1887

Abstract

Summary

A subcellular system actively replicating Kilham rat virus DNA was developed. Cellular lysates and isolated nuclei from infected cells showed an amplification of replicative forms . Solubilized replicative complexes, either partly purified or in the form of a crude extract, were able to synthesize replicative forms and single-stranded DNA. DNA polymerase α played a major role in Kilham rat virus DNA synthesis and . Furthermore, a factor present in the cytosol of infected cells increased the polymerizing activity of viral replicative complexes.

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/content/journal/jgv/10.1099/0022-1317-65-11-2021
1984-11-01
2019-10-23
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-65-11-2021
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