When primary infection with murine cytomegalovirus (MCMV) was by the intravenous route, the resulting delayed type hypersensitivity (DTH) to MCMV was reduced compared with subcutaneous or intraperitoneal infection. Intravenous injection of 10 or more p.f.u. of MCMV also reduced the DTH response to virus injected at the same time subcutaneously. When spleen cells from mice injected intravenously with MCMV 1 to 3 weeks earlier were transferred to subcutaneously infected mice, the resulting DTH response was suppressed. The cells responsible were T cells, being non-adherent and Thy-1 positive; they were not destroyed by complement plus antibody to either Lyt-1 or Lyt-2. Suppression was not transferred by serum. The suppression was antigen-specific; DTH responses induced by sheep red blood cells and by a thymidine kinase-negative strain of herpes simplex virus type 1 were not significantly suppressed by concurrent intravenous infection with MCMV. Suppression of DTH to MCMV caused by intravenously injected MCMV was reduced in mice given 50 mg/kg cyclophosphamide, but not in those given 200 mg/kg. Deoxyguanosine had no effect on the induction of DTH to MCMV.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error