1887

Abstract

SUMMARY

The effects of actinomycin D on the production of genomic RNA, messenger RNA and protein in measles virus-infected cells were investigated. It was found that whereas high concentrations of the drug inhibited genome synthesis, the production of messenger RNA was unaffected and in some cases enhanced. These effects were shown, at least in part, to be due to a secondary effect of the drug which caused an inhibition of virus-specific protein synthesis.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-34-2-391
1977-02-01
2022-01-21
Loading full text...

Full text loading...

/deliver/fulltext/jgv/34/2/JV0340020391.html?itemId=/content/journal/jgv/10.1099/0022-1317-34-2-391&mimeType=html&fmt=ahah

References

  1. Anderson C. D., Atherton I. G. 1964; Effect of Actinomycin D on measles virus growth and interferon production. Nature, London 303:670
    [Google Scholar]
  2. Barry R. D. 1964; Effects of inhibitors of nucleic acid synthesis on the production of myxoviruses. In Cellular Biology of Myxovirus Infections pp 51–75 Ciba Foundation Symposium. Churchill Ltd;
    [Google Scholar]
  3. Carter C., Schluederberg A., Black F. L. 1973; Viral RNA synthesis in measles-infected cells. Virology 53:379–383B
    [Google Scholar]
  4. De Jong J. C., Winkler K. C. 1970; The multiplication of measles virus in human amnion cells in vitro. Journal of General Virology 7:13–17
    [Google Scholar]
  5. Dubois M. F. 1975; Effect of Actinomycin D on the replication of parainfluenza 3 virus, strain EA 102. In Negative Strand Virus p 523 Edited by Mahy B. W. J., Barry R. D. New York: Academic Press;
    [Google Scholar]
  6. East J. L., Kingsbury D. W. 1971; Mumps virus replication in chick embryo lung cells: properties of ribonucleic acids in virions and infected cells. Journal of Virology 8:161–173
    [Google Scholar]
  7. Granoff A., Kingsbury D. W. 1964; Effect of actinomycin D on the replication of Newcastle disease and influenza viruses. In Cellular Biology of Myxovirus Infections pp 96–119 Ciba Foundation Symposium. Churchill Ltd;
    [Google Scholar]
  8. Kelly D. C., Avery R. J., Dimmock N. J. 1974; Failure of an influenza virus to initiate infection in enucleate BHK cells. Journal of Virology 13:1155–1161
    [Google Scholar]
  9. Kiley M. P., Payne F. E. 1974; Replication of measles virus: continued synthesis of nucleocapsid RNA and increased synthesis of mRNA in the presence of cycloheximide. Journal of Virology 14:758–764
    [Google Scholar]
  10. Matumoto M. 1966; Multiplication of measles virus in cell cultures. Bacteriological Reviews 30:152–176
    [Google Scholar]
  11. Mirchamsy H., Rapp F. 1969; Role of interferon in replication of virulent and attenuated strains of measles virus. Journal of General Virology 4:513–522
    [Google Scholar]
  12. Norrby E., Chiarini A., Marusyk H. 1970; Measles virus variants; intracellular appearance and biological characteristics of virus products. In The Biology of Large RNA Viruses Edited by Barry R. D., Mahy B. W. J. New York: Academic Press;
    [Google Scholar]
  13. Schluederberg A., Chavanich S. 1974; The role of the nucleus in measles virus replication. Medical Microbiology and Immunology 160:85–90
    [Google Scholar]
  14. Schluederberg A., Williams C. A., Black F. L. 1972; Inhibition of measles virus replication and RNA synthesis by actinomycin D. Biochemical and Biophysical Research Communications 48:657–661
    [Google Scholar]
  15. Winston S. H., Rustigian R., Bratt M. A. 1973; Persistent infection of cells in culture by measles virus. III. Comparison of virus-specific RNA synthesized in primary and persistent infection in HeLa cells. Journal of Virology 11:926–932
    [Google Scholar]
  16. Zhdanov V. M. 1975; Integration of viral genomes. Nature, London 256:471–473
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-34-2-391
Loading
/content/journal/jgv/10.1099/0022-1317-34-2-391
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error