1887

Abstract

SUMMARY

The activity of 2′–5′ oligo(A) synthetase has been measured both in control and interferon-treated lymphoid cells. While control or interferon-treated Raji and Namalwa cells exhibit low activity of the 2′–5′ oligo(A) synthetase, the activity of this enzyme is increased 20-fold when Daudi cells are treated with the same dose of human interferon. The same enzyme is induced by interferon in R3HR-1 cells to a lesser extent.

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1982-01-01
2022-01-18
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References

  1. Adams A., Strander H., Cantell K. 1975; Sensitivity of the Epstein-Barr virus transformed human lymphoid cell lines to interferon. Journal of General Virology 28:207–217
    [Google Scholar]
  2. Balkwill F., Walting D., Taylor-Papadimitriou J. 1978; Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast. International Journal of Cancer 22:258–265
    [Google Scholar]
  3. De Ley M., Billiau A., De Somer P. 1979; Interferon induced synthesis of a 63000 dalton protein in mouse cells. Biochemical and Biophysical Research Communications 89:701–705
    [Google Scholar]
  4. Friedman R. M. 1977; Antiviral activity of interferon. Bacteriological Reviews 41:543–567
    [Google Scholar]
  5. Gresser L., Brouty-Boye D., Thomas M. T., Coelho A. M. 1970; Interferon and cell division. I. Inhibition of the multiplication of mouse leukemia L1210 cells in vitro by interferon preparations. Proceedings of the National Academy of Sciences of the United States of America 66:1052–1058
    [Google Scholar]
  6. Hovanessian A. G., Brown R. E., Kerr I. M. 1977; Synthesis of a low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells. Nature, London 268:537–540
    [Google Scholar]
  7. Hovanessian A. G., Wood J., Meurs E., Montagnier L. 1979; Increased nuclease activity in cells treated with pppA2′p5′A2′p5′A. Proceedings of the National Academy of Sciences of the United States of America 76:3261–3265
    [Google Scholar]
  8. Kerr I. M., Brown R. E. 1978; pppA2′p5′A2′p5′A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells. Proceedings of the National Academy of Sciences of the United States of America 75:256–260
    [Google Scholar]
  9. Kerr I. M., Brown R. E., Hovanessian A. G. 1977; Nature of inhibitor of cell-free protein synthesis formed in response to interferon and double-stranded RNA. Nature, London 268:540–542
    [Google Scholar]
  10. Lebleu B., Sen G. C., Shaila S., Cabrer B., Lengyel P. 1976; Interferon, double-stranded RNA, and protein phosphorylation. Proceedings of the National Academy of Sciences of the United States of America 73:3107–3111
    [Google Scholar]
  11. Marcus P. I., Terry T. M., Levine S. 1975; Interferon action. II. Membrane-bound alkaline ribonuclease activity in chick embryo cells manifesting interferon-mediated interference. Proceedings of the National Academy of Sciences of the United States of America 72:182–186
    [Google Scholar]
  12. Meldolesi M. F., Triedman R. M., Kohn L. D. 1977; An interferon-induced increase in cyclic AMP levels precedes the establishment of the antiviral state. Biochemical and Biophysical Research Communications 79:239–246
    [Google Scholar]
  13. Roberts W. K., Hovanessian A., Brown R. E., Clemens M. J., Kerr I. M. 1976; Interferon-mediated protein kinase and low-molecular-weight inhibitor of protein synthesis. Nature, London 264:477–480
    [Google Scholar]
  14. Schmidt A., Chernajovsky Y., Shulman L., Federman H., Berissi H., Revel M. 1979; An interferon-induced phosphodiesterase degrading (2′-5′) oligoisoadenylate and the C-C-A terminus of t-RNA. Proceedings of the National Academy of Sciences of the United States of America 76:4788–4792
    [Google Scholar]
  15. Sonnabend J. A., Friedman R. M. 1973 In Interferons and Interferon Inducers pp 201–239 Edited by Finder N. B. New York: Elsevier/North-Holland;
    [Google Scholar]
  16. Stark G. R., Dower W. J., Shimke R. T., Brown R. E., Kerr I. M. 1979; 2-5A synthetase: assay, distribution and variation with growth or hormone status. Nature, London 278:471–473
    [Google Scholar]
  17. Strander H., Einhorn S. 1977; Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture. International Journal of Cancer 19:468–473
    [Google Scholar]
  18. Werhaegen M., Divizia M., Vandenbussche P., Kuwata T., Content J. 1980; Abnormal behavior of interferon-induced enzymatic activities in an interferon-resistant cell line. Proceedings of the National Academy of Sciences of the United States of America 77:4479–4483
    [Google Scholar]
  19. Williams B. R. G., Golgher R. R., Kerr I. M. 1979; Activation of a nuclease by pppA2′p5′A2′p5′ in intact cells. FEBS Letters 105:47–52
    [Google Scholar]
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