1887

Abstract

Summary

Viruses from six antigenic groups of arthropod-borne viruses [Crimean-Congo haemorrhagic fever (CCHF), Nairobi sheep disease (NSD), Qalyub (QYB), Sakhalin (SAK), Dera Ghazi Khan (DGK) and Hughes (HUG) serogroups], some previously categorized as bunyavirus-like viruses and others previously ungrouped, have recently been assembled by serological analyses into a new genus of viruses ( genus) in the Bunyaviridae. Molecular studies of the virion RNA and viral polypeptides have been undertaken with representative members of the different serogroups [Hazara (HAZ) and Congo (CON) viruses, CCHF group; Dugbe (DUG) virus, NSD group; QYB, Omo and Bandia (BDA) viruses, QYB group; Avalon (AVA) virus, SAK group; DGK and Abu Mina (AM) viruses, DGK group; and HUG virus, HUG group]. In agreement with a recent study of QYB virus and in part agreement with an earlier report on DUG virus, the results of these molecular analyses indicate that nairoviruses have: (i) three virion RNA species (large, L, medium, M, and small, S) with apparent mol. wt. of 4.1 × 10 to 4.9 × 10, 1.5 × 10 to 1.9 × 10 and 0.6 × 10 to 0.7 × 10 respectively; (ii) a 48 × 10 to 54 × 10 mol. wt. nucleocapsid (N) polypeptide; and (iii) two external glycopolypeptides, 72 × 10 to 84 × 10 mol. wt. (G1) and 30 × 10 to 40 × 10 mol. wt. (G2). Cross-immune precipitation analyses have confirmed that viruses in the genus share antigenic determinants and are antigenically distinct from representative members of the and genera (Bunyaviridae).

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1981-07-01
2024-07-25
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