1887

Abstract

Mice congenic for the gene were infected intracerebrally with two scrapie strains, ME7 and 22A. At various times during the incubation period tissues were monitored for the infection-specific form of PrP (PrP). Prpsc was fond in brain, spleen, lymph nodes, pancreas, submaxillary gland and thymus. After intraperitoneal inoculation PrP was found in spleen, lymph nodes, pancreas and submaxillary glands prior to its detection in brain. The kinetics of accumulation of PrP in these tissues was dependent on the infecting strain of agent, on the mouse genotype and on the route of infection. This study supports using the presence of PrP as an indicator of infectivity in brain and extraneural tissues and defines some of the parameters which influence when and where PrP is first found.

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1994-03-01
2021-10-17
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