1887

Abstract

SUMMARY

Two preparations of yellow fever vaccine (17D) were studied by clonal analysis. From one (17D-England) three types of clones were isolated, each differentiated by plaque size in Vero cells and virulence for intracerebrally inoculated mice: small plaque (SP) and large plaque (LP) clones were lethal, whereas medium plaque (MP) clones failed to kill at doses up to 10 p.f.u. Analysis of 24 randomly selected clones showed the original vaccine to be a mixture of predominantly MP and SP variants; 58% and 42% respectively. A single passage in suckling mice modified this composition to 90% SP and 10% LP variants. The response of six inbred strains of mice to intracerebral inoculation of the MP variant varied from complete resistance to complete susceptibility. From another 17D substrain (17D-South Africa) two types of variants were isolated (a SP avirulent type and a LP type of intermediate virulence), both different from the previously described variant.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-56-2-363
1981-10-01
2022-01-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/56/2/JV0560020363.html?itemId=/content/journal/jgv/10.1099/0022-1317-56-2-363&mimeType=html&fmt=ahah

References

  1. Bonnel P. H. 1956; International regulation of yellow fever vaccination. In Yellow Fever Vaccination pp 193–210 World Health Organization Monograph Series No. 30
    [Google Scholar]
  2. Burfoot C., Young P. A., Finter N. B. 1977; The thermal stability of a new stabilized 17D yellow fever vaccine. Journal of Biological Standardization 5:173–179
    [Google Scholar]
  3. Collier W. A., Deroever-Bonnet H., Hoekstra J. 1959; A neurotropic variety of the vaccine strain 17D. Tropical and Geographical Medicine 11:80–92
    [Google Scholar]
  4. Darnell N. B., Koprowski H., Lagerspetz K. 1974; Genetically determined resistance to infection with group B arboviruses. I. Distribution of the resistance gene among various mouse populations and characteristics of gene expression in vivo. Journal of Infectious Diseases 129:240–247
    [Google Scholar]
  5. Dougherty R. M. 1964; Animal virus titration techniques. In Techniques in Experimental Virology pp 169–224 Edited by Harris R. J. C. London and New York: Academic Press;
    [Google Scholar]
  6. Fox J. P. 1943; Non-fatal infection in mice following intracerebral inoculation of yellow fever virus. Journal of Experimental Medicine 77:507–520
    [Google Scholar]
  7. Fox J. P., Penna M. A. 1943; Behaviour of 17D yellow fever virus in rhesus monkeys: relation to substrain, dose, and neural or extra-neural inoculation. American Journal of Hygiene 38:152–172
    [Google Scholar]
  8. Fox J. P., Lennette E. H., Manso C., Souza Aguilar J. R. 1942; Encephalitis in man following vaccination with 17D yellow fever virus. American Journal of Hygiene 36:117–142
    [Google Scholar]
  9. Hallauer C. 1959; Zuchtung von Gelbfiebervirus in menschlichen Explantaten. Archiv für die gesamte Virusforschung 9:428–441
    [Google Scholar]
  10. Sabin A. B. 1952; Nature of inherited resistance to viruses affecting the nervous system. Proceedings of the National Academy of Sciences of the United States of America 38:540–546
    [Google Scholar]
  11. Schindler R., Hallauer C. 1963; Priifung von Gelbfiebervirus varianten aus menschlichen Gewebekulturen in Affenversuch. Archiv für die gesamte Virusforschung 13:345–359
    [Google Scholar]
  12. Stuart T. 1956; Reactions following vaccination against yellow fever. In Yellow Fever Vaccination pp 143–189 World Health Organization Monograph Series No. 30
    [Google Scholar]
  13. Theiler M. 1951; The virus. In Yellow Fever pp 39–136 Edited by Strode G. New York: McGraw-Hill;
    [Google Scholar]
  14. Theiler M., Smith H. H. 1937; Effect of prolonged cultivation in vitro upon pathogenicity of yellow fever virus. Journal of Experimental Medicine 65:767–786
    [Google Scholar]
  15. World Health Organization 1971 Technical Reports series No. 479 WHO Expert Committee on Yellow Fever. Third Report.:
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-56-2-363
Loading
/content/journal/jgv/10.1099/0022-1317-56-2-363
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error