The stability of P85, encoded by ts110 Moloney murine sarcoma virus, was studied. P85 was found to turn over more rapidly at 39 °C than 33 °C in two different cell lines. One of these is a non-producer cell clone (6m2) which appears only to express P85 at 33 °C. The other cell line (206-2IC) produces P85 at both 33 °C and 39 °C, although in lower amounts at the higher temperature. Both cell lines exhibit the normal morphological phenotype following a shift to the restrictive temperature. These data suggest that the presence of P85 alone is insufficient to cause transformation, and that some function(s) associated with the molecule may be heat-labile.


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