1887

Abstract

SUMMARY

Nude mice injected subcutaneously with normal uninfected BHK 21 cells or HeLa cells regularly develop large, rapidly-growing tumours at the subcutaneous site of inoculation. However, these same tumour cell lines when persistently infected with VSV or other enveloped RNA viruses are either rejected or form small nodules in nude mice. This rejection phenomenon probably involves some type of immunocyte since heavily-irradiated nude mice (500 rads) cannot reject persistently infected cells but develop large, rapidly-growing tumours which shed virus and defective interfering virus (DI) and which do not exhibit the lymphocytic infiltration observed in the nodules of unirradiated mice given persistently infected cells. Finally, it was possible to select a subline of BHK 21-VSV carrier cells which regularly produces large rapidly-growing tumours in normal unirradiated nude mice, although all these carrier cells express virus antigen and shed large amounts of mature infectious virus and DI both and .

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-42-3-609
1979-03-01
2022-01-16
Loading full text...

Full text loading...

/deliver/fulltext/jgv/42/3/JV0420030609.html?itemId=/content/journal/jgv/10.1099/0022-1317-42-3-609&mimeType=html&fmt=ahah

References

  1. Bonmassar E. 1978; Radioresistant inhibition of tumor growth. In Symposium on the Use of Athymic (Nude) Mice in Cancer Research (in the press) Edited by Houchens D., Ovejera T. New York: Gustav Fisher;
    [Google Scholar]
  2. Freedman V. H., Shin S. 1974; Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium. Cell 3:355–359
    [Google Scholar]
  3. Haller O., Hanson M., Kiessling R., Wigzell H. 1977; Role of non-conventional natural killer cells in resistance against syngeneic tumor cells in vivo. Nature, London 270:609–611
    [Google Scholar]
  4. Holland J. J., Villarreal L. P. 1974; Persistent noncytocidal vesicular stomatitis virus infections mediated by defective T particles that suppress virion transcriptase. Proceedings of the National Academy of Sciences of the United States of America 71:2956–2960
    [Google Scholar]
  5. Holland J. J., Villarreal L. P., Welsh R. M., Oldstone M. B. A., Kohne D., Lazzarini R., Scolnick E. 1976; Long-term persistent vesicular stomatitis virus and rabies virus infection of cells in vitro. Journal of General Virology 33:193–211
    [Google Scholar]
  6. Klinger H. P., Shin S., Freedman V. H. 1976; Enhanced anchorage independence and tumorigenicity of aneuploid Chinese hamster cells with nearly doubled chromosome complements. Cytogenetics and Cell Genetics 17:185–199
    [Google Scholar]
  7. Koene R., Gerlag J., Jansen J., Hagemann J., Wijdeveld P. 1974; Rejection of skin grafts in the nude mouse. Nature, London 251:69–70
    [Google Scholar]
  8. Lefkowits I. 1978 In Symposium on the Use of Athymic (Nude) Mice in Cancer Research (in the press) Edited by Houchens D., Ovejera T. New York: Gustav Fisher;
    [Google Scholar]
  9. Maguire H. Jr, Outzen H. C., Custer R. P., Prehn R. T. 1976; Brief communication: invasion and metastasis of a xenogeneic tumor in nude mice. Journal of the National Cancer Institute 57:439–442
    [Google Scholar]
  10. Miller R. G., Schilling R. M., Phillips R. A. 1977; Requirements for non T-cells in the generation of cytotoxic T lymphocytes (CTL) in vitro: II. Characterization of the active cells in the spleen of nude mice. Journal of Immunology 118:166–174
    [Google Scholar]
  11. Minato N., Bloom B. R., Jones C., Holland J. J., Reid L. M. 1979; Mechanism of rejection of virus persistently infected tumour cells by athymic nude mice. Journal of Experimental Medicine (in the press)
    [Google Scholar]
  12. Pantelouris E. M. 1968; Absence of thymus in a mouse mutant. Nature, London 217:370
    [Google Scholar]
  13. Reid L., Shin S. 1978; Transplantation of endocrine tumors in nude mice. In The Nude Mouse in Experimental and Clinical Research pp 313–351 Edited by Fogh J., Giovanella B. New York: Academic Press;
    [Google Scholar]
  14. Rygaard J. 1973 In Thymus and Self: Immunobiology of the Mouse Mutant Nude New York: John Wiley and Sons;
    [Google Scholar]
  15. Stiles C. D., Desmond W. D., Sato G., Saier M. H. Jun 1976; Relationship of cell growth behavior in vitro to tumorigenicity in athymic nude mice. Cancer Research 36:3300–3305
    [Google Scholar]
  16. Villarreal L. P., Holland J. J. 1976; RNA synthesis in BHK 21 cells persistently infected with vesicular stomatitis virus and rabies virus. Journal of General Virology 33:213–224
    [Google Scholar]
  17. Yamada T., Hatano M. 1972; Lowered transplantability of cultured tumour cells by persistent infection with paramyxovirus. (HVJ) GANN: The Japanese Journal of Cancer Research 63:647–655
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-42-3-609
Loading
/content/journal/jgv/10.1099/0022-1317-42-3-609
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error