1887

Abstract

In contrast to Lewis (LEW) and Wistar rats, black hooded (BH) rats inoculated with Borna disease (BD) virus developed neither encephalitis nor clinical disease despite persistent replication of the virus in the central nervous system. In comparison to LEW rats, production of virus-specific antibodies was significantly delayed in BD-resistant BH rats, even though identical titres were finally reached. The different susceptibility in LEW and BH rats was studied further by investigating responses of F hybrid animals. Although these rats developed encephalitis, they did not become sick. The differences in host responses for BD virus were found to be genetically determined but were independent of class I or class II major histocompatibility complex gene products or to genes responsible for lymphocyte differentiation.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-72-3-535
1991-03-01
2022-10-03
Loading full text...

Full text loading...

/deliver/fulltext/jgv/72/3/JV0720030535.html?itemId=/content/journal/jgv/10.1099/0022-1317-72-3-535&mimeType=html&fmt=ahah

References

  1. Anzil A. P., Blinzinger K., Mayr A. 1973; Persistent Borna virus infection in adult hamsters. Archiv für die gesamte Virusforschung 40:52–57
    [Google Scholar]
  2. Deschl U., Stitz L., Herzog S., Frese K., Rott R. 1990; Determination of immune cells and expression of MHC class II antigen in encephalitic lesions of experimental Borna disease. Acta neuropathologica 81:41–50
    [Google Scholar]
  3. Heinig A. 1969; Die Borna’sche Krankheit der Pferde und Schafe. In Handbuch der Virusinfektionen bei Tieren vol 4 pp 83–148 Edited by Rohrer H. Jena: VEB Gustav Fischer;
    [Google Scholar]
  4. Herzog S., Rott R. 1980; Replication of Borna disease virus in cell cultures. Medical Microbiology and Immunology 168:153–158
    [Google Scholar]
  5. Hirano N., Kao M., Ludwig H. 1983; Persistent, tolerant or subacute infection in Borna disease virus-infected rats. Journal of General Virology 64:1521–1530
    [Google Scholar]
  6. Kao M., Ludwig H., Gosztonyi G. 1984; Adaptation of Borna disease virus to the mouse. Journal of General Virology 65:1845–1849
    [Google Scholar]
  7. Lange H., Herzog S., Herbst W., Schliesser T. 1987; Seroepidemiologische Untersuchungen zur Boma’schen Krankheit (Ansteckende Gehirnund Rückenmarksinfektion) der Pferde. Tier-drztliche Umschau 42:938–946
    [Google Scholar]
  8. Lubaroff D. M., Butcher G., Dewitt C., Gill T. III, Gunther E., Howard J., Wonigeit K. 1983; Standardized nomenclature for the rat T-cell alloantigens: report of the committee. Transplantation Proceedings 2:16–83
    [Google Scholar]
  9. Ludwig H., Bode L., Gosztonyi G. 1988; Borna disease: a persistent vims infection of the central nervous system. Progress in Medical Virology 35:107–151
    [Google Scholar]
  10. Narayan O., Herzog S., Frese K., Scheefers H., Rott R. 1983a; Behavioral disease in rats caused by immunopathoiogical responses to persistent Borna vims in the brain. Science 220:1401–1403
    [Google Scholar]
  11. Narayan O., Herzog S., Frese K., Scheefers H., Rott R. 1983b; Pathogenesis of Borna disease in rats: immune–mediated viral ophthaimoencephalopathy causing blindness and behavioral abnormalities. Journal of Infectious Diseases 148:305–315
    [Google Scholar]
  12. Nitzschke E. 1963; Untersuchungen fiber die experimentelle Bomavims-infektion bei der Ratte. Zentralblatt für Veterinarmedizin B10:470–527
    [Google Scholar]
  13. Richt J. A., Stitz L., Wekerle H., Rott R. 1989; Borna disease, a progressive meningoencephalomyelitis as a model for CD4+ T cell-mediated immunopathology in the brain. Journal of Experimental Medicine 170:1045–1050
    [Google Scholar]
  14. Richt J., Stitz L., Deschl U., Frese K., Rott R. 1990; Borna disease vims-induced meningoencephalomyelitis caused by a virus-specific CD4+ T cell-mediated immune reaction. Journal of General Virology 71:2565–2573
    [Google Scholar]
  15. Rott R., Herzog S., Fleischer B., Winokur A., Amsterdam J., Dyson W., Koprowski H. 1985; Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science 228:755–756
    [Google Scholar]
  16. Rott R., Herzog S., Richt J., Stitz L. 1988; Immune-mediated pathogenesis of Borna disease. Zentralblatt für Bakteriologie und Hygiene A 270:295–301
    [Google Scholar]
  17. Wonigeit K. 1979a; Definition of lymphocyte antigens in rats: RT-Ly-1, RT-Ly-2, and a new MHC-linked antigen system. Transplantation Proceedings 2:1334–1336
    [Google Scholar]
  18. Wonigeit K. 1979b; Characterization of the RT-Ly-1 and RT-Ly-2 alloantigenic systems by congenic rat strains. Transplantation Proceedings 3:1631–1635
    [Google Scholar]
  19. Wonigeit K., Hedrich H. J., Gunther E. 1979; Serologic and histogenetic analysis of apparently identical RT1 haplotypes. Transplantation Proceedings 3:1584–1587
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-72-3-535
Loading
/content/journal/jgv/10.1099/0022-1317-72-3-535
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error