1887

Abstract

SUMMARY

After infection with Sendai virus or Newcastle disease virus (NDV) strain F, human osteosarcoma MG63 cells produced large amounts of interferon-β. Both interferon production and overall protein synthesis were strongly inhibited by hypertonic salt. Interferon mRNA synthesis, however, was little affected by hypertonic salt up to twice normal salt concentrations, although cellular RNA synthesis was inhibited under these conditions. The results are compared to those obtained with polyriboinosinic acid:polyribocytidylic acid copolymer [poly(rI).poly(rC)] inductions of MG63 cells.

Keyword(s): human , hypertonicity , interferon and mRNA
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-59-1-177
1982-03-01
2022-01-22
Loading full text...

Full text loading...

/deliver/fulltext/jgv/59/1/JV0590010177.html?itemId=/content/journal/jgv/10.1099/0022-1317-59-1-177&mimeType=html&fmt=ahah

References

  1. Atherton K. A., Burke D. C. 1975; Interferon induction by viruses and polynucleotides: a differential effect of camptothecin. Journal of General Virology 29:297–304
    [Google Scholar]
  2. Billiau A., Edy V. G., Heremans H., van Damme J., Desmyter J., Georgiades J. A., De Somer P. 1977; Human interferon: mass production in a newly established cell line, MG63. Antimicrobial Agents and Chemotherapy 12:11–15
    [Google Scholar]
  3. Cavalieri R. L., Havell E. A., Vilček J., Pestka S. 1977; Induction and decay of human fibroblast interferon messenger RNA. Proceedings of the National Academy of Sciences of the United States of America 74:4415–4419
    [Google Scholar]
  4. Colman A., Morser J. 1979; Export of proteins from oocytes of Xenopus laevis. Cell 17:517–526
    [Google Scholar]
  5. Garry R. F., Waite M. R. F. 1979; Na+ and K+ concentrations and the regulation of the interferon system in chick cells. Virology 96:121–128
    [Google Scholar]
  6. Hayes T. G., Yip Y. K., Vilček J. 1979; Le interferon production by human fibroblasts. Virology 98:351–363
    [Google Scholar]
  7. Meager A., Graves H. E., Bradshaw T. K. 1978; Stimulation of interferon yields from cultured human cells by calcium salts. FEBS Letters 87:303–307
    [Google Scholar]
  8. Meager A., Graves H. E., Shuttleworth J., Zucker N. 1979a; Interferon production: variation in yields from human cell lines. Infection and Immunity 25:658–663
    [Google Scholar]
  9. Meager A., Graves H. E., Walker J. R., Burke D. C., Swallow D. M., Westerveld A. 1979b; Somatic Cell genetics of human interferon production in human-rodent cell hybrids. Journal of General Virology 45:309–321
    [Google Scholar]
  10. Morser J., Flint J., Meager A., Graves H., Baker P. N., Colman A., Burke D. C. 1979; Characterization of interferon messenger RNA from human lymphoblastoid cells. Journal of General Virology 44:231–244
    [Google Scholar]
  11. Pang R. H. L., Hayes T. G., Vilček J. 1980; Le interferon mRNA from human fibroblasts. Proceedings of the National Academy of Sciences of the United States of America 77:5341–5345
    [Google Scholar]
  12. Sehgal P. B., Tamm I. 1980; Synthesis, structure and function of poly(I) poly(C)-induced human fibroblast interferon mRNA. Annals of the New York Academy of Sciences 350:405–412
    [Google Scholar]
  13. Sehgal P. B., Dobberstein B., Tamm I. 1977; Interferon messenger RNA content of human fibroblasts during induction: shutoff and superinduction of interferon production. Proceedings of the National Academy of Sciences of the United States of America 74:3409–3413
    [Google Scholar]
  14. Sehgal P. B., Lyles D. S., Tamm I. 1978; Superinduction of human fibroblast interferon production: further evidence for increased stability of interferon mRNA. Virology 89:186–198
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-59-1-177
Loading
/content/journal/jgv/10.1099/0022-1317-59-1-177
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error