1887

Abstract

SUMMARY

Previous work has shown that fever in influenza of ferrets occurs following release of endogenous pyrogen from virus-phagocyte interaction in the upper respiratory tract (URT), and suggested that the poor inflammatory response and correspondingly low fever elicited by A/Puerto Rico/8/34 (H1N1), compared with H3N2 reassortant clones of A/Puerto Rico/8/34-A/England/939/69, were related to its H1 and N1 surface antigens. Nasal virus levels, inflammatory and pyrexial responses produced in ferrets by clones 31 (H3N1) and 64b (H1N2) of the same reassortant system suggested a connection between the H1 antigen and low inflammatory response, but results were not conclusive. Unlike A/Puerto Rico/8/34, two recent H1N1 isolates, A/USSR/90/77 and A/Fiji/15899/83, produced a high inflammatory response yet low fever despite large amounts of virus in the URT, suggesting that either no connection exists between the acquisition of the H1 antigen and production of a low inflammatory response, or the H1 antigen of recent isolates, whilst antigenically related to that of A/Puerto Rico/8/34, is biologically different.

Keyword(s): ferrets , fever and influenza virus
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-66-7-1627
1985-07-01
2024-05-10
Loading full text...

Full text loading...

/deliver/fulltext/jgv/66/7/JV0660071627.html?itemId=/content/journal/jgv/10.1099/0022-1317-66-7-1627&mimeType=html&fmt=ahah

References

  1. Campbell D., Sweet C., Smith H. 1979; Comparisons of virulence of influenza virus recombinants in ferrets in relation to their behaviour in man and their genetic constitution. Journal of General Virology 44:37–44
    [Google Scholar]
  2. Dinarello C. A., Wolff S. M. 1982; Exogenous pyrogens. In Pyretics and Antipyretics pp 73–112 Edited by Milton A. S. New York: Springer-Verlag;
    [Google Scholar]
  3. Fenner F., McAuslan B. R., Mims C. A., Sambrook J., White D. O. 1974 The Biology of Animal Viruses 2nd edn London: Academic Press;
    [Google Scholar]
  4. Gander G. W. 1982; Endogenous pyrogens. In Pyretics and Antipyretics pp 113–123 Edited by Milton A. S. New York: Springer-Verlag;
    [Google Scholar]
  5. Matsuyama T., Sweet C., Collie M. H., Smith H. 1980; Aspects of virulence in ferrets exhibited by influenza virus recombinants of known genetic constitution. Journal of Infectious Diseases 141:351–361
    [Google Scholar]
  6. Oxford L. S., McGeoch D. J., Schild G. C., Beare A. S. 1978; Analysis of virion RNA segments and polypeptides of influenza A virus recombinants of defined virulence. Nature, London 273:778–779
    [Google Scholar]
  7. Rawlins M. D., Cranston W. I. 1973; Clinical studies on the pathogenesis of fever. In The Pharmacology of Thermoregulation pp 264–277 Edited by Schonbaum E., Lomax P. Basel: S. Karger;
    [Google Scholar]
  8. Sweet C., Stephen J., Smith H. 1974; Purification of influenza viruses using disulphide-linked immunosorbents derived from rabbit antibody. Immunochemistry 11:295–304
    [Google Scholar]
  9. Sweet C., Bird R. A., Cavanagh D., Toms G. L., Collie M. H., Smith H. 1979; The local origin of the febrile response induced in ferrets during respiratory infection with a virulent influenza virus. British Journal of Experimental Pathology 60:300–308
    [Google Scholar]
  10. Toms G. L., Bird R. A., Kingsman S. M., Sweet C., Smith H. 1976; The behaviour in ferrets of two closely related clones of influenza virus of differing virulence for man. British Journal of Experimental Pathology 57:37–48
    [Google Scholar]
  11. Toms G. L., Davies J. A., Woodward C. G., Sweet C., Smith H. 1977; The relation of pyrexia and nasal inflammatory response to virus levels in the nasal washings of ferrets infected with influenza viruses of differing virulence. British Journal of Experimental Pathology 58:444–458
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-66-7-1627
Loading
/content/journal/jgv/10.1099/0022-1317-66-7-1627
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error