1887

Abstract

SUMMARY

The dynamics of scrapie agent replication in brain and spleen following intracerebral or intraperitoneal infection were investigated in a model with particularly long incubation periods [IM mice ( ) infected with 87V scrapie]. In contrast to other mouse scrapie models previously investigated, there was no delay in onset of replication (‘zero phase’) in spleen using either route of infection, For both routes infectivity levels reached a plateau in spleen, which was maintained for at least 250 days in intraperitoneally infected mice. An infectivity plateau was also apparent in brain following intracerebral infection, suggesting that there may be constraints on agent replication in brain during the later part of the incubation period. In addition, the efficiency of the intraperitoneal route to produce disease was found to be particularly low for this model.

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1985-12-01
2022-12-06
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References

  1. Bruce M. E., Dickinson A. G. 1985; Genetic control of amyloid plaque production and incubation period in scrapie-infected mice. Journal of Neuropathology and Experimental Neurology 44:285–294
    [Google Scholar]
  2. Collis S. C. 1983 Pathogenesis of scrapie: changes in IgG in selected models of scrapie in mice Ph. D. thesis University of Surrey;
    [Google Scholar]
  3. Collis S. C., Kimberlin R. H. 1985; Long term persistence of scrapie infection in mouse spleens in the absence of clinical disease. FEMS Microbiology Letters 29:111–114
    [Google Scholar]
  4. Dickinson A. G., Fraser H. 1969; Genetical control of the concentration of ME7 scrapie agent in mouse spleen. Journal of Comparative Pathology 79:363–366
    [Google Scholar]
  5. Dickinson A. G., Fraser H. 1977; Scrapie pathogenesis in inbred mice: an assessment of host control and response involving many strains of agent. In Slow Virus Infections of the Central Nervous System pp 3–14 Edited by Ter Meulen V., Katz M. New York: Springer-Verlag;
    [Google Scholar]
  6. Dickinson A. G., Meikle V. M. H. 1971; Host-genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent. Molecular and General Genetics 112:73–79
    [Google Scholar]
  7. Dickinson A. G., Outram G. W. 1979; The scrapie replication-site hypothesis and its implications for pathogenesis. In Slow Transmissible Diseases of the Nervous System vol 2: pp 13–31 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
  8. Dickinson A. G., Meikle V. M. H., Fraser H. 1968; Identification of a gene which controls the incubation period of some strains of scrapie in mice. Journal of Comparative Pathology 78:293–299
    [Google Scholar]
  9. Dickinson A. G., Meikle V. M. H., Fraser H. 1969; Genetical control of the concentration of ME7 scrapie agent in the brain of mice. Journal of Comparative Pathology 79:15–22
    [Google Scholar]
  10. Dickinson A. G., Fraser H., Outram G. W. 1975; Scrapie incubation period can exceed natural lifespan. Nature, London 256:732–733
    [Google Scholar]
  11. Eklund C. M., Kennedy R. C., Hadlow W. J. 1967; Pathogenesis of scrapie infection in the mouse. Journal of Infectious Diseases 117:15–22
    [Google Scholar]
  12. Fraser H., Bruce M. E. 1983; Experimental control of cerebral amyloid in scrapie in mice. In Immunology of Nervous System Infections pp 281–290 Edited by Behan P. O., Ter Meulen V., Rose F. C. Amsterdam: Elsevier;
    [Google Scholar]
  13. Fraser H., Dickinson A. G. 1968; The sequential development of the brain lesions of scrapie in three strains of mice. Journal of Comparative Pathology 78:301–311
    [Google Scholar]
  14. Fraser H., Dickinson A. G. 1973; Scrapie in mice: agent-strain differences in the distribution and intensity of grey matter vacuolation. Journal of Comparative Pathology 83:29–40
    [Google Scholar]
  15. Kimberlin R. H. 1979; Early events in the pathogenesis of scrapie in mice: biological and biochemical studies. In Slow Transmissible Diseases of the Nervous System vol 2: pp 33–54 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
  16. Kimberlin R. H., Walker C. A. 1978; Pathogenesis of mouse scrapie: effect of route of inoculation on infectivity titres and dose-response curves. Journal of Comparative Pathology 88:39–47
    [Google Scholar]
  17. Kimberlin R. H., Walker C. A. 1979a; Pathogenesis of mouse scrapie: dynamics of agent replication in spleen, spinal cord and brain after injection by different routes. Journal of Comparative Pathology 89:551–562
    [Google Scholar]
  18. Kimberlin R. H., Walker C. A. 1979b; Pathogenesis of scrapie: agent multiplication in brain at the first and second passage of hamster scrapie in mice. Journal of General Virology 42:107–117
    [Google Scholar]
  19. Kimberlin R. H., Walker C. A. 1980; Pathogenesis of mouse scrapie: evidence for neural spread of infection to the CNS. Journal of General Virology 51:183–187
    [Google Scholar]
  20. Kimberlin R. H., Walker C. A. 1982; Pathogenesis of mouse scrapie: patterns of agent replication in different parts of the CNS following intraperitoneal infection. Journal of the Royal Society of Medicine 75:618–624
    [Google Scholar]
  21. Kimberlin R. H., Walker C. A. 1983; Invasion of the CNS by scrapie agent and its spread to different parts of the brain. In Virus Non conventionnels et Affections du Systeme Nerveux Central pp 17–33 Edited by Court L. A., Cathala F. Paris: Masson;
    [Google Scholar]
  22. Kuroda Y., Gibbs C. J., Amyx H. L., Gajdusek D. C. 1983; Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes. Infection and Immunity 41:154–161
    [Google Scholar]
  23. Parker R. C. 1961 In Methods of Tissue Culture pp 245–266 London: Pitman;
    [Google Scholar]
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