1887

Abstract

Summary

HPA 39 is a tungsto-antimoniate compound, closely related to the mineral consensed ion HPA 23, from which it differs only by the presence of a potassium instead of a sodium ion inside the central cage. A single parenteral injection of HPA 39 on the same day as virus inoculation decreased the splenomegaly induced by Friend virus in DBA/2 mice and protected 90% of the infected animals against leukaemia. It also lowered the virus content in spleen extracts compared to untreated animals. The efficiency of treatment with HPA 39 on leukaemic mice at a late stage of the disease suggested that the compound may act at the cellular level as well as by inducing virus growth inhibition. HPA 39 also induced an early decrease of peripheral blood reticulocytes, and of the most differentiated erythroblasts in the bone marrow 1 day after injection of the compound. Mineral condensed ions therefore appear to have multiple biological effects both and .

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-55-1-17
1981-07-01
2024-04-27
Loading full text...

Full text loading...

/deliver/fulltext/jgv/55/1/JV0550010017.html?itemId=/content/journal/jgv/10.1099/0022-1317-55-1-17&mimeType=html&fmt=ahah

References

  1. Bassin R. H., Philipps L. A., Cramer H. J. 1971; Transformation of mouse 3T3 cells by murine sarcoma viruses: release of virus-like particles in the absence of replicating murine leukaemia helper virus. Proceedings of the National Academy of Sciences of the United States of America 68:1520–1524
    [Google Scholar]
  2. Chirigos M. A., Luber E., March R. W., Pettigrew H. 1965; Antiviral chemotherapeutic assay with Friend leukemia virus in mice. Cancer Chemotherapy Report 45:29–33
    [Google Scholar]
  3. Fredrickson T., Tambourin P., Jasmin C., Smadja F. 1975; The target cell of polycythemia inducing Friend virus. Studies with Myleran. Journal of the National Cancer Institute 55:443–446
    [Google Scholar]
  4. Jasmin C., Rosenfeld C., Chomette J., Piton C. 1968; Action de l’actinomycine D sur la maladie de Friend. Revue Fran false d’Etudes Cliniques et Biologiques 13:292–296
    [Google Scholar]
  5. Jasmin C., Chermann J. C., Raynaud M., Werner G., Raybaud N., Sinoussi F., Boy-Loustau C. 1974a; In vivo and in vitro antiviral activity of the mineral condensed heteropolyanion 5-tungsto-2-antimoniate. In Proceedings of the Congress of the International Society of Chemotherapy vol 2 pp 956–962 Edited by Daikos G. K. Athens: Urban & Schwarzenberg;
    [Google Scholar]
  6. Jasmin C., Chermann J. C., Herve G., Teze A., Souchay P., Boy-Loustau C., Raybaud N., Sinoussi F., Raynaud M. 1974b; In vivo inhibition of murine leukemia and sarcoma viruses by the heteropolyanion 5-tungsto-2-antimoniate. Journal of the National Cancer Institute 53:469–474
    [Google Scholar]
  7. Larnicol N., Augery Y., Jasmin C., Montero J. L., Imbach J. L. 1977; Effect of nitrosourea derivative RPCNU (ICIG 1163) on the development of Friend leukemia in mice. Biomedicine 26:176–181
    [Google Scholar]
  8. Rowe W. P., Brodsky I. 1959; A graded response assay for the Friend leukemia virus. Journal of the National Cancer Institute 23:1239–1248
    [Google Scholar]
  9. Seidel H. J., Opitz U. 1979a; Effect of actinomycin D and busulphan on stem cells in normal and Friend virus infected mice. Blüt 38:349–360
    [Google Scholar]
  10. Seidel H. J., Opitz U. 1979b; Hematopoietic stem cells in Friend murine leukemia virus infected mice undergoing chemotherapy: remission and relapse of erythropoietin-independent erythropoiesis induced by hydroxyurea. Journal of the National Cancer Institute 62:531–536
    [Google Scholar]
  11. Tambourin P. E., Wendling F. 1975; Target cell for oncogenic action of polycythaemia-inducing Friend virus. Nature, London 256:320–322
    [Google Scholar]
  12. Tsiang H., Atanasiu P., Chermann J. C., Jasmin C. 1978; Inhibition of rabies virus in vitro by ammonium 5-tungsto-2-antimoniate. Journal of General Virology 40:665–668
    [Google Scholar]
  13. Werner G. H., Jasmin C., Chermann J. C. 1976; Effect of ammonium 5-tungsto-2-antimoniate on encephalomyocarditis and vesicular stomatitis virus infections in mice. Journal of General Virology 31:59–64
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-55-1-17
Loading
/content/journal/jgv/10.1099/0022-1317-55-1-17
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error