1887

Abstract

Human herpesvirus 6 (HHV-6) induced nuclear antigens in cells as early as 3 h after infection. These nuclear antigens were induced by all three strains of HHV-6 tested, and their synthesis required the function(s) of the intact viral genome. Their appearance was not affected by 2,2′-anhydro(1-β--arabinofuranosyl)cytosine, but was completely inhibited by cycloheximide. However, the nuclear antigens did appear if cycloheximide was replaced with actinomycin D. Thus, the nuclear antigens seem to be equivalent to the immediate early antigens of other herpesviruses.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-73-8-2161
1992-08-01
2024-12-02
Loading full text...

Full text loading...

/deliver/fulltext/jgv/73/8/JV0730082161.html?itemId=/content/journal/jgv/10.1099/0022-1317-73-8-2161&mimeType=html&fmt=ahah

References

  1. Asada H., Yalcin Y., Balachandra K., Higashi K., Yamanishi K. 1989; Establishment of titration system for human herpesvirus 6 and evaluation of neutralizing antibody response to the virus. Journal of Clinical Microbiology 27:2204–2207
    [Google Scholar]
  2. Balachandran N., Amelse R. E., Zhou W. W., Chang C. K. 1989; Identification of proteins specific for human herpesvirus 6-infected human T cells. Journal of Virology 63:2835–2840
    [Google Scholar]
  3. Balachandran N., Tirawatnapong S., Pfeiffer B., Ablashi D. V., Salahuddin S. Z. 1991; Electrophoretic analysis of human herpesvirus 6 polypeptides immunoprecipitated from infected cells with human sera. Journal of Infectious Diseases 163:29–34
    [Google Scholar]
  4. Beth E., Giraldo G., Bernard M. 1976; Detection of immediate early, early and late antigens in herpes simplex virus infected cells. Biomedicine 25:366–368
    [Google Scholar]
  5. Di Luca D., Katsafanas G., Schirmer E. C., Balachandran N., Frankel N. 1990; The replication of viral and cellular DNA in human herpesvirus 6-infected cells. Virology 175:199–210
    [Google Scholar]
  6. Efstathiou S., Gompels U. A., Craxton M. A., Honess R. W., Ward K. 1988; DNA homology between a novel human herpesvirus (HHV-6) and human cytomegalovirus. Lancet i:63–64
    [Google Scholar]
  7. Geder L. 1976; Evidence for early nuclear antigens in cytomegalovirus-infected cells. Journal of General Virology 32:315–319
    [Google Scholar]
  8. Honess R. W., Roizman B. 1974; Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins. Journal of Virology 14:8–19
    [Google Scholar]
  9. Honess R. W., Roizman B. 1975; Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides. Proceedings of the National Academy of Sciences, U.S.A. 72:1274–1280
    [Google Scholar]
  10. Josephs S. F., Salahuddin S. Z., Ablashi D. V., Schachter F., Wong-Staal F., Gallo R. C. 1986; Genomic analysis of the human B-lymphotropic virus (HBLV). Science 234:601–603
    [Google Scholar]
  11. Lawrence G. L., Chee M., Craxton M. A., Gompels U. A., Honess R. W., Barrell B. G. 1990; Human herpesvirus 6 is closely related to human cytomegalovirus. Journal of Virology 64:287–299
    [Google Scholar]
  12. Lopez C., Pellett P., Stewart J., Goldsmith C., Sanderlin K., Black M. J., Warfield D., Feorino P. 1988; Characteristics of human herpesvirus-6. Journal of Infectious Diseases 157:1271–1273
    [Google Scholar]
  13. Lusso P., De Maria A., Mainati M., Lori F., DeRocco S. E., Baseler M., Gallo R. C. 1991; Induction of CD4 and susceptibility to HIV-1 infection by human herpesvirus 6. Nature, London 349:533–535
    [Google Scholar]
  14. Lusso P., Markham P. D., Tschachler E., Veronese F. M., Salahuddin S. Z., Ablashi D. V., Pahwa S., Krohn K., Gallo R. C. 1988; In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6). Journal of Experimental Medicine 167:1659–1700
    [Google Scholar]
  15. Martin M. E. D., Nicholas J., Thomson B. J., Newman C., Honess R. W. 1991; Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6. Journal of Virology 65:5381–5390
    [Google Scholar]
  16. Michelson-Fiske S., Horodniceanu F., Guillon J. C. 1977; Immediate early antigens in human cytomegalovirus infected cells. Nature, London 270:615–617
    [Google Scholar]
  17. Miyosyi I., Taguchi H., Kubonishi I., Yoshimoto S., Ohtsuki Y., Shiraishi Y., Akagi T. 1982; Type C virus-producing cell lines derived from adult T cell leukemia. GANN Monographs in Cancer Research 28:219–228
    [Google Scholar]
  18. Okuno T., Sao H., Asada H., Shiraki K., Takahashi M., Yamanishi K. 1990; Analysis of a glycoprotein of human herpesvirus 6 (HHV-6) using monoclonal antibodies. Virology 176:625–628
    [Google Scholar]
  19. Salahuddin S. Z., Ablashi D. V., Markham P. D., Josephs S. F., Sturzenegger S., Kaplan M., Halligan G., Boberfeld P., Wong-Staal F., Kramarsky B., Gallo R. C. 1986; Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234:596–601
    [Google Scholar]
  20. Shiraki K., Hyman R. W. 1987; The immediate early proteins of varicella-zoster virus. Virology 156:423–436
    [Google Scholar]
  21. Shiraki K., Okuno T., Yamanishi K., Takahashi M. 1989; Virion and nonstructural polypeptides of human herpesvirus-6. Virus Research 13:173–178
    [Google Scholar]
  22. Takahashi K., Sonoda S., Higashi K., Konodo T., Takahashi H., Takahashi M., Yamanishi K. 1989; Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. Journal of Virology 63:3161–3163
    [Google Scholar]
  23. Tanaka S., Otsuka M., Ihara S., Maeda F., Watanabe Y. 1979; Induction of pre-early nuclear antigen(s) in HEL cells infected with human cytomegalovirus. Microbiology and Immunology 23:263–271
    [Google Scholar]
  24. Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., Kurata T. 1988; Identification of human herpesvirus-6 as a casual agent for exanthem subitum. Lancet i:1065–1067
    [Google Scholar]
  25. Yoshida T., Yoshiyama H., Suzuki E., Harada S., Yanagi K., Yamamoto N. 1989; Immune response of patients with exanthem subitum to human herpesvirus type 6 (HHV-6) polypeptides. Journal of Infectious Diseases 160:901–902
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-73-8-2161
Loading
/content/journal/jgv/10.1099/0022-1317-73-8-2161
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error