1887

Abstract

SUMMARY

We have studied prospectively 178 subjects exposed to hepatitis B and 120 haemodialysed patients for the presence of HB antigen, e antigen and DNA polymerase as well as for anti-HB and anti-HB antibodies. The results suggest that the DNA polymerase assay enables us to diagnose hepatitis B earlier than the radioimmunoassay for HB and that DNA polymerase might be present in the blood in the absence of HB in cases of confirmed hepatitis B. A positive correlation between e antigen and DNA polymerase was observed in 83% of the patients on haemodialysis who developed hepatitis B but only in 9% of normal patients developing the same disease.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-36-1-217
1977-07-01
2024-05-10
Loading full text...

Full text loading...

/deliver/fulltext/jgv/36/1/JV0360010217.html?itemId=/content/journal/jgv/10.1099/0022-1317-36-1-217&mimeType=html&fmt=ahah

References

  1. Alter H. J., Sceff L. B., Kaplan P. M., McAuliffe V. J., Wright E. C., Gerin J. L., Purcell R. H., Holland P. V., Zimmerman H. J. 1976; Type B hepatitis: the infectivity of blood for e antigen and DNA polymerase after accidental needlestick exposure. New England Journal of Medicine 295:909–913
    [Google Scholar]
  2. Bradley D. W., Maynard J. E., Berquist K. R., Krushak D. H. 1974; Hepatitis B and serum polymerase activities in chimpanzees. Nature, London 251:356–357
    [Google Scholar]
  3. Cappel R., Schluederberg A., Gifford R., Horstmann D. 1974; Characterization of a human acute phase protein found in association with rubella virus infection. Journal of Experimental Medicine 139:497–511
    [Google Scholar]
  4. Eleftheriou N., Thomas H. C., Heathcote J., Sherlock S. 1975; Incidence and clinical significance of e antigen and antibody in acute and chronic liver disease. Lancet ii:1171–1173
    [Google Scholar]
  5. Kaplan P. M., Greenman R. L., Gerin J. L., Purcell R. H., Robinson W. S. 1973; DNA polymerase associated with human hepatitis B antigen. Journal of Virology 12:995–1005
    [Google Scholar]
  6. Krugman S., Hoofnagle J. H., Gerety R. J., Kaplan P. M., Gerin J. L. 1974; Viral hepatitis type B. DNA polymerase activity and antibody to hepatatis B core antigen. New England Journal of Medicine 290:1231–1235
    [Google Scholar]
  7. Nielsen J. O., Dietricson O., Juhl E. 1974; Incidence and meaning of ‘e’ determinant among hepatitis B positive patients with acute and chronic liver diseases. Lancet ii:913–915
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-36-1-217
Loading
/content/journal/jgv/10.1099/0022-1317-36-1-217
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error