1887

Abstract

Summary

Using plasmids containing sequences complementary to the genes that code for oligo-2′,5′-adenylate synthetase, actin and H4 histone, we have shown that although interferon does not affect the accumulation of RNA transcripts of the actin and H4 histone genes, it activates the accumulation of RNA transcripts of the oligo-2′,5′-adenylate synthetase gene. However, interferon inhibits the accumulation of RNA transcripts of simian virus 40 (SV40) genes in SV40-infected cells.

Keyword(s): 2-5AS , interferon(HuIFN-α) and SV40
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-70-5-1267
1989-05-01
2021-10-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/70/5/JV0700051267.html?itemId=/content/journal/jgv/10.1099/0022-1317-70-5-1267&mimeType=html&fmt=ahah

References

  1. Benech R., Mory Y., Revel M., Chebath J. 1985; Structure of two forms of the IFN-induced 2′-5′ oligo(A)synthetase of human cells based on cDNA and gene expression. EMBO Journal 4:2249–2256
    [Google Scholar]
  2. Daher K. A., Samuel C. E. 1982; Mechanism of interferon action. Differential effect of interferon on the synthesis of SV40 and reovirus polypeptides in monkey kidney cells. Virology 117:379–390
    [Google Scholar]
  3. Fyrberg E. A., Kindle K. L., Davidson N. 1980; The actin genes of drosophila: a dispersed multigene family. Cell 19:365–378
    [Google Scholar]
  4. Kerr M. J., Brown R. E. 1978; pppA2p5A2p5A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells. Proceedings of the National Academy of SciencesU.S.A 75:256–260
    [Google Scholar]
  5. Khandiian E. W. 1986; UV crosslinking of RNA to nylon membrane enhances hybridization signals. Molecular Biology Reporter 11:107–115
    [Google Scholar]
  6. Lengyel P. 1981; Biochemistry of interferons and their actions. In Interferon 377–91 Gresser I. New York & London: Academic Press;
    [Google Scholar]
  7. Merlin G., Chebath I., Benech P., Metz R., Revel M. 1983; Molecular cloning and sequence of partial cDNA for interferon induced (2′-5′)oligo A synthetase mRNA from human cells. Proceedings of the National Academy of SciencesU.S.A 80:4904–4908
    [Google Scholar]
  8. Metz D. H., Levin M. I., Ozman M. N. 1976; Mechanism of interferon action: further evidence for transcription as a primary site of action in simian virus 40 infection. Journal of General Virology 32:227–240
    [Google Scholar]
  9. Mozes L. W., Defendi V. 1979; The differential effect of interferon on T-antigen production in SV40-infected or transformed cells. Virology 93:558–568
    [Google Scholar]
  10. Revel M., Kimchi A., Shulman L., Fradin A., Shuster R., Jakobson E., Chernajorsky Y., Schmidt A., Shure A., Bendori R. 1980; Role of interferon-induced enzymes in the antiviral and antimitogenic effects of interferon. Annals of the New York Academy of Science 305:459–472
    [Google Scholar]
  11. Roberts W. K., Hovanessian A., Brown R. E., Clemens M. I., Kerr M. J. 1976; Interferon-mediated protein kinase and low-molecular weight inhibitor of protein synthesis. Nature, London 264:477–480
    [Google Scholar]
  12. Schmidt A., Chernajovsky W. Y., Shulman L., Federman P., Berissi H., Revel M. 1979; An interferon- induced phosphodiesterase degrading (2′-5′) oligoisoadenylate and the CCA terminus of tRNA. Proceedings of the National Academy of SciencesU.S.A 76:4788–4792
    [Google Scholar]
  13. Slattery E., Ghosh N., Samanta H., Lengyel P. 1979; Interferon double-stranded RNA and RNA degradation: activation of an endonuclease by (2′-5′). Proceedings of the National Academy of SciencesU.S.A 76:4778–4782
    [Google Scholar]
  14. Stark R. G., Dower J. W., Schimke T. R., Brown E. R., Kerry M. J. 1979; 2′-5′ synthetase :assay, distribution and variation with growth or hormone status. Nature, London 278:471–473
    [Google Scholar]
  15. Yamamoto K., Yamaguchi N., Oda K. 1975; Mechanism of interferon-induced inhibition of early simian virus 40 (SV40) functions. Virology 68:58–70
    [Google Scholar]
  16. Zilberstein A., Kimschi A., Schmidt A., Revel M. 1978; Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligoisoadenylate synthetase. Proceedings of the National Academy of SciencesU.S.A 75:4734–4738
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-70-5-1267
Loading
/content/journal/jgv/10.1099/0022-1317-70-5-1267
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error