1887

Abstract

Summary

We have constructed a selectable Friend murine leukaemia virus (F-MuLV) with a suppressor tRNA () gene integrated into the proviral long terminal repeat. The viral construct was infectious and pathogenic and retained the marker gene when growing or . Only a few integration sites of the provirus were detected by Southern blot analysis of the DNA of erythroleukaemic cells. These results indicate that F-MuLV-induced erythroleukaemia is of clonal origin and suggest that insertional mutagenesis is involved in pathogenesis.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-69-10-2663
1988-10-01
2019-10-18
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-69-10-2663
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error