The study of common colds, especially in volunteers, has occupied me for much of my scientific career and has constantly provided new and fascinating insights to someone like myself who is interested in human disease and how it is produced. But the study has also led me to investigate the biology of some fascinating organisms and to work with novel scientific ideas and methods. Progress has been real, though at times spasmodic, and has introduced me to many interesting and agreeable colleagues and collaborators both here and abroad, who, of course, have done most of the actual work. Whatever the public may think, we have passed a number of significant thresholds. I believe that eventually the prevention and specific treatment of colds will become practical and I hope to be around to see that day.


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