1887

Abstract

Summary

The long terminal repeat (LTR) of Rauscher murine leukaemia virus (MuLV) has been sequenced. It differs in only three positions from the LTR of Rauscher spleen focus-forming virus (SFFV), and in four positions from the LTR of Rauscher mink cell focus-inducing virus (MCFV). It is unlikely that these differences account for differences in leukaemogenicity or tissue tropism of Rauscher MuLV, SFFV and MCFV. In contrast to the LTR of Friend MuLV, the Rauscher MuLV LTR contains only one copy of a tandem direct repeat. This repeat includes an enhancer core sequence.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-67-12-2785
1986-12-01
2022-01-17
Loading full text...

Full text loading...

/deliver/fulltext/jgv/67/12/JV0670122785.html?itemId=/content/journal/jgv/10.1099/0022-1317-67-12-2785&mimeType=html&fmt=ahah

References

  1. Bestwick R. K., Boswell B. A., Kabat D. 1984; Molecular cloning of biologically active Rauscher spleen focus-forming virus and the sequences of its env gene and long terminal repeat. Journal of Virology 51:695–705
    [Google Scholar]
  2. Chatis P. A., Holland C. A., Silver J. E., Frederickson T. N., Hopkins N., Hartley J. W. 1984; A 3′ end fragment encompassing the transcriptional enhancers of nondefective Friend virus confers erythroleukemo-genicity on Moloney leukemia virus. Journal of Virology 52:248–254
    [Google Scholar]
  3. Cloyd M. W. 1983; Characterization of target cells for MCF viruses in AKR mice. Cell 32:217–225
    [Google Scholar]
  4. Corcoran L. M., Adams J. M., Dunn A. R., Cory S. 1984; Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion. Cell 37:113–122
    [Google Scholar]
  5. Cuypers H. T., Selten G., Quint W., Zijlstra M., Robanus Maandag E., Boelens W., Van Weezenbeek P., Melief C., Berns A. 1984; Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell 37:141–150
    [Google Scholar]
  6. De Both N. J., Stoof T. J., Kranendonk M., Stoker K., Vonk W. P., Mol J. N. M. 1985; The induction of myeloid leukaemias by Rauscher murine leukaemia virus. Journal of General Virology 66:909–913
    [Google Scholar]
  7. Desgroseillers L., Jolicoeur P. 1984a; Mapping the viral sequences conferring leukemogenicity and disease specificity in Moloney and amphotropie murine leukemia viruses. Journal of Virology 52:448–456
    [Google Scholar]
  8. Desgroseillers L., Jolicoeur P. 1984b; The tandem direct repeats within the long terminal repeat of murine leukemia viruses are the primary determinant of their leukemogenic potential. Journal of Virology 52:945–952
    [Google Scholar]
  9. Evans L. H., Cloyd M. W. 1985; Friend and Moloney murine leukemia viruses specifically recombine with different endogenous retroviral sequences to generate mink cell focus-forming viruses. Proceedings of the National Academy of Sciences, U.S.A. 82:459–463
    [Google Scholar]
  10. Habara A., Reddy E. P., Aaronson S. A. 1982; Rauscher murine leukemia virus: molecular cloning of infectious integrated proviral DNA. Journal of Virology 44:731–735
    [Google Scholar]
  11. Hartley J. W., Rowe W. P. 1975; Clonal cell lines from a feral mouse embryo which lack host-range restrictions for murine leukemia viruses. Virology 65:128–134
    [Google Scholar]
  12. Hayward W. S., Neel B. G., Astrin S. A. 1981; Activation of a cellular one gene by promoter insertion in ALV-induced lymphoid leukosis. Nature, London 290:475–480
    [Google Scholar]
  13. Hirt B. 1967; Selective extraction of polyoma DNA from infected mouse cell cultures. Journal of Molecular Biology 26:365–369
    [Google Scholar]
  14. Koch W., Zimmermann W., Oliff A., Friedrich R. 1984; Molecular analysis of the envelope gene and long terminal repeat of Friend mink cell focus-inducing virus: implications for the functions of these sequences. Journal of Virology 49:828–840
    [Google Scholar]
  15. Linemeyer D. L., Menke J. G., Ruscetti S. K., Evans L. H., Scolnick E. M. 1982; Envelope gene sequences which encode the gp 52 protein of spleen focus-forming virus are required for the induction of erythroid cell proliferation. Journal of Virology 43:223–233
    [Google Scholar]
  16. Lovinger G. G., Schochetman G. 1979; 5′-Terminal nucleotide sequences of the Rauscher leukemia virus and gibbon ape leukemia virus genomes exhibit a high degree of correspondence. Journal of Virology 32:803–811
    [Google Scholar]
  17. Mol J. N. M., Ostertag W., Bilello J., Stoof T. J. 1982; Rauscher spleen focus-forming virus: biological properties and relationship to helper viruses. Journal of General Virology 63:45–56
    [Google Scholar]
  18. Nusse R., Varmus H. E. 1982; Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31:99–109
    [Google Scholar]
  19. Oliff A., Signorelli K., Collins L. 1984; The envelope gene and long terminal repeat sequences contribute to the pathogenic phenotype of helper-independent Friend viruses. Journal of Virology 51:788–794
    [Google Scholar]
  20. Oliff A., McKinney M. D., Agranovsky O. 1985; Contribution of the gag and pol sequences to the leukemogenicity of Friend murine leukemia virus. Journal of Virology 54:864–868
    [Google Scholar]
  21. Rassart E., Shang M., Boie Y., Jolicoeur P. 1986; Studies on emerging radiation leukemia virus variants in C57BL/Ka mice. Journal of Virology 58:96–106
    [Google Scholar]
  22. Rosen C. A., Haseltine W. A., Lenz J., Ruprecht R., Cloyd M. W. 1985; Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences. Journal of Virology 55:862–866
    [Google Scholar]
  23. Sanger F., Nicklen S., Coulson A. R. 1977; DNA sequencing with chain-terminating inhibitors. Proceedings of the National Academy of Sciences, U.S.A. 74:5463–5467
    [Google Scholar]
  24. Selten G., Cuypers H. T., Zijlstra M., Melief C., Berns A. 1984; Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation. EMBO Journal 3:3215–3222
    [Google Scholar]
  25. Silver J., Kozak C. 1986; Common proviral integration region on mouse chromosome 7 in lymphomas and myelogenous leukemias induced by Friend murine leukemia virus. Journal of Virology 57:526–533
    [Google Scholar]
  26. Steeves R. A. 1975; Spleen focus-forming virus in Friend and Rauscher leukemia virus preparations. Journal of the National Cancer Institute 54:289–297
    [Google Scholar]
  27. Steffen D. 1984; Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas. Proceedings of the National Academy of Sciences, U.S.A. 81:2097–2101
    [Google Scholar]
  28. Troxler D. H., Scolnick E. M. 1978; Rapid leukemia induced by cloned Friend strain of replicating murine type-C virus. Virology 85:17–27
    [Google Scholar]
  29. Tsichlis P. N., Strauss P. G., Hu L. F. 1983; A common region for proviral DNA integration in MoMuLV-induced rat thymic lymphomas. Nature, London 302:445–449
    [Google Scholar]
  30. Van Griensven L. I. L. D., Vogt M. 1980; Rauscher ‘mink cell focus-inducing’ (MCF) virus causes erythroleukemia in mice: its isolation and properties. Virology 101:376–388
    [Google Scholar]
  31. Varmus H. E. 1982; Form and function of retroviral proviruses. Science 216:812–820
    [Google Scholar]
  32. Vogt M., Haggblom C., Swift S., Haas M. 1985; Envelope gene and long terminal repeat determine the different biological properties of Rauscher, Friend and Moloney mink cell focus-inducing viruses. Journal of Virology 55:184–192
    [Google Scholar]
  33. Weiher H., Köning M., Gruss P. 1983; Multiple point mutations affecting the simian virus 40 enhancer. Science 219:626–631
    [Google Scholar]
  34. Wolff L., Ruscetti S. 1986; Tissue tropism of a leukemogenic murine retrovirus is determined by sequences outside of the long terminal repeats. Proceedings of the National Academy of Sciences, U.S.A. 83:3376–3380
    [Google Scholar]
  35. Wolff L., Kaminchik J., Hankins W. D., Ruscetti S. K. 1985; Sequence comparisons of the anemia-and polycythemia-inducing strains of Friend spleen focus-forming virus. Journal of Virology 53:570–578
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-67-12-2785
Loading
/content/journal/jgv/10.1099/0022-1317-67-12-2785
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error