1887

Abstract

SUMMARY

Mouse cytomegalovirus (MCMV) grew to higher titres in spleen, liver, kidney and salivary gland of mice, and caused more sickness and death in susceptible (CD1) mice following treatment with anti-interferon globulin (AIG). In the resistant (C3H) strain of mice, organ titres were higher following AIG treatment but there was no sickness or mortality. Spleen necrosis was more severe in AIG-treated mice, indicating that this necrosis was not caused by interferon-mediated activation of natural killer (NK) cells. CD1 mice developed a high level of NK activity during MCMV infection and this was greatly reduced by AIG treatment. AIG was equally effective in increasing virus titres in NK-deficient beige (bg/bg) C57 B1.6 mice which showed a low level of NK activity even after MCMV infection, suggesting that interferon protects against MCMV by its direct antiviral effect on cells rather than by activating NK cells.

Keyword(s): CMV , interferon , NK cells and resistance
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/content/journal/jgv/10.1099/0022-1317-64-2-461
1983-02-01
2024-05-04
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References

  1. Bancroft G. J., Shellam G. R., Grundy Chalmer J. E. 1981; Genetic influences on the augmentation of natural killer (NK) cells during murine cytomegalovirus infection: correlation with patterns of resistance. Journal of Immunology 126:988–995
    [Google Scholar]
  2. Chong K. T., Gould J. J., Mims C. A. 1981; Neutralization of different strains of murine cytomegalovirus (MCMV) - effect of in vitro passage. Archives of Virology 69:95–104
    [Google Scholar]
  3. Gidlund M., Orn A., Wigzell H., Senik A., Gresser I. 1978; Enhanced NK cell activity in mice injected with interferon and interferon inducers. Nature, London 273:759–761
    [Google Scholar]
  4. Gresser I., Tovey M. G., Bandu M. T., Maury C., Brouty-Boye D. 1976a; Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. Journal of Experimental Medicine 144:1305–1315
    [Google Scholar]
  5. Gresser I., Tovey M. G., Maury C., Bandu M.T. 1976b; Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, Newcastle disease and influenza viruses. Journal of Experimental Medicine 144:1316
    [Google Scholar]
  6. Grundy Chalme J. E., Trapman J., Allan J. E., Shellam G. R., Melief C. J. M. 1982; Evidence for a protective role of interferon in resistance to murine cytomegalovirus and its control by non-H-2-linked genes. Infection and Immunity 37:143–150
    [Google Scholar]
  7. Herberman R. B., Ortaldo J. R., Bonnard G. D. 1979; Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity. Nature, London 277:221–223
    [Google Scholar]
  8. Kern E. R., Olsen G. A., Overall J. C., Glasgow L. A. 1978; Treatment of a murine cytomegalovirus infection with exogenous interferon, polyinosinic-polycytidylic acid and polyinosinic-polycytidylic acid – poly-l-lysine complex. Antimicrobial Agents and Chemotherapy 13:344–346
    [Google Scholar]
  9. Mims C. A., Gould J. 1978; Splenic necrosis in mice infected with cytomegalovirus. Journal of Infectious Diseases 137:587–591
    [Google Scholar]
  10. Oie H. K., Easton J. M., Ablashi D. V., Baron S. 1975; Murine cytomegalovirus. Induction of and sensitivity to interferon in vitro. Infection and Immunity 11:1012–1017
    [Google Scholar]
  11. Osborn J. E., Medearis D. N. 1966; Studies of relationship between mouse cytomegalovirus and interferon. Proceedings of the Society for Experimental Biology and Medicine 121:819–824
    [Google Scholar]
  12. Quinnan G. V., Manischewitz J. F., Kirmani N. 1982; Involvement of natural killer cells in the pathogenesis of murine cytomegalovirus interstitial pneumonitis and the immune response to infection. Journal of General Virology 58:173–180
    [Google Scholar]
  13. Shellam G. R., Allan J. E., Papadimitriou J. M., Bancroft G. J. 1981; Increased susceptibility to cytomegalovirus infection in beige mutant mice. Proceedings of the National Academy of Sciences of the United States of America 78:5104–5108
    [Google Scholar]
  14. Tarr G. C., Armstrong J. A., Ho M. 1978; Production of interferon and serum hyporeactivity factor in mice infected with murine cytomegalovirus. Infection and Immunity 19:903–907
    [Google Scholar]
  15. Trinchieri G., Santoli D., Koprowski H. 1978; Spontaneous cell-mediated cytotoxicity in humans: role of interferon and immuno-globulins. Journal of Immunology 120:1849–1855
    [Google Scholar]
  16. Virelizier J. L., Gresser I. 1978; Role of interferon in the pathogenesis of viral diseases of mice as demonstrated by the use of anti-interferon serum. V. Protective role in mouse hepatitis virus type 3. Infection of susceptible and resistant strains of mice. Journal of Immunology 120:1616–1619
    [Google Scholar]
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