Independent Regulation of the Antiviral States Induced by MuIFN-α/β and by MuIFN-γ

The stability profiles of the antiviral states induced in L-929 cells against mengovirus by murine interferons MuIFN-α/β and by MuIFN-γ were shown to be different. Treatment of cells with combinations of IFN-α/β and IFN-γ have previously been shown to result in a potentiated expression of the antiviral state. Here we report studies of the stabilities of the antiviral states induced by various combinations of IFN-α/β and IFN-γ and that the regulation of the antiviral states induced by IFN-α/β and IFN-γ were independent of each other.