We have identified the major immunogenic structural proteins of the human foamy virus (HFV), a distinct member of the foamy virus subfamily of . Radiolabelled viral proteins were immunoprecipitated from HFV-infected cells by foamy virus antisera of human and non-human primate origin. Precipitated viral proteins were in the range of 31K to 170K. Labelling of proteins with [C]glucosamine or with [S]methionine in the presence of tunicamycin, as well as endo-β--acetylglycosaminidase H and F treatment of [S]methionine-labelled proteins, revealed three viral glycoproteins of approximately 170K, 130K and 47K, most likely representing the gene-encoded precursor, the surface glycoprotein and the transmembrane protein of HFV, respectively.


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