1887

Abstract

SUMMARY

Components of herpes simplex virus remained bound to the diploid cell membrane after nucleocapsid penetration into the cytosol. These components enabled the infected cells to induce interferon-alpha (IFN-α) in peripheral blood mononuclear cells even when the infected cells were fixed by glutaraldehyde. Monoclonal antibodies directed against the major viral glycoprotein D could neutralize their IFN-α-inducing capacity. Thus, the process of IFN induction does not require uptake and penetration of the inducer into the effector cells. The process was, however, sensitive to lysosomotropic drugs. These data suggest that a membrane receptor is involved in the IFN-α induction mechanism.

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1985-12-01
2022-01-28
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References

  1. Abb J., Abb H., Kienhardt F. 1983; Phenotype of human alpha-interferon producing leucocytes identified by monoclonal antibodies. Clinical and Experimental Immunology 52:179–184
    [Google Scholar]
  2. Bishop G. A., Glorioso J. C., Schwartz S. A. 1983a; Role of interferon in human natural killer activity against target cells infected with HSV-1. Journal of Immunology 131:1849–1853
    [Google Scholar]
  3. Bishop G. A., Glorioso I. C., Schwartz S. A. 1983b; Relationship between expression of herpes simplex virus glycoproteins and susceptibility of target cells to human natural killer activity. Journal of Experimental Medicine 157:1544–1561
    [Google Scholar]
  4. Bishop G. A., Marlin S. D., Schwartz S. A., Glorioso J. C. 1984; Human natural killer cell recognition of herpes simplex virus type 1 glycoprotein: specificity analysis with the use of monoclonal antibodies and antigenic variants. Journal of Immunology 133:2206–2214
    [Google Scholar]
  5. Capobianchi M. R., Facchini J., DI Marco P., Antonelli G., Dianzani F. 1985; Induction of alpha interferon by membrane interaction between viral surface and peripheral blood mononuclear cells. Proceedings of the Society for Experimental Biology and Medicine 178:551–556
    [Google Scholar]
  6. Catalano L. W., Safley G. M., Museles M., Jarzynsk D. J. 1971; Disseminated herpes virus infection in a newborn infant. Virologic, serologic, coagulation and interferon studies. Journal of Pediatrics 79:393–397
    [Google Scholar]
  7. Dussaix E., Lebon P., Ponsot G., Huault G., Tardieu M. 1985; Intrathecal synthesis of different alpha-interferons in children with various neurological disorders. Acta neurologica scandinavica 71:504–509
    [Google Scholar]
  8. Eisenberg R. J., Long D., Ponce DE Leon M., Matthews J. T., Spear P. G., Gibson M. G., Lasky L. A., Berman P., Goluls E., Cohen G. H. 1985; Localization of epitopes of herpes simplex type 1 glycoprotein. Journal of Virology 53:634–644
    [Google Scholar]
  9. Fan D. P., Sefton B. M. 1978; The entry into host cells of Sindbis virus, vesicular stomatitis virus and Sendai virus. Cell 15:985–922
    [Google Scholar]
  10. Friedman H. M., Cohen G. H., Eisenberg R. J., Seidel C. A., Cines D. B. 1984; Glycoprotein C of herpes simplex virus 1 acts as a receptor for the C3b complement component on infected cells. Nature, London 309:633–635
    [Google Scholar]
  11. Goldstein J. L., Anderson B. G., Brown M. S. 1979; Coated pits, coated vesicles and receptor-mediated endocytosis. Nature, London 279:679–685
    [Google Scholar]
  12. Green J. A., Yeh T. J., Overall J. C. 1981; Sequential production of IFN-alpha and immune specific IFN-gamma by human mononuclear leukocytes exposed to herpes simplex virus. Journal of Immunology 127:1192–1196
    [Google Scholar]
  13. Haahr S., Rasmussen L., Merigan T. C. 1976; Lymphocyte transformation and interferon production in human mononuclear cell microcultures for assay of cellular immunity to herpes simplex virus. Infection and Immunity 14:47–54
    [Google Scholar]
  14. Hamano K., Ponsot G., Lebon P., Gerbaut L., Plouin P., Arthuis M. 1983; Encephalites herpetiques du nourisson et de l’enfant. Methodes de diagnostic. Archives franqaises de pediatric 40:709–714
    [Google Scholar]
  15. Hilfenhaus J., Ackerman R. 1981; Endogenous interferon in the cerebrospinal fluid of herpes encephalitis patients. Proceedings of the Society for Experimental Biology and Medicine 166:205–209
    [Google Scholar]
  16. Ito M., Barron A. L. 1972; Surface antigen produced by herpes simplex virus (HSV). Journal of Immunology 108:711–718
    [Google Scholar]
  17. Kirchner H., Peter H. H., Hirt H. M., Zawatzky R., Dalugge H., Bradstreet P. 1979; Studies of the producer cell of interferon in human lymphocyte cultures. Immunobiology 156:65–75
    [Google Scholar]
  18. Kohl S., Harmon M. W. 1983; Human neonatal leukocyte interferon production and natural killer cytotoxicity in response to herpes simplex virus. Journal of Interferon Research 3:461–463
    [Google Scholar]
  19. Lebon P., Ponsot G., Aicardi J., Goutieres F., Arthuis M. 1979; Early intrathecal synthesis of interferon in herpes encephalitis. Biomedicine 31:267–271
    [Google Scholar]
  20. Lebon P., Commoy-Chevalier M. J., Robert-Galliot B., Morin A., Chany C. 1980; Production d’interferon humain de type I par des lymphocytes au contact de cellules infectees par le virus herpes et fixees par le glutaraldehyde. Comptes rendus hebdomadaires des seances de I’Academie des sciences, serie D 290:37–40
    [Google Scholar]
  21. Lebon P., Bernard A., Boumsell L. 1982a; Identification de populations lymphocytaires productrices d’interferon-alpha par des anticorps monoclonaux. Comptes rendus hebdomadaires des seances de I’Academie des sciences, serie C 295:79–82
    [Google Scholar]
  22. Lebon P., Commoy-Chevalier M. J., Robert-Galliot B., Chany C. 1982b; Different mechanisms for alpha and beta interferon induction. Virology 119:504–507
    [Google Scholar]
  23. Legapsi R. C., Gatmaitan B., Baily E. J., Lerner A. M. 1980; Interferon in biopsy and autopsy specimens of brain: its presence in herpes simplex virus encephalitis. Archives of Neurology 37:76–79
    [Google Scholar]
  24. Leppla S. H., Dorland R. B., Middlebrook J. L. 1980; Inhibition of diphtheria toxin degradation and cytotoxic action by chloroquine. Journal of Biological Chemistry 255:2247–2250
    [Google Scholar]
  25. Long D., Madara T. J., Ponce DE Leon M., Cohen G. H., Montgomery P. C., Eisenberg R. J. 1984; Glycoprotein D protects mice against lethal challenge with herpes simplex virus types 1 and 2. Infection and Immunity 37:761–764
    [Google Scholar]
  26. Marsh M., Bolzau E., Helenius A. 1983; Penetration of Semliki Forest virus from acidic prelysosomal vacuoles. Cell 32:931–940
    [Google Scholar]
  27. Noble A. G., Lee T. Y., Sprague R., Parish M. L., Spear P. G. 1983; Anti-gD monoclonal antibodies inhibit cell fusion induced by herpes simplex virus type 1. Virology 129:218–224
    [Google Scholar]
  28. Overall J. C. JR, Spruance S. L., Green J. A. 1981; Viral induced leukocyte interferon in vesicle fluid from lesions of recurrent herpes labialis. Journal of Infectious Diseases 143:543–547
    [Google Scholar]
  29. Para P. F., Baucke R. B., Spear P. G. 1982; Glycoprotein gE of herpes simplex virus type 1: effects of anti-gE on virion infectivity and on virus-induced Fc-binding receptors. Journal of Virology 41:129–136
    [Google Scholar]
  30. Show Alter S. D., Zweig M., Hampar B. 1981; Monoclonal antibodies to herpes simplex virus type 1 proteins, including the immediate-early protein ICP 4. Infection and Immunity 34:684–692
    [Google Scholar]
  31. Steinman R. M., Mellman I. S., Muller W. A., Cohn Z. A. 1983; Endocytosis and the recycling of plasma membrane. Journal of Cell Biology 96:1–27
    [Google Scholar]
  32. Svitlik C., Marcus P. I. 1984; Interferon induction by viruses. XI Early events in the induction process. Journal of Interferon Research 4:585–602
    [Google Scholar]
  33. Vezinet F., Lebon P., Amoury C., Gibert C. 1981; Synthese d’interferon au cours des encephalites herpetiques de l’adulte. Nouvelle Presse Medicate 10:1135–1138
    [Google Scholar]
  34. Yasukawa M., Zarling J. M. 1983; Autologous herpes simplex virus-infected cells are lysed by human natural killer cells. Journal of Immunology 131:204–216
    [Google Scholar]
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