1887

Abstract

Transcriptionally active human papillomavirus type 6a (HPV-6a) DNA was detected in a lung carcinoma of a patient with recurrent laryngeal papillomatosis. The carcinoma contained episomal HPV-6a genomes that had a duplication of the upstream regulatory region, the late region and a portion of the early region. HPV-6a genomes found in benign laryngeal papillomas from the same patient did not contain this duplication. A role for the mutant molecules in the pathogenesis of the malignancy is suggested.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-73-2-423
1992-02-01
2022-01-18
Loading full text...

Full text loading...

/deliver/fulltext/jgv/73/2/JV0730020423.html?itemId=/content/journal/jgv/10.1099/0022-1317-73-2-423&mimeType=html&fmt=ahah

References

  1. Androphy E. J., Hubbert N. L., Schiller J. T., Lowy D. R. 1987; Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines. EMBO Journal 6:989–992
    [Google Scholar]
  2. Bedell M. A., Jones K. H., Grossman S. R., Laimins L. A. 1989; Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells. Journal of Virology 63:1247–1255
    [Google Scholar]
  3. Boshart M., zur Hausen H. 1986; Human papillomaviruses in Buschke-Lowenstein tumors: physical state of the DNA and identification of a tandem duplication in the noncoding region of a human papillomavirus 6 subtype. Journal of Virology 58:963–966
    [Google Scholar]
  4. Byrne J. C., Tsao M. -S., Fraser R. S., Howley P. M. 1987; Human papillomavirus-11 DNA in a patient with chronic laryngotracheobronchial papillomatosis and metastatic squamous-cell carcinoma of the lung. New England Journal of Medicine 317:873–878
    [Google Scholar]
  5. Chirgwin J. M., Przybyla A. E., MacDonald R. J., Rutter W. J. 1979; Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294–5299
    [Google Scholar]
  6. Choo K.-B., Pan C.-C., Han S.-H. 1987; Integration of human papillomavirus type 16 into cellular DNA of cervical carcinoma: preferential deletion of the E2 gene and invariable retention of the long control region and the E6/E7 open reading frames. Virology 161:259–261
    [Google Scholar]
  7. Chow L. T., Nasseri M., Wolinsky S. M., Broker T. R. 1987; Human papillomavirus types 6 and 11 mRNAs from genital condylomata acuminata. Journal of Virology 61:2581–2588
    [Google Scholar]
  8. Crook T., Morgenstern J. P., Crawford L., Banks L. 1989; Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras. EMBO Journal 8:513–519
    [Google Scholar]
  9. de Villiers E.-M., Gissmann L., zur Hausen H. 1981; Molecular cloning of viral DNA from human genital warts. Journal of Virology 40:932–935
    [Google Scholar]
  10. Feinberg A. P., Vogelstein B. 1983; A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Analytical Biochemistry 132:6–13
    [Google Scholar]
  11. Kasher M. S., Roman A. 1988; Characterization of human papillomavirus type 6b DNA isolated from an invasive squamous carcinoma of the vulva. Virology 165:225–233
    [Google Scholar]
  12. Kaur P., McDougall J. K. 1988; Characterization of primary human keratinocytes transformed by human papillomavirus type 18. Journal of Virology 62:1917–1924
    [Google Scholar]
  13. Krieg P., Amtmann E., Sauer G. 1983; The simultaneous extraction of high-molecular-weight DNA and of RNA from solid tumors. Analytical Biochemistry 134:288–294
    [Google Scholar]
  14. Maxam A. M., Gilbert W. 1980; Sequencing end-labeled DNA with base-specific chemical cleavages. Methods in Enzymology 65:499–560
    [Google Scholar]
  15. Mounts P., Kashima H. 1984; Association of human papillomavirus subtype and clinical course in respiratory papillomatosis. Laryngoscope 94:28–33
    [Google Scholar]
  16. Pirisi L., Yasumoto S., Feller M., Doniger J., DiPaolo J. A. 1987; Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. Journal of Virology 61:1061–1066
    [Google Scholar]
  17. Rando R. F., Groff D. E., Chirikjian J. G., Lancaster W. D. 1986a; Isolation and characterization of a novel human papillomavirus type 6 DNA from an invasive vulvar carcinoma. Journal of Virology 57:353–356
    [Google Scholar]
  18. Rando R. F., Lancaster W. D., Han P., Lopez C. 1986b; The noncoding region of HPV-6vc contains two distinct transcriptional enhancing elements. Virology 155:545–556
    [Google Scholar]
  19. Rosen M., Auborn K. 1991; Duplication of the upstream regulatory sequences increases the transformation potential of human papillomavirus type 11. Virology 185:484–487
    [Google Scholar]
  20. Saiki R. K., Gelfand D. H., Stoffel S., Scharf S. J., Higuchi R., Horn G. T., Mullis K. B., Erlich H. A. 1988; Primer directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487–491
    [Google Scholar]
  21. Schneider-Gadicke A., Schwarz E. 1986; Different human cervical carcinoma cell lines show similar transcription patterns of human pápillomavirus type 18 early genes. EMBO Journal 5:2285–2292
    [Google Scholar]
  22. Schwarz E., Durst M., Demankowski C., Latterman O., Zech R., Wolfsperger E., Suhai S., zur Hausen H. 1983; DNA sequence and genome organization of genital human papillomavirus type 6b. EMBO Journal 2:2341–2348
    [Google Scholar]
  23. Schwarz E., Freese U. K., Gissmann L., Mayer W., Roggen-buck B., Stremlau A., zur Hausen H. 1985; Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature, London 314:111–114
    [Google Scholar]
  24. Seedorf K., Oltersdorf T., Krammer G., Rowekamp W. 1987; Identification of early proteins of the human papilloma viruses type 16 (HPV 16) and type 18 (HPV 18) in cervical carcinoma cells. EMBO Journal 6:139–144
    [Google Scholar]
  25. Smotkin D., Wettstein F. O. 1986; Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proceedings of the National Academy of Sciences, U.S.A. 83:4680–4684
    [Google Scholar]
  26. Southern E. M. 1975; Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology 98:503–517
    [Google Scholar]
  27. Steinberg B. M., Gallagher T., Stoler M. H., Abramson A. L. 1987; Relationship between human papillomavirus types in laryngeal papillomatosis and response to interferon-alpha. In CancerCells 5/Papillomaviruses pp 403–409 Edited by Steinberg B. M., Brandsma J. L., Taichman L. B. New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
  28. Watanabe S., Kanda T., Yoshiike K. 1989; Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7. Journal of Virology 63:965–969
    [Google Scholar]
  29. Watts S. L., Brewer E. E., Walton L. A. 1987; Cell-culture models for human papillomaviruses. In Cancer Cells 5/ Papillomaviruses pp 237–243 Edited by Steinberg B. M., Brandsma J. L., Taichman L. B. New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
  30. Wu T.-C., Mounts P. 1988; Transcriptional regulatory element in the noncoding region of human papillomavirus type 6. Journal of Virology 62:4722–4729
    [Google Scholar]
  31. Yutsudo M., Okamoto Y., Hakura A. 1988; Functional dissociation of transforming genes of human papillomavirus type 16. Virology 166:594–597
    [Google Scholar]
  32. Zarod A. P., Rutherford J. D., Corbitt G. 1988; Malignant progression of laryngeal papilloma associated with human papilloma virus type 6 (HPV-6) DNA. Journal of Clinical Pathology 41:280–283
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-73-2-423
Loading
/content/journal/jgv/10.1099/0022-1317-73-2-423
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error