1887

Abstract

SUMMARY

The properties of two temperature-sensitive mutants 18 and 19 of adenovirus type 5 were studied. It was demonstrated that they had a defect such that they failed to assemble virus and showed defective processing of infected cell polypeptides at the restrictive temperature. Analysis, after protease digestion, of the virions produced at the permissive temperature by SDS PAGE, and of the substrate availability of the mutants to the virus protein kinase suggested that polypeptide VI was defective in these mutants.

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/content/journal/jgv/10.1099/0022-1317-43-3-531
1979-06-01
2021-10-19
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