1887

Abstract

Bovine leukosis virus (BLV) is associated with the disease complex enzootic bovine leukosis. The infection may remain clinically silent in the form of an aleukaemic state or emerge as a persistent lymphocytosis and more rarely as lymphosacroma. BLV has been considered classically to be a B lymphotropic virus, based upon the absolute increase in B lymphocytes in persistent lymphocytosis, the B lymphocyte phenotype of a majority of the cells making up lymphosarcomas and the identification of viral antigen expressed in B lymphocytes following culture of peripheral blood mononuclear leukocytes. This association of BLV with B lymphocytes is well established but the mechanism(s) of disease expression is not defined. To examine further the cellular tropism(s) of BLV, T lymphocyte subpopulations from 10 lymphocytotic cattle were established . Lymphocyte cultures were characterized by their subpopulation phenotype and DNA was extracted for identification of integrated provirus by Southern blot hybridization. Provirus was identified in T lymphocyte cultures derived from seven of 10 lymphocytotic cattle, with both T helper and T cytotoxic/suppressor subpopulations affected.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-72-2-307
1991-02-01
2021-10-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/72/2/JV0720020307.html?itemId=/content/journal/jgv/10.1099/0022-1317-72-2-307&mimeType=html&fmt=ahah

References

  1. Baldwin C. L., Teale A. J., Naessens J. G., Goddeeris B. M., MacHugh N. D., Morrison W. I. 1986; Characterization of a subset of bovine T lymphocytes that express BoT4 by monoclonal antibodies and function: similarity to lymphocytes defined by human T4 and murine L3T4. Journal of Immunology 136:4385–4391
    [Google Scholar]
  2. Baldwin C. L., MacHugh N. D., Ellis J. A., Naessens J. G., Newson J., Morrison W. I. 1988; Monoclonal antibodies which react with bovine T-lymphocyte antigens and induce blastogenesis: tissue distribution and functional characteristics of the target antigens. Immunology 63:439–446
    [Google Scholar]
  3. Baliga V., Ferrer J. F. 1977; Expression of the bovine leukemia virus and its internal antigen in blood lymphocytes. Proceedings of the Society for Experimental Biology and Medicine 156:388–391
    [Google Scholar]
  4. Broeke A. V., Cleuter Y., Chen G., Portetelle D., Mammerickx M., Zagury D., Fouchard M., Coulombel L., Kettmann R. 1988; Even transcriptionally competent proviruses are silent in bovine leukemia virus-induced sheep tumor cells. Proceedings of the National Academy of Sciences, U.S.A 85:9263–9267
    [Google Scholar]
  5. Burny A., Bruck C., Cleuter Y., Couez D., Deschamps J., Gregoire D., Ghysdael J., Kettmann R., Mannerickx M., Marbaix G., Portetelle D. 1985; Bovine leukaemia virus and enzootic bovine leukosis. Onderstepoort Journal of Veterinary Research 52:133–144
    [Google Scholar]
  6. Close T. J., Rodriguez R. L. 1982; Construction and characterization of the chloramphenicol-resistance gene cartridge: a new approach to the transcriptional mapping of extrachromosomal elements. Gene 20:305–316
    [Google Scholar]
  7. Derse D. 1988; Trans-acting regulation of bovine leukemia virus mRNA processing. Journal of Virology 62:1115–1119
    [Google Scholar]
  8. Driscoll D. M., Olson C. 1977; Bovine leukemia virus associated antigens in lymphocyte cultures. American Journal of Veterinary Research 38:1897–1898
    [Google Scholar]
  9. Ellis J. A., Baldwin C. L., MacHugh N. D., Bensaid A., Teale A. J., Goddeeris B. M., Morrison W. I. 1986; Characterization by a monoclonal antibody and functional analysis of a subset of bovine T lymphocytes that express BoT8, a molecule analogous to human CD8. Immunology 58:351–358
    [Google Scholar]
  10. Gelmann E. P., Burny A., Kettmann R. 1984; Characterization of cellular sequences flanking an integrated bovine leukemia virus genome. Journal of Virology 52:988–990
    [Google Scholar]
  11. Ghysdael K., Bruck C., Kettmann R., Burny A. 1984; Bovine leukemia virus. Current Topics in Microbiology and Immunology 112:1–19
    [Google Scholar]
  12. Greene W. C., Leonard W. J., Wano Y., Svetlik B. P., Peffer N. J., Sodroski J. G., Rosen C. A., Goh W. C., Haseltine W. A. 1986; Transactivator gene of HTLV-I induces IL-2 receptor and IL-2 cellular gene expression. Science 232:877–880
    [Google Scholar]
  13. Greene W. C., Bohnlein E., Ballard D. W. 1989; HIV-1, HTLV-1 and normal T-cell growth: transcriptional strategies and surprises. Immunology Today 10:272–278
    [Google Scholar]
  14. Gregoire D., Couez D., Deschamps J., Heuertzhors-Cayla M. C., Szpirer J., Szpirer C., Burny A., Huez G., Kettmann R. 1984; Different bovine leukaemia virus-induced tumors harbor the provirus in different chromosomes. Journal of Virology 50:275–279
    [Google Scholar]
  15. Hare W. C. D., Yang T. H., McFeely R. A. 1967; A survey of chromosome findings in 47 cases of bovine lymphosarcoma (leukemia). Journal of the National Cancer Institute 38:383–387
    [Google Scholar]
  16. Katoh I., Yoshinaka Y., Sagata N., Ikawa Y. 1987; The bovine leukemia virus X region encodes a trans-activator of its long terminal repeat. Japanese Journal of Cancer Research (Gann) 78:93–98
    [Google Scholar]
  17. Kenyon S. J., Piper C. E. 1977; Cellular basis of persistent lymphocytosis in cattle infected with bovine leukemia virus. Infection and Immunity 16:891–897
    [Google Scholar]
  18. Kettmann R., Meunier-Rotival M., Cortadas J., Cuny G., Ghysdael J., Mammerickx M., Burny A., Bernardi G. 1979; Integration of bovine leukemia virus DNA in the bovine genome. Proceedings of the National Academy of Sciences, U.S.A 76:4822–4826
    [Google Scholar]
  19. Kettmann R., Cleuter Y., Mammerickx M., Meunier-Rotival M., Bernardi G., Burny A., Chantrenne H. 1980a; Genomic integration of bovine leukemia provirus: comparison of persistent lymphocytosis with lymph node tumor form of enzootic bovine leukosis. Proceedings of the National Academy of Sciences, U.S.A. 77:2577–2581
    [Google Scholar]
  20. Kettmann R., Marbaix G., Cleuter Y., Portetelle D., Mammerickx M., Burny A. 1980b; Genomic integration of bovine leukemia provirus and lack of viral RNA expression in the target cells of cattle with different responses to BLV infection. Leukemia Research 4:509–519
    [Google Scholar]
  21. Kettman R., Couez D., Burny A. 1981; Restriction endonuclease mapping of linear unintegrated proviral DNA of bovine leukemia virus. Journal of Virology 38:27–33
    [Google Scholar]
  22. Kettmann R., Deschamps J., Cleuter Y., Couez D., Burny A., Marbaix G. 1982; Leukemogenesis by bovine leukemia virus: proviral DNA integration and lack of RNA expression of viral long terminal repeat and 3′ proximate cellular sequences. Proceedings of the National Academy of Sciences, U.S.A. 79:2465–2469
    [Google Scholar]
  23. Kettmann R., Deschamps J., Couez D., Claustriaux J., Palm R., Burny A. 1983; Chromosome integration domain for bovine leukemia provirus in tumors. Journal of Virology 47:146–150
    [Google Scholar]
  24. Kumar S. P., Paul P. S., Pomeroy K. A. 1978; Frequency of lymphocytes bearing Fc receptors and surface membrane immunoglobulins in normal, persistent lymphocytotic and leukemic cows. American Journal of Veterinary Research 39:45–49
    [Google Scholar]
  25. Leung K., Nabel G. J. 1988; HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-к B-like factor. Nature, London 333:776–778
    [Google Scholar]
  26. Onuma M., Honma T., Mikami T., Ichijo S., Konishi T. 1979; Studies on the sporadic and enzootic forms of bovine leukosis. Journal of Comparative Pathology 89:159–167
    [Google Scholar]
  27. Onuma M., Sagata N., Okada K., Ogawa Y., Ikawa Y., Oshima I. 1982; Integration of bovine leukemia virus DNA in the genomes of bovine lymphosarcoma cells. Microbiology and Immunology 26:813–820
    [Google Scholar]
  28. Paul P. S., Pomeroy K. A., Castro A. I., Johnson D. W., Muscoplat C. C., Sorensen D. K. 1977a; Detection of bovine leukemia virus in B-lymphocytes by the syncytia induction assay. Journal of the National Cancer Institute 59:1269–1272
    [Google Scholar]
  29. Paul P. S., Pomeroy K. A., Johnson D. W., Muscoplat C. C., Handwerger B. S., Soper F. F., Sorensen D. K. 1977b; Evidence for the replication of bovine leukemia virus in B lymphocytes. American Journal of Veterinary Research 38:873–876
    [Google Scholar]
  30. Redelman D. 1987; Simultaneous increased expression of E-rosette receptor (CD2, T11) and T cell growth factor receptor on human T lymphocytes during activation. Cytometry 8:170–183
    [Google Scholar]
  31. Rice N. R., Simek S. L., Dubois G. S., Showalter S. D., Gilden R. V., Stephens R. M. 1987; Expression of the bovine leukemia virus X region in virus-infected cells. Journal of Virology 61:1577–1585
    [Google Scholar]
  32. Rosen C. A., Sodroski J. G., Willems L., Kettmann R., Campbell K., Zaya R., Burny A., Haseltine W. A. 1986; The 3′ region of bovine leukemia virus encodes a transactivator protein. EMBO Journal 5:2585–2589
    [Google Scholar]
  33. Sagata N., Yasunaga T., Tsuzuku-Kawamura J., Ohishi K., Ogawa Y., Ikawa Y. 1985; Complete nucleotide sequence of the genome of bovine leukemia virus: its evolutionary relationship to other retroviruses. Proceedings of the National Academy of Sciences, U.S.A. 82:677–681
    [Google Scholar]
  34. Thurmond M. C., Holmberg C. A., Picanso J. P. 1985; Antibodies to bovine leukemia virus and presence of malignant lymphoma in slaughtered California dairy cattle. Journal of the National Cancer Institute 74:711–714
    [Google Scholar]
  35. Thurmond M. C., Carter R. L., Picanso J. P., Stralka K. 1990; Upper normal prediction limits of lymphocyte counts for cattle not infected with bovine leukemia virus. American Journal of Veterinary Research 51:466–470
    [Google Scholar]
  36. Williams D. L., Amborski G. F., Davis W. C. 1988a; Enumeration of T and B lymphocytes in bovine leukemia virus-infected cattle, using monoclonal antibodies. American Journal of Veterinary Research 49:1098–1103
    [Google Scholar]
  37. Williams D. L., Barta O., Amborski G. F. 1988b; Molecular studies of T-lymphocytes from cattle infected with bovine leukemia virus. Veterinary Immunology and Immunopathology 19:307–323
    [Google Scholar]
  38. Wyatt C. R., Wingett D., White J. S., Buck C. D., Knowles D., Reeves R., Magnuson N. S. 1989; Persistent infection of rabbits with bovine leukemia virus associated with development of immune dysfunction. Journal of Virology 63:4498–4506
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-72-2-307
Loading
/content/journal/jgv/10.1099/0022-1317-72-2-307
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error