1887

Abstract

SUMMARY

The influence of araT on the synthesis of HSV of types 1 and 2 including a TK(-) variant, on the activity of the dThd and the dCyd kinases and on the incorporation of radioactivity into insoluble or soluble material after infection was studied. AraT inhibited different parameters of the replication of a TK(-) variant; it is possibly phosphorylated by enzymes other than the deoxypyrimidine kinase and therefore it is less selectively phosphorylated than dThd. The mode of action of araT on herpes replication must be studied in more detail.

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/content/journal/jgv/10.1099/0022-1317-42-2-435
1979-02-01
2024-05-10
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References

  1. Aswell J. F., Allen G. P., Jamieson A. T., Campbell D. E., Gentry G. A. 1977; Antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro. Antimicrobial Agents and Chemotherapy 12:243–254
    [Google Scholar]
  2. Bittlingmaier K., Schneider D., Falke D. 1975; Uptake of (3H)-thymidine and cell DNA-synthesis during the early multiplication phase of herpes virus hominis in BHK cells. Biochimica et Biophysica Acta 407:384–391
    [Google Scholar]
  3. Bittlingmaier K., Schneider D., Falke D. 1977; Thymidine transport in herpes virus hominis type 1 and 2 infected BHK 21 cells. Journal of General Virology 35:159–173
    [Google Scholar]
  4. Doberson M. J., Jerkofsky M., Greer S. 1976; Enzymatic basis for the selective inhibition of varicellazoster virus by 5-halogenated analogues of deoxycytidine. Journal of Virology 20:478–486
    [Google Scholar]
  5. Dundaroff S., Falke D. 1972; Thymidine-, uridine- and choline-kinase in rabbit kidney cells infected with herpesvirus hominis type 1 and 2. Archiv für die gesamte Virusforschmg 38:56–66
    [Google Scholar]
  6. Dundaroff S., Just I., Falke D. 1975; Influence of double infections on the induction of thymidine kinase by UV-irradiated herpes simplex virus type i and 2 and pseudorabies virus. Archives of Virology 49:117–126
    [Google Scholar]
  7. Gentry G. A., Aswell J. F. 1975; Inhibition of herpes simplex virus replication by araT. Virology 65:294–296
    [Google Scholar]
  8. Jamieson A. T., Gentry G. A., Subak-Sharpe J. H. 1974; Induction of both thymidine- and deoxycytidine-kinase-activity by herpes viruses. Journal of General Virology 24:481–492
    [Google Scholar]
  9. Just I., Dundaroff S., Falke D., Wolf H. U. 1975; Regulation by thymidine-monophosphate and other nucleotides of thymidine kinase activity in extracts from primary rabbit kidney cells infected by HSV types l and 2. Journal of General Virology 29:69–80
    [Google Scholar]
  10. Miller R. L., Iltis J. P., Rapp F. 1977; Differential effect of arabinofuranosylthymine on the replication of human herpes viruses. Journal of Virology 23:679–684
    [Google Scholar]
  11. Müller W. E. G., Zahn R. K., Beyer R., Arendes J. 1979a; Arabinosyl nucleosides. XII. Influence of arabinofuranosyl-thymine on growth of L5178y cells. Chemical-Biological Interactions (in the press)
    [Google Scholar]
  12. Müller W. E. G., Zahn R. K., Arendes J. 1979b; Arabinosyl nucleosides. XIII. Influence of arabinofuranosyl-thymine on DNA-, RISA- and protein-synthesizing systems in vitro. Chemical-Biological Interactions (in the press)
    [Google Scholar]
  13. De Rudder J., Garilhe M. P. 1965; Inhibitory effect of some nucleosides on the growth of various human viruses in tissue culture. Antimicrobial Agents and Chemotherapy 259:578–584
    [Google Scholar]
  14. Underwood G. E., Wisner C. A., Weed S. D. 1964; Cytosine arabinoside (CA) and other nucleosides in herpesvirus infection. Archives of Opthalmology 72:505–512
    [Google Scholar]
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