1887

Abstract

The mechanism of iota-carrageenan (-CAR)-induced protection against murine cytomegalovirus (MCMV) infection of mice was analysed. The virus titres in the target organs on the fourth day correlated with that in the plasma at 1 h after intraperitoneal inoculation of MCMV, irrespective of -CAR treatment. Pretreatment of mice with -CAR induced infiltration of polymorphonuclear neutrophils into the peritoneal cavity and inhibition of viral spread from the peritoneal cavity to the plasma. Although the direct relationship of these two phenomena was unclear, the inhibition by -CAR of viral spread resulted in protection against MCMV infection of mice.

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1994-01-01
2022-01-23
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References

  1. Ebihara K., Minamishima Y. 1984; Protective effect of biological response modifiers on murine cytomegalovirus infection. Journal of Virology 51:117–122
    [Google Scholar]
  2. Eizuru Y., Minamishima Y., Hirano A., Kurimura T. 1978; Replication of mouse cytomegalovirus in thymidine kinase-deficient mouse cells. Microbiology and Immunology 22:755–764
    [Google Scholar]
  3. Eizuru Y., Nakagawa N., Hamasuna R., Minamishima Y. 1992; Protective effect of MDP-Lys (L18), a synthetic derivative of muramyldipeptide, on murine cytomegalovirus infection. Natural Immunity 11:225–236
    [Google Scholar]
  4. Gold E., Nankervis G. A. 1989; Cytomegalovirus. In Viral Infections of Humans: Epidemiology and Control pp 169–189 Evans A. S. Edited by New York & London: Plenum Press;
    [Google Scholar]
  5. Griffiths P. D. 1990; Cytomegalovirus. In Principles and Practice of Clinical Virology pp 69–102 Zuckerman A. J., Banatvala J. E., Pattison J. R. Edited by Chichester: John Wiley;
    [Google Scholar]
  6. Hamasuna R., Eizuru Y., Shishime Y., Minamishima Y. 1993; Protective effect of carrageenan against murine cytomegalovirus infection in mice. Antiviral Chemistry and Chemotherapy in press
    [Google Scholar]
  7. Ibusuki K., Minamishima Y. 1990; Effect of Chlorella vulgaris extracts on murine cytomegalovirus infections. Natural Immunity and Cell Growth Regulation 9:121–128
    [Google Scholar]
  8. Kalmar J. R., Arnold R. R., Warbington M. L., Gardner M. K. 1988; Superior leukocyte separation with a discontinuous one-step Ficoll-Hypaque gradient for the isolation of human neutrophils. Journal of Immunological Methods 110:275–281
    [Google Scholar]
  9. Mims C. A., Gould J. 1978; The role of macrophages in mice infected with murine cytomegalovirus. Journal of General Virology 41:143–153
    [Google Scholar]
  10. Minamishima Y., Eizuru Y., Yoshida A., Fukunishi R. 1978; Murine model for immunoprophylaxis of cytomegalovirus infection. I. Efficacy of immunization. Microbiology and Immunology 22:693–700
    [Google Scholar]
  11. Ohashi T., Yoshida A., Minamishima Y. 1988; Host-mediated antiviral activity of Lactobacillus casei against cytomegalovirus infection in mice. Biotherapy 1:27–39
    [Google Scholar]
  12. Ohashi T., Minamishima Y., Yokokura T., Mutai M. 1989; Induction of resistance in mice against murine cytomegalovirus by cellular components of Lactobacillus casei. Biotherapy 1:89–95
    [Google Scholar]
  13. Okada M., Minamishima Y. 1987a; The efficacy of biological response modifiers against murine cytomegalovirus infection in normal and immunodeficient mice. Microbiology and Immunology 31:45–57
    [Google Scholar]
  14. Okada M., Minamishima Y. 1987b; The effect of biological response modifiers on chronic and latent murine cytomegalovirus infections. Microbiology and Immunology 31:435–447
    [Google Scholar]
  15. Osborn J. E. 1982; Cytomegalovirus and other herpesviruses. In The Mouse in Biomedical Research II pp 267–292 Foster J. G., Small J. D., Fox J. G. Edited by New York: Academic Press;
    [Google Scholar]
  16. Whaley K., Burt A. D. 1992; Inflammation, healing and repair. In Muir’s Textbook of Pathology pp 112–165 Macsween R. N. M., Whaley K. Edited by London: Edward Arnold;
    [Google Scholar]
  17. Wish L., Furth J., Storey R. H. 1950; Direct determinations of plasma, cell, and organ-blood volumes in normal and hypervolemic mice. Proceedings of the Society for Experimental Biology and Medicine 74:644–648
    [Google Scholar]
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