1887

Abstract

SUMMARY

Pre-treatment of L cells with 750 units/ml of mouse interferon depressed the yield of interferon when the cells were treated with Newcastle disease virus (NDV). The refractory state persisted for more than 5 days. Nucleated fragments (karyoplasts) obtained by cytochalasin B-induced enucleation were made from such interferon pre-treated cells; cells reconstituted from these karyoplasts produced less interferon in response to NDV than did cells reconstituted from karyoplasts derived from untreated cells. The source of the enucleated cytoplasm (cytoplasts) used in the cellular reconstitutions did not affect the yields of interferon.

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1980-08-01
2024-05-07
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References

  1. Atkins G. J., Johnston M. D., Westmacott L. M., Burke D. C. 1974; Induction of interferon in chick cells by temperature sensitive mutants of Sindbis Virus. Journal of General Virology 25:381–390
    [Google Scholar]
  2. Bausek G. H., Merigan T. C. 1970; Two mechanisms of cell resistance to repeated stimulation of interferon. Proceedings of the Society for Experimental Biology and Medicine 134:672–676
    [Google Scholar]
  3. Burke D. C., Veomett G. 1977; Enucleation and reconstruction of interferon-producing cells. Proceedings of the National Academy of Sciences of the United States of America 74:3391–3395
    [Google Scholar]
  4. Colby B. 1977; Interferon systems -an overview. In Interferons and Their Actions pp 1–11 Edited by Stewart W. E. Cleveland: CRC Press;
    [Google Scholar]
  5. Field A. K., Tytell A. A., Lampson G. P., Hilleman M. R. 1967; Inducers of interferon synthesis and host resistance. II. Multistranded synthesis polynucleotide complexes. Proceedings of the National Academy of Sciences of the United States of America 58:1004–1010
    [Google Scholar]
  6. Golgher R. R., Paucker K. 1973; Blocking of interferon production by chromatographically purified L-cell interferon. Proceedings of the Society for Experimental Biology and Medicine 142:167–174
    [Google Scholar]
  7. Havell E. A. 1977; Cellular regulatory mechanisms controlling synthesis of interferons. In Interferons and Their Actions pp 37–48 Edited by Stewart W. E. Cleveland: CRC Press;
    [Google Scholar]
  8. Heller E. 1963; Enhancement of chikungunya virus replication and inhibition of interferon production by actinomycin D. Virology 21:652–656
    [Google Scholar]
  9. Ho M. H., Armstrong J. A. 1975; Interferon. Annual Review of Microbiology 29:132–161
    [Google Scholar]
  10. Ho M., Breinig M. C. 1965; Metabolic determinants of interferon formation. Virology 25:331–339
    [Google Scholar]
  11. Iwakura Y., Yonehara S., Kawade Y. 1978; Purification of mouse L-cell interferon: essentially pure preparations with associated cell growth inhibitory activity. Journal of Biological Chemistry 253:5074–5079
    [Google Scholar]
  12. Johnston M. D., Burke D. C. 1973; Interferon induction by viruses: molecular requirements. In Selective Inhibitors of Viral Functions pp 123–148 Edited by Carter W. A. Cleveland: CRC Press;
    [Google Scholar]
  13. Kohase M., Vilcek J. 1977; Regulation of human interferon production stimulated with poly(I) -poly(C): correlations between shut-off and hyporesponsiveness to reinduction. Virology 76:47–54
    [Google Scholar]
  14. Lampson G. P., Tytell A. A., Field A. K., Nemes M. H., Hilleman M. R. 1967; Inducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum. Proceedings of the National Academy of Sciences of the United States of America 58:782–789
    [Google Scholar]
  15. Lockrt R. Z. Jun 1963; Production of an interferon by L cells infected with Western equine encephalomyelitis virus. Journal of Bacteriology 85:556–566
    [Google Scholar]
  16. Paucker K., Boxaca M. 1967; Cellular resistance to induction of interferon. Bacteriological Reviews 31:145–156
    [Google Scholar]
  17. Prescott D. M., Myerson D., Wallace J. 1972; Enucleation of mammalian cells with cytochalisin B. Experimental Cell Research 71:480–485
    [Google Scholar]
  18. Radke K. L., Colby C. J. R., Krider H. M., Prescott D. M. 1974; Establishment and maintenance of the interferon-induced antiviral state: studies in enucleated cells. Journal of Virology 13:623–630
    [Google Scholar]
  19. Stewart W. E., Gosser L. B., Lockart R. Z. 1971; Distinguishing characteristics of the interferon responses of primary and continuous mouse cell cultures. Journal of General Virology 13:35–50
    [Google Scholar]
  20. Stringfellow D. A. 1976; Murine leukemia: depressed response to interferon induction correlated with a serum hyporeactive factor. Infection and Immunity 13:392–398
    [Google Scholar]
  21. Stringfellow D. A. 1977; Production of interferon protein: hyporesponsiveness. Texas Reports on Biology and Medicine 35:126–131
    [Google Scholar]
  22. Tan V. H., Armstrong J. A., Ke Y. H., Ho M. 1970; Regulation of cellular interferon production by antimetabolites. Proceedings of the National Academy of Sciences of the United States of America 67:464–471
    [Google Scholar]
  23. Veomett G., Shay J., Hough P. V. C., Prescott D. M. 1976; Large-scale enucleation of mammalian cells. Methods in Cell Biology 8:1–6
    [Google Scholar]
  24. Vilcek J., Kohase M. 1977; Regulation of interferon production: cell culture studies. Texas Reports on Biology and Medicine 35:57–62
    [Google Scholar]
  25. Vilcek J., Ng M. H. 1971; Post-transcriptional control of interferon synthesis. Journal of Virology 7:588–594
    [Google Scholar]
  26. Wagner R. R. 1964; Inhibition of interferon biosynthesis by actinomycin D. Nature, London 204:49–50
    [Google Scholar]
  27. Youngner J. S., Steinbring W. R., Taube S. E. 1965; Influence of inhibitors of protein synthesis on interferon formulation in mice. Virology 27:541–550
    [Google Scholar]
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