1887

Abstract

Summary

Neurovaccinia virus propagated in the presence of bromodeoxyuridine loses the capacity to produce necrosis in the skin of rabbits. Mechanisms underlying this loss were studied. The population under study consisted predominantly of virus particles capable of producing necrosis (RS) and a small portion of particles which had lost this capacity (RS ). An RS clone isolated from the population induced an inhibitor of interferon type in rabbit skin, which markedly inhibited reproduction of RS virus strains and consequently the capacity of these strains to produce necrosis.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-6-3-355
1970-03-01
2024-12-05
Loading full text...

Full text loading...

/deliver/fulltext/jgv/6/3/JV0060030355.html?itemId=/content/journal/jgv/10.1099/0022-1317-6-3-355&mimeType=html&fmt=ahah

References

  1. Bektemirov T. A., Gumennik A. E. 1967; Blocking of production and activity of interferon by an inhibitor induced by vaccinia virus. Problems of Virology 1:18 in Russian
    [Google Scholar]
  2. Chernos V. I., Apridonidze K. G. 1968; Preparation and properties of conditional-lethal mutants of pox viruses. All Union Conference on the Problems of Viral Vaccines, Moscow p. 73
    [Google Scholar]
  3. Fenner F. 1958; The biological characters of several strains of vaccinia, cowpox and rabbitpox viruses. Virology 5:502
    [Google Scholar]
  4. Ferrari W., Gessa G. L., Loddo B., Sehivo M. L. 1965; Decreased pathogenity for rabbit skin of IDU-resistant vaccinia virus. Virology 26:154
    [Google Scholar]
  5. Ghendon Yu. Z. 1965; On the ability of certain viruses to block the effect of interferon. Acta virologica 9:186
    [Google Scholar]
  6. Ghendon Yu. Z., Chernos V. I. 1964; Comparative study of genetic markers of some pox virus strains. Acta virologica 8:359
    [Google Scholar]
  7. Ghendon Yu. z., Chernos V. I., Rozina E. E. 1968; A study of genetic markers and variability of pox virus group. Internationales Symposium über Fragen des Pockenschutzes, Berlin p. 221
    [Google Scholar]
  8. Kit S., Dubs D. R., Piekarski L. J., Hsu T. C. 1963; Deletion of thymidine kinase activity from L cells resistant to bromodeoxyuridine. Experimental Cell Research 31:297
    [Google Scholar]
  9. Nagano J. 1967; Studies on virus inhibiting factor. Japanese Journal of Experimental Medicine 37:183
    [Google Scholar]
  10. Nagano J., Kojima J. 1958; Inhibition de l’infection vaccinale par un facteur liquide dans le tissu infecté par le virus homologue. Comptes rendus des séances de la Société de biologie 162:1627
    [Google Scholar]
  11. Porterfield J., Allison A. 1960; Studies with pox viruses by an improved plaque technique. Virology 10:233
    [Google Scholar]
  12. Westwood J., Phipps P., Boulter E. 1957; The titration of vaccinia virus on the chorioallantoic membrane of developing chick embryo. Journal of Hygiene 55:123
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-6-3-355
Loading
/content/journal/jgv/10.1099/0022-1317-6-3-355
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error