1887

Abstract

Summary

Mouse cytomegalovirus (MCMV) grew to higher titres in spleen, liver, kidney and salivary gland of mice, and caused more sickness and death in susceptible (CD1) mice following treatment with anti-interferon globulin (AIG). In the resistant (C3H) strain of mice, organ titres were higher following AIG treatment but there was no sickness or mortality. Spleen necrosis was more severe in AIG-treated mice, indicating that this necrosis was not caused by interferon-mediated activation of natural killer (NK) cells. CD1 mice developed a high level of NK activity during MCMV infection and this was greatly reduced by AIG treatment. AIG was equally effective in increasing virus titres in NK-deficient beige (bg/bg) C57 B1.6 mice which showed a low level of NK activity even after MCMV infection, suggesting that interferon protects against MCMV by its direct antiviral effect on cells rather than by activating NK cells.

Keyword(s): CMV , interferon , NK cells and resistance
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-64-2-461
1983-02-01
2019-10-14
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-64-2-461
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error