1887

Abstract

In addition to the seven known homologous regions () of multiple nucleocapsid polyhedrosis virus (AcMNPV) the dIII-K fragment was also found to carry a putative , although this fragment does not contain an . Deletion analysis showed that this contains several segments essential for its activity and other ‘auxiliary’ sequences that enhance the activity. Sequence analysis identified several structures often found in other viral replication , such as palindromes and other repeated motifs. Although most of the auxiliary sequences of this were found to be deleted in the nucleocapsid polyhedrosis virus genome, the essential part of this , containing the palindromes and the A/T-rich region, was retained. This and the fact that after prolonged serial passage of AcMNPV large replicating DNA molecules are found in which repeated sequences derived from the dIII-K fragment accumulate are consistent with this region being a putative origin of AcMNPV DNA replication.

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1994-12-01
2022-05-28
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References

  1. Anders D. G., Punturieri S. M. 1991; Multicomponent origin of cytomegalovirus lytic-phase DNA replication. Journal of Virology 65:931–937
    [Google Scholar]
  2. Anders D. G., Kacica M. A., Pari G. S., Punturieri S. M. 1992; Boundaries and structure of human cytomegalovirus oriLyt, a complex origin for lytic-phase DNA replication. Journal of Virology 66:3373–3384
    [Google Scholar]
  3. Blissard G. W., Rohrmann G. F. 1990; Baculovirus diversity and molecular biology. Annual Review of Entomology 35:127–155
    [Google Scholar]
  4. Cochran M. A., Faulkner P. 1983; Location of homologous DNA sequences interspersed at five regions in the baculovirus AcMNPV genome. Journal of Virology 45:961–970
    [Google Scholar]
  5. DePamphilis M. L. 1993; Eukaryotic DNA replication: anatomy of an origin. Annual Review of Biochemistry 62:29–63
    [Google Scholar]
  6. Francki R. I. B., Fauquet C. M., Knudson D. L., Brown F. editor 1991; Classification and nomenclature of viruses: fifth report of the International Committee on Taxonomy of Viruses. Archives of Virology Supplementum 2:1–450
    [Google Scholar]
  7. Friesen P. D., Miller L. K. 1987; Divergent transcription of early 35- and 94-kilodalton protein genes encoded by the HindIII-K genome fragment of the baculovirus Autographa californica nuclear polyhedrosis virus. Journal of Virology 61:2264–2272
    [Google Scholar]
  8. Friesen P. D., Nissen M. S. 1990; Gene organization and transcription of TED, a lepidopteran retrotransposon integrated within the baculovirus genome. Molecular and Cellular Biology 10:3067–3077
    [Google Scholar]
  9. Gregor P. D., Sawadogo M., Roeder R. G. 1990; The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. Genes Development 4:1730–1740
    [Google Scholar]
  10. Groebe D. R., Chung A. E., Ho C. 1990; Cationic lipid-mediated cotransfection of insect cells. Nucleic Acids Research 18:4033
    [Google Scholar]
  11. Guarino L. A., Gonzalez M. A., Summers M. D. 1986; Complete sequence and enhancer function of the homologous DNA regions of Autographa californica nuclear polyhedrosis virus. Journal of Virology 60:224–229
    [Google Scholar]
  12. Hink W. F. 1970; Established insect cell line from the cabbage looper, Trichoplusia ni . Nature; London: 226466–467
    [Google Scholar]
  13. Igaraschi K., Fawl R., Roller R. J., Roizman B. 1993; Construction and properties of a recombinant herpes simplex virus 1 lacking both S-component origins of DNA synthesis. Journal of Virology 67:2123–2132
    [Google Scholar]
  14. Kamita S. G., Majima K., Maeda S. 1993; Identification and characterization of the p3 5 gene of Bombyx mori nuclear polyhedrosis virus-induced apoptosis. Journal of Virology 67:455–463
    [Google Scholar]
  15. Kool M., Vlak J. M. 1993; The structural and functional organization of the Autographa californica nuclear polyhedrosis virus genome: an overview. Archives of Virology 130:1–16
    [Google Scholar]
  16. Kool M., Voncken J. W., Van Lier F. L. J., Tramper J., Vlak J. M. 1991; Detection and analysis of Autographa californica nuclear polyhedrosis virus mutants with defective interfering properties. Virology 183:739–746
    [Google Scholar]
  17. Kool M., Van Den Berg P. M. M. M., Tramper J., Goldbach R. W., Vlak J. M. 1993a; Location of two putative origins of DNA replication of Autographa californica nuclear polyhedrosis virus. Virology 192:94–101
    [Google Scholar]
  18. Kool M., Voeten J. T. M., Goldbach R. W., Tramper J., Vlak J. M. 1993b; Identification of seven putative origins of Autographa californica multiple nucleocapsid nuclear polyhedrosis virus DNA replication. Journal of General Virology 74:2661–2668
    [Google Scholar]
  19. Lee H. J., Krell P. J. 1992; Generation and analysis of defective genomes of Autographa californica nuclear polymedrosis virus. Journal of Virology 66:4339–4347
    [Google Scholar]
  20. Lee H. J., Krell P. J. 1994; Reiterated DNA fragments in defective genomes of Autographa californica nuclear polyhedrosis virus are competent for AcMNPV-dependent DNA replication. Virology 202:412–429
    [Google Scholar]
  21. Leisy D. J., Rohrmann G. F. 1993; Characterization of the replication of plasmids containing hr sequences in baculovirus infected Spodoptera frugiperda cells. Virology 196:722–730
    [Google Scholar]
  22. Longnecker R., Roizman B. 1986; Clustering of genes dispensable for growth in culture in the S component of the HSV-1 genome. Science 236:573–576
    [Google Scholar]
  23. Luckow V. L., Summers M. D. 1988; Trends in the development of baculovirus expression vectors. Bio/Technology 6:47–55
    [Google Scholar]
  24. Majima K., Kobara R., Maeda S. 1993; Divergence and evolution of homologous regions of Bombyx mori nuclear polyhedrosis virus. Journal of Virology 67:7513–7521
    [Google Scholar]
  25. Miller L. K. 1988; Baculoviruses as gene expression vectors. Annual Review of Microbiology 42:177–199
    [Google Scholar]
  26. Payne C. C. 1988; Pathogens for the control of insects: where next. Philosophical Transactions of the Royal Society of London 318:225–248
    [Google Scholar]
  27. Pearson M., Bjornson R., Pearson G., Rohrmann G. F. 1992; The Autographa californica baculovirus genome: evidence for multiple replication origins. Science 257:1382–1384
    [Google Scholar]
  28. Pearson M. N., Bjornson R. M., Ahrens C. H., Rohrmann G. F. 1993; Identification and characterization of a putative origin of DNA replication in the genome of a baculovirus pathogen for Orgyia pseudotsugata . Virology 197:715–725
    [Google Scholar]
  29. Polvino-Bodnar M., Orberg P. K., Schaffer P. A. 1987; Herpes simplex virus type 1 oriL is not required for virus replication or for the establishment and reactivation of latent infection in mice. Journal of Virology 61:3528–3535
    [Google Scholar]
  30. Rigby P. W. J., Dieckman M., Rhodes C., Berg P. 1977; Labelling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. Journal of Molecular Biology 113:237
    [Google Scholar]
  31. Rodems S. M., Friesen P. D. 1993; The hr5 transcriptional enhancer stimulates early expression from the Autographa californica nuclear polyhedrosis virus genome but is not required for virus replication. Journal of Virology 67:5776–5785
    [Google Scholar]
  32. Sambrook J., Fritsch E. F., Maniatis T. 1989 Molecular Cloning: A Laboratory Manual Cold Spring Harbor, New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
  33. Smith G. E., Summers M. D. 1978; Analysis of baculovirus genomes with restriction endonucleases. Virology 89:517–527
    [Google Scholar]
  34. Southern E. M. 1975; Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology 98:503–517
    [Google Scholar]
  35. Summers M. D., Smith G. E. 1987 A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures Texas Agricultural Experiment Station Bulletin no 1555
    [Google Scholar]
  36. Theilmann D. A., Stewart S. 1992; Tandemly repeated sequence at the 3′ end of the IE-2 gene of the baculovirus Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus is an enhancer element. Virology 187:97–106
    [Google Scholar]
  37. Vaughn J. L., Goodwin R. H., Tompkins G. J., McCawley P. 1977; The establishment of two cell lines from the insect Spodoptera frugiperda (Lepidoptera: Noctuidae). In Vitro 13:213–217
    [Google Scholar]
  38. Wickham T. J., Davis T., Granados R. R., Hammer D. A., Shuler M. L., Wood H. A. 1991; Baculovirus defective interfering particles are responsible for variations in recombinant protein production as a function of multiplicity of infection. Biotechnology Letters 13:483–488
    [Google Scholar]
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