1887

Abstract

Summary

Various double-stranded RNAs of either synthetic or natural origin have been compared for their interferon-inducing potency in human skin fibroblasts ‘primed’ with interferon and ‘superinduced’ with cycloheximide and actinomycin D. While natural double-stranded RNAs (extracted from either mycophage, f bacteriophage or reovirus) and alternating copolymers [(A-U).(A-U), (G-C).(G-C), (I-C).(I-C)] proved relatively less effective in inducing interferon than (I).(C), a variety of synthetic homopolymer pairs, including (I).(brC), (I).(sC), (A).(rT) and (A).(U), showed an interferon-inducing activity comparable to that of (I).(C).

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/content/journal/jgv/10.1099/0022-1317-37-3-619
1977-12-01
2019-10-20
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-37-3-619
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