1887

Abstract

Summary

Temperature-sensitive () mutations occurring in three genes 1, 2 and 7, and 1, 5 and 7 were found in two cold-adapted () attenuated influenza virus strains A/Leningrad/9/37/46 (H0N1) and A/Leningrad/134/17/57 (H2N2) respectively. The recombinants, obtained by crossing these cold-adapted strains with virulent influenza virus strains, had different genome structures and inherited from one to six genes from the cold-adapted parents. Tests of reactogenicity of recombinants in volunteers showed all the recombinants to be non-reactogenic irrespective of the number of genes inherited from the cold-adapted parent.

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/content/journal/jgv/10.1099/0022-1317-53-2-215
1981-04-01
2019-11-15
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-53-2-215
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