiency viruses.

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1994-07-01
2024-12-05
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References

  1. Anderson A. A., Harkiss G. D., Watt N. J. 1994; Quantitative analysis of immunohistological changes in the synovial membrane of sheep infected with maedi-visna virus. Clinical Immunology and Immunopathology in press
    [Google Scholar]
  2. Bird P., Blacklaws B., Reyburn H. T., Allen D., Hopkins J., Sargan D., Mcconnell I. 1993; Early events in immune evasion by the lentivirus maedi-visna occurring within infected lymphoid tissue. Journal of Virology 67:5187–5197
    [Google Scholar]
  3. Blacklaws B. A., Krishna S., Minson A. C., Nash A. A. 1990; Immunogenicity of herpes simplex virus type 1 glycoproteins expressed in vaccinia virus recombinants. Virology 177:727–736
    [Google Scholar]
  4. Blacklaws B. A., Bird P., Mcconnell I. 1994; Pathogenesis and immunity in lentivirus infections of small ruminants. In Cell-Mediated Immunity in Ruminants pp. 199–212 Goddeeris B., Morrison W. I. Edited by Boca Raton: CRC Press;
    [Google Scholar]
  5. Borysiewicz L. K., Morris S., Page J. D., Sissons J. G. P. 1983; Human cytomegalovirus-specific cytotoxic T lymphocytes: requirements for in vitro generation and specificity. European Journal of Immunology 13:804–809
    [Google Scholar]
  6. Carmichael A., Jin X., Sissons P., Borysiewicz L. 1993; Quantitative analysis of the human immunodeficiency virus type 1 (HlV-l)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. Journal of Experimental Medicine 177:249–256
    [Google Scholar]
  7. Chenciner N., Michel F., Dadaglio G., Langlade-Demoyen P., Hoffenbach A., Leroux A., Garcia-Pons F., Rautmann G., Guy B., Guillon J.-M., Mayaud C., Girard M., Autran B., Kieny M.-P., Plata F. 1989; Multiple subset of HIV-specific cytotoxic T lymphocytes in humans and in mice. European Journal of Immunology 19:1537–1544
    [Google Scholar]
  8. Cremer K. J., Mackett M., Wohlenberg C., Notkins A. L., Moss B. 1985; Vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D prevents latent herpes in mice. Science 228:737–740
    [Google Scholar]
  9. Embretson J., Zupancic M., Ribas J. L., Burke A., Racz P., Tenner-Racz K., Haase A. T. 1993; Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature; London: 362359–362
    [Google Scholar]
  10. Evans C. W. 1993 A study of ovine γδ T cells Ph.D. thesis University of Edinburgh:
    [Google Scholar]
  11. Ezaki T., Miyasaka M., Beya M.-F., Dudler L., Trnka Z. 1987; A murine anti-sheep T8 monoclonal antibody, ST-8, that defines the cytotoxic T lymphocyte population. International Archives of Allergy and Applied Immunology 82:168–177
    [Google Scholar]
  12. Gendelman H. E., Narayan O., Molineaux S., Clements J. E., Ghotbi Z. 1985; Slow, persistent replication of lentiviruses: role of tissue macrophages and macrophage precursors in bone marrow. Proceedings of the National Academy of Sciences, U.S.A 82:7086–7090
    [Google Scholar]
  13. Gendelman H. E., Narayan O., Kennedy-Stoskopf S., Kennedy P. G. E., Ghotbi Z., Clements J. E., Stanley J., Pezeshkpour G. 1986; Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages. Journal of Virology 58:67–74
    [Google Scholar]
  14. Gorrell M. D., Brandon M. R., Sheffer D., Adams R. J., Narayan O. 1992; Ovine lentivirus is macrophagetropic and does not replicate productively in T lymphocytes. Journal of Virology 66:2679–2688
    [Google Scholar]
  15. Haase A. T. 1986; Pathogenesis of lentivirus infections. Nature; London: 322130–136
    [Google Scholar]
  16. Harkiss G. D., Watt N. J., King T. J., Williams J., Hopkins J. 1991; Retroviral arthritis: phenotypic analysis of cells in the synovial fluid of sheep with inflammatory synovitis associated with visna virus infection. Clinical Immunology and Immunopathology 60:106–117
    [Google Scholar]
  17. Hopkins J. 1991; Workshop studies on the ovine CD4 homologue. Veterinary Immunology and Immunopathology 27:101–102
    [Google Scholar]
  18. Houwers D. J. 1988; Monoclonal antibodies against zwoegerziekte virus. In Ovine Lentivirus Infections pp. 47–50 Thesis Centraal Diergeneeskundig Instituut (CDI), Lelystad, Netherlands:
    [Google Scholar]
  19. Jassoy C., Johnson R. P., Navia B. A., Worth J., Walker B. D. 1992; Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex. Journal of Immunology 149:3113–3119
    [Google Scholar]
  20. Kennedy-Stoskopf S. 1989; Pathogenesis of lentivirus-induced arthritis. Rheumatology International 9:129–136
    [Google Scholar]
  21. Kestens L., Vanham G., Gigase P., Young G., Hannet I., Vanlangendonck F., Hulstaert F., Bach B. A. 1992; Expression of activation antigens, HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection. AIDS 6:793–797
    [Google Scholar]
  22. Letvin N. L. 1991; Immune responses in lentivirus-infected animals. Current Opinion in Immunology 3:559–563
    [Google Scholar]
  23. Lichtensteiger C. A., Cheevers W. P., Davis W. C. 1993; CD8+ cytotoxic T lymphocytes against antigenic variants of caprine arthritis-encephalitis virus. Journal of General Virology 74:2111–2116
    [Google Scholar]
  24. Mackay C. R., Kimpton W. G., Brandon M. R., Cahill R. N. P. 1988; Lymphocyte subsets show marked differences in their distribution between blood and the afferent and efferent lymph of peripheral lymph nodes. Journal of Experimental Medicine 167:1755–1765
    [Google Scholar]
  25. Mackay C. R., Marston W. L., Dudler L., Spertini O., Tedder T. F., Hein W. R. 1992; Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells. European Journal of Immunology 22:887–895
    [Google Scholar]
  26. Mcmichael A. J., Gotch F. M., Noble G. R., Beare P. A. S. 1983; Cytotoxic T-cell immunity to influenza virus. New England Journal of Medicine 309:13–17
    [Google Scholar]
  27. Maddox J. F., Mackay C. R., Brandon M. R. 1985; Surface antigens, SBU-T4 and SBU-T8, of sheep T lymphocyte subsets defined by monoclonal antibodies. Immunology 55:739–748
    [Google Scholar]
  28. Miller M. D., Lord C. I., Stallard V., Mazzara G. P., Letvin N. L. 1990; The gag-specific cytotoxic T lymphocytes in Rhesus monkeys infected with the simian immunodeficiency virus of macaques. Journal of Immunology 144:122–128
    [Google Scholar]
  29. Narayan O., Wolinsky J. S., Clements J. E., Strandberg J. D., Griffin D. E., Cork L. C. 1982; Slow virus replication: the role of macrophages in the persistence and expression of visna viruses of sheep and goats. Journal of General Virology 59:345–356
    [Google Scholar]
  30. Nixon D. F. 1992; The cytotoxic T cell response to HIV. In Immunology of HIV Infection pp. 59–73 Bird A. G. Edited by Dordrecht: Kluwer Academic;
    [Google Scholar]
  31. Nixon D. F., Mcmichael A. J. 1991; Cytotoxic T cell recognition of HIV proteins and peptides. AIDS 5:1049–1059
    [Google Scholar]
  32. Pantaleo G., Graziosi C., Demarest J. F., Butini L., Montroni M., Fox C. H., Orenstein J. M., Kotler D. P., Fauci A. S. 1993; HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature; London: 362355–358
    [Google Scholar]
  33. Plata F., Autran B., Martins L. P., Wain-Hobson S., Raphael M., Mayaud C., Denis M., Guillon J.-M., Debre P. 1987; AIDS virus-specific cytotoxic T lymphocytes in lung disorders. Nature; London: 328348–351
    [Google Scholar]
  34. Reimann K. A., Snyder G. B., Chalifoux L. V., Waite B. C. D., Miller M. D., Yamamoto H., Spertini O., Letvin N. L. 1991; An activated CD8+ lymphocyte appears in lymph nodes of Rhesus monkeys early after infection with simian immunodeficiency virus. Journal of Clinical Investigation 88:1113–1120
    [Google Scholar]
  35. Reyburn H. T., Roy D. J., Blacklaws B. A., Sargan D. R., Watt N. J., Mcconnell I. 1992; Characteristics of the T cell- mediated immune response to maedi-visna virus. Virology 191:1009–1012
    [Google Scholar]
  36. Sargan D. R., Bennet I. D., Cousens C., Roy D. J., Blacklaws B. A., Dalziel R. G., Watt N. J., Mcconnell I. 1991; Nucleotide sequence of EV1, a British isolate of maedi-visna virus. Journal of General Virology 72:1893–1903
    [Google Scholar]
  37. Song W., Collisson E. W., Billingsley P. M., Brown W. C. 1992; Induction of feline immunodeficiency virus-specific cytolytic T-cell responses from experimentally infected cats. Journal of Virology 66:5409–5417
    [Google Scholar]
  38. Torsteinsdottir S., Georgsson G., Gisladottir E., Rafnar B., Palsson P. A., Petursson G. 1992; Pathogenesis of central nervous system lesions in visna: cell-mediated immunity and lymphocyte subsets in blood, brain, and cerebrospinal fluid. Journal of Neuroimmunology 41:149–158
    [Google Scholar]
  39. Venet A., Bourgault I., Aubertin A.-M., Kieny M.-P., Levy J. P. 1992; Cytotoxic T lymphocyte response against multiple simian immunodeficiency virus (SIV) proteins in SIV-infected macaques. Journal of Immunology 148:2899–2908
    [Google Scholar]
  40. Vowels B. R., Gershwin M. E., Gardner M. B., Ahmed-Ansari A., Mcgraw T. P. 1989; Characterization of simian immunodeficiency virus-specific T-cell-mediated cytotoxic response of infected rhesus macaques. AIDS 3:785–792
    [Google Scholar]
  41. Watret K. C., Whitelaw J. A., Froebel K. S., Bird A. G. 1993; Phenotypic characterization of CD8+ T cell populations in HIV disease and in anti-HIV immunity. Clinical and Experimental Immunology 92:93–99
    [Google Scholar]
  42. Watt N. J., Macintyre N., Collie D., Sargan D., Mcconnell I. 1992; Phenotypic analysis of lymphocyte populations in the lungs and regional lymphoid tissue of sheep naturally infected with maedi visna virus. Clinical and Experimental Immunology 90:204–208
    [Google Scholar]
  43. Yamamoto H., Miller M. D., Watkins D. I., Snyder G. B., Chase N. E., Mazzara G. P., Gritz L., Panicali D. L., Letvin N. L. 1990; Two distinct lymphocyte populations mediate simian immunodeficiency virus envelope-specific target cell lysis. Journal of Immunology 145:3740–3746
    [Google Scholar]
  44. Yamamoto H., Ringler D. J., Miller M. D., Yasutomi Y., Hasunuma T., Letvin N. L. 1992; Simian immunodeficiency virus-specific cytotoxic T lymphocytes are present in the AIDS-associated skin rash in rhesus monkeys. Journal of Immunology 149:728–734
    [Google Scholar]
  45. Yasutomi Y., Reimann K. A., Lord C. I., Miller M. D., Letvin N. L. 1993; Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected Rhesus monkeys. Journal of Virology 67:1707–1711
    [Google Scholar]
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