1887

Abstract

Summary

Secretory IgA (sIgA) and IgG from porcine milk and serum, respectively, [H]uridine-labelled virus, swine testis and pig kidney cell lines were used to examine the neutralized virus-cell interaction. Transmissible gastroenteritis virus (TGEV), 99.99% neutralized by immunoglobulin, was able to attach to the cells. Moreover, sIgA enhanced virus attachment. However, the neutralized virus was unable to enter cells, as demonstrated by the action of proteinase K which removed it from the cell surface. It was also found that pre-attached virus was still neutralizable and that IgG and sIgA had similar TGEV-neutralizing capacities.

Keyword(s): attachment , neutralization and TGEV
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/content/journal/jgv/10.1099/0022-1317-67-5-939
1986-05-01
2022-09-25
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