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The activity of 2′–5′ oligo(A) synthetase has been measured both in control and interferon-treated lymphoid cells. While control or interferon-treated Raji and Namalwa cells exhibit low activity of the 2′–5′ oligo(A) synthetase, the activity of this enzyme is increased 20-fold when Daudi cells are treated with the same dose of human interferon. The same enzyme is induced by interferon in R3HR-1 cells to a lesser extent.
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