1887

Abstract

Summary

We have constructed a selectable Friend murine leukaemia virus (F-MuLV) with a suppressor tRNA () gene integrated into the proviral long terminal repeat. The viral construct was infectious and pathogenic and retained the marker gene when growing or . Only a few integration sites of the provirus were detected by Southern blot analysis of the DNA of erythroleukaemic cells. These results indicate that F-MuLV-induced erythroleukaemia is of clonal origin and suggest that insertional mutagenesis is involved in pathogenesis.

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/content/journal/jgv/10.1099/0022-1317-69-10-2663
1988-10-01
2022-01-23
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