1887

Abstract

Summary

Reassortment is an important factor in the evolution of segmented genome viruses. For arthropod-borne viruses it is important to determine whether the vertebrate host acts as a site of reassortant virus formation since vertebrates often act as amplifying hosts. Mutants of Thogoto virus, a tick-borne orthomyxo-like virus, were shown to produce wild-type progeny in a dually infected permissive host (hamster), when hamsters were infected with two mutant viruses either by direct inoculation or by oral transmission from infected ticks. Viral dose and time of co-infection of the host affected the incidence of reassortment. This is the first report of reassortment of an arbovirus following infection of a vertebrate host via an arthropod vector.

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/content/journal/jgv/10.1099/0022-1317-68-5-1299
1987-05-01
2019-10-16
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-68-5-1299
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