1887

Abstract

SUMMARY

Herpes simplex virus (HSV)-susceptible mice inoculated under conditions favouring the preferential activation of T suppressor (Ts) cells acting on the delayed-type hypersensitivity (DTH) response to the virus were protected from lethal herpes encephalitis and from central nervous system (CNS) demyelination (as reflected by ear paralysis), compared to controls given normal priming. Thus, suppressed DTH was not incompatible with recovery from acute infection and may indeed have been beneficial. Protection could be transferred by T cells from donors given a ‘DTH-tolerogenic’ priming regime. It was unlikely that protection resulted from enhancement of other mechanisms such as cytotoxic T cell activation, antibody or interferon production, since no reduction of virus spread was observed in protected mice. In addition, several aspects of Ts cell activation by intravenous inoculation of avirulent HSV type 1 have been characterized. Suppression was virus dose-dependent and could be transferred to the efferent limb of a DTH response. Activation of Ts cells for DTH coincided with an enhanced antibody response. It is suggested that protection in this model may be mediated by Ts cells which act to limit DTH-mediated immunopathology in the CNS.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-66-6-1297
1985-06-01
2022-01-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/66/6/JV0660061297.html?itemId=/content/journal/jgv/10.1099/0022-1317-66-6-1297&mimeType=html&fmt=ahah

References

  1. Allen W. P., Rapp F. 1982; Concept review of genital herpes vaccines. Journal of Infectious Diseases 145:413–421
    [Google Scholar]
  2. Altmann D. M., Blyth W. A. 1984; Lipopolysaccharide-induced suppressor cells for delayed-type hypersensitivity to herpes simplex virus: nature of suppressor cell and effect on pathogenesis of herpes simplex. Immunology 53:473–479
    [Google Scholar]
  3. Blyth W. A., Harbour D. A., Hill T. J. 1980; Effect of immunosuppression on recurrent herpes simplex in mice. Infection and Immunity 29:902–907
    [Google Scholar]
  4. Hill T. J., Field H. J., Blyth W. A. 1975; Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease. Journal of General Virology 28:341–353
    [Google Scholar]
  5. Hill T. J., Blyth W. A., Harbour D. A. 1978; Trauma to the skin causes recurrence of herpes simplex in the mouse. Journal of General Virology 39:21–28
    [Google Scholar]
  6. Hill T. J., Blyth W. A., Harbour D. A., Berrie E. L., Tullo A. B. 1983; Latency and other consequences of infection of the nervous system with herpes simplex virus. Progress in Brain Research 59:173–184
    [Google Scholar]
  7. Julius W. H., Simpson E., Herzenberg L. A. 1973; A rapid method for the isolation of functional thymus-derived murine lymphocytes. European Journal of Immunology 3:645–649
    [Google Scholar]
  8. Liew F. Y., Russell S. M. 1983; Inhibition of pathogenic effect of effector T cells by specific suppressor T cells during influenza virus infection in mice. Nature, London 304:541–543
    [Google Scholar]
  9. Liew F. Y., Russell S. M., Brand C. M. 1979; Induction and characterization of delayed type hypersensitivity to influenza virus in mice. European Journal of Immunology 9:783–790
    [Google Scholar]
  10. Nagafuchi S., Oda H., Mori R., Taniguchi T. 1979; Mechanism of acquired resistance to herpes simplex virus infection as studied in nude mice. Journal of General Virology 44:715–723
    [Google Scholar]
  11. Nahmias A. J., Hirsch M. S., Kramer J. H., Murphy F. A. 1969; Effect of antithymocyte serum on herpes virus hominis (type 1) infection in adult mice. Proceedings of the Society for Experimental Biology and Medicine 132:696–698
    [Google Scholar]
  12. Nash A. A., Ashford N. P. N. 1982; Split T-cell tolerance in herpes simplex virus-infected mice and its implication for antiviral immunity. Immunology 45:761–767
    [Google Scholar]
  13. Nash A. A., Cell P. G. H. 1983; Membrane phenotype of murine delayed effector and suppressor T cells involved in delayed hypersensitivity and protective immunity to herpes simplex virus. Cellular Immunology 75:348–355
    [Google Scholar]
  14. Nash A. A., Phelan J., Gell P. G. H., Wildy P. 1981; Tolerance and immunity in mice infected with herpes simplex virus: studies on the mechanism of tolerance to delayed-type hypersensitivity. Immunology 43:363–369
    [Google Scholar]
  15. O’reilly R. J., Chibbaro A., Anger E., Lopez C. 1977; Cell-mediated immune responses in patients with recurrent herpes simplex infections. II. Infection associated deficiency of lymphokine production in patients with recurrent herpes labialis or herpes progenitalis. Journal of Immunology 118:1095–1102
    [Google Scholar]
  16. Rager-zisman B. R., Allison A. C. 1976; Mechanism of immunologic resistance to herpes simplex virus 1 infection. Journal of Immunology 116:35–40
    [Google Scholar]
  17. Schrier R. D., Pizer L. I., Moorhead J. E. 1983; Tolerance and suppression of immunity to herpes simplex virus: different presentations of antigens induce different types of suppressor cells. Infection and Immunity 40:514–522
    [Google Scholar]
  18. Sheridan J. F., Donnenberg A. D., Aurelian L., Elpern D. J. 1982; Immunity to herpes simplex virus type 2. IV. Impaired lymphokine production during recrudescence correlates with an imbalance in T lymphocyte subsets. Journal of Immunology 129:326–331
    [Google Scholar]
  19. Townsend J. J. 1981; The demyelinating effect of corneal HSV infections in normal and nude (athymic) mice. Journal of the Neurological Sciences 50:435–441
    [Google Scholar]
  20. Townsend J. J., Baringer J. R. 1979; Morphology of the CNS disease in immunosuppressed mice after peripheral HSV infection. Laboratory Investigation 40:178–182
    [Google Scholar]
  21. Watanabe R., Wege H., Ter meulen V. 1983; Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis. Nature, London 305:150–153
    [Google Scholar]
  22. Zawatzky R., Hilfenhaus J., Kirchner H. 1979; Resistance of nude mice to herpes simplex virus and correlation with in vitro production of interferon. Cellular Immunology 47:424–428
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-66-6-1297
Loading
/content/journal/jgv/10.1099/0022-1317-66-6-1297
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error