1887

Abstract

SUMMARY

Small- and large-plaque-producing viruses were selected from the enterovirus 71 (E71) prototype, BrCr. The small-plaque virus was a temperature-resistant () strain which could multiply at 39.5 °C as well as 35 °C. The large-plaque virus was temperature-sensitive () and could not grow at 39.5 °C. It was shown that the strain was much less neurovirulent for monkeys than the strain. Both and strains reacted with homologous and heterologous antibodies in cross-neutralization tests. While no difference was found between and strains in the size of virion polypeptides, the VP1 polypeptide could be differentiated by isoelectric focusing. Genomic differences between the two strains were found by oligonucleotide mapping.

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/content/journal/jgv/10.1099/0022-1317-64-2-499
1983-02-01
2022-01-24
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