1887

Abstract

Summary

Acute and recurrent herpes simplex was studied after infection in the ear of two outbred and five inbred strains of mice. In all strains tested there was clinical evidence of infection, and a proportion of the mice became latently infected in the cervical ganglia. Six weeks after infection, when attempts were made to induce recurrent disease by stripping the ears of the mice with cellophane tape, a proportion of animals of each strain developed recurrent disease, characterized by erythema in the skin. At monthly intervals thereafter, the ears were stripped again and, on each occasion, a proportion of the animals developed recurrent disease, with the exception of Balb/c mice. The different reaction of Balb/c and other inbred strains might prove useful in studies on the mechanisms of control of recurrent herpes simplex.

Keyword(s): herpes simplex , latency , mice and recurrence
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-55-1-31
1981-07-01
2024-10-11
Loading full text...

Full text loading...

/deliver/fulltext/jgv/55/1/JV0550010031.html?itemId=/content/journal/jgv/10.1099/0022-1317-55-1-31&mimeType=html&fmt=ahah

References

  1. Baringer J. R. 1975; Herpes simplex virus infection of nervous tissue in animals and man. Progress in Medical Virology 20:1–26
    [Google Scholar]
  2. Blyth W. A., Hill T. J., Field H. J., Harbour D. A. 1976; Reactivation of herpes simplex virus infection by ultraviolet light and possible involvement of prostaglandins. Journal of General Virology 33:547–550
    [Google Scholar]
  3. Blyth W. A., Harbour D. A., Hill T. J. 1980; Effect of immunosuppression on recurrent herpes simplex in mice. Infection and Immunity 29:902–907
    [Google Scholar]
  4. Brown S. M., Subak-sharpe J. H., Warren K. G., Wroblewska Z., Koprowski H. 1979; Detection by complementation of defective or uninducible (herpes simplex type 1) virus genomes latent in human ganglia. Proceedings of the National Academy of Sciences of the United States of America 76:2364–2368
    [Google Scholar]
  5. Cabrera C. V., Wohlenberg C., Openshaw H., Rey-mendez M., Puga A., Notkins A. L. 1980; Herpes simplex virus DNA sequences in the CNS of latently infected mice. Nature, London 288:288–290
    [Google Scholar]
  6. Clarke G. M., Cooke D. 1978 In A Basic Course in Statistics p 244 London: Edward Arnold;
    [Google Scholar]
  7. Hill T. J., Blyth W. A. 1976; An alternative theory of herpes simplex recurrence and a possible role for prostaglandins. Lancet 1:397–399
    [Google Scholar]
  8. Hill T. J., Field H. J., Blyth W. A. 1975; Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease. Journal of General Virology 28:341–353
    [Google Scholar]
  9. Hill T. J., Blyth W. A., Harbour D. A. 1978; Trauma to the skin causes recurrence of herpes simplex in the mouse. Journal of General Virology 39:21–28
    [Google Scholar]
  10. Hurd J., Robinson T. W. E. 1977; Herpes simplex: aspects of reactivation in a mouse model. Journal of Antimicrobial Chemotherapy 3:99–106
    [Google Scholar]
  11. Lopez C. 1975; Genetics of natural resistance to herpesvirus infections in mice. Nature, London 258:152–153
    [Google Scholar]
  12. Mclennan J. L., Darby G. K. 1980; Herpes simplex virus latency: the cellular location of virus in dorsal root ganglia and the fate of the infected cell following virus activation. Journal of General Virology 51:233–243
    [Google Scholar]
  13. Roizman B. 1965; An inquiry into the mechanism of recurrent herpes infections of man. Perspectives in Virology 4:283–301
    [Google Scholar]
  14. Russell A. S., Schlaut J. 1975; HL-A transplantation antigens in subjects susceptible to recrudescent herpes labialis. Tissue Antigens 6:257–261
    [Google Scholar]
  15. Schwartz J., Whetsell W. O., Elizan T. S. 1978; Latent herpes simplex virus infection of mice. Infectious virus in homogenates of latently infected dorsal root ganglia. Journal of Neuropathology and Experimental Neurology 37:45–55
    [Google Scholar]
  16. Scriba M. 1975; Herpes simplex virus infection in guinea-pigs: an animal model for studying latent and recurrent herpes simplex virus infection. Infection and Immunity 12:162–165
    [Google Scholar]
  17. Scriba M. 1976; Recurrent genital herpes simplex virus (HSV) infection of guinea pigs. Medical Microbiology and Immunology 162:201–208
    [Google Scholar]
  18. Stevens J. G., Cook M. L., Jordan M. C. 1975; Reactivation of latent herpes simplex virus after pneumococcal pneumonia in mice. Infection and Immunity 11:635–639
    [Google Scholar]
  19. Underwood G. E., Weed S. D. 1974; Recurrent cutaneous herpes simplex in hairless mice. Infection and Immunity 10:471–474
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-55-1-31
Loading
/content/journal/jgv/10.1099/0022-1317-55-1-31
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error