1887

Abstract

SUMMARY

cultured mouse peritoneal macrophages are inefficient host cells for both alpha and flaviruses tested. Production of infectious virus ceased 6 to 24 h after infection, except for virulent and avirulent SF strains. This limited growth is unrelated to interferon production. No correlation was found between the LD of different virus strains for mice and the virus yields of infected macrophages therefrom. When macrophages from SF immunized mice were inoculated with SF or EEE, a cytopathic effect occurred, while the multiplication of SF, but not of EEE, was decreased. Virus multiplication in proteose peptone induced macrophages was enhanced for SF strains only. These results are discussed in relation to the virulence of several arboviruses for mice.

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1977-02-01
2024-04-26
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References

  1. Allison A. C. 1974; On the role of mononuclear phagocytes in immunity against viruses. Progress in Medical Virology 18:15–31
    [Google Scholar]
  2. Avila F. A., Schultz R. M., Tompkins W. A. F. 1972; Specific macrophage immunity to vaccinia virus: macrophage virus interaction. Infection and Immunity 6:9
    [Google Scholar]
  3. Bradish C. J., Allner K., Fitzgeorge R. 1975; Immunomodification and the expression of virulence in mice by defined strains of Semliki Forest virus: the effects of myocrisin and L-asparaginase. Journal of General Virology 28:239–250
    [Google Scholar]
  4. Clarke D. H., Casals J. 1958; Techniques for hemagglutination and hemagglutination inhibition with arthropod-borne viruses. American Journal of Tropical Medicine and Hygiene 7:561–573
    [Google Scholar]
  5. Eustatia J. M., Maase E., Van Helden P., Van Der Veen J. 1972; Viral replication in mouse macrophages. Archiv für die gesamte Virusforschung 39:376–380
    [Google Scholar]
  6. Goodman G. T., Koprowski H. 1962; Study of the mechanism of innate resistance to virus infection. Journal of Cellular and Comparative Physiology 59:333–373
    [Google Scholar]
  7. Hansen B., Koprowski H., Baron S., Buckler C. H. E. 1969; Interferon mediated natural resistance of mice to arbo 3 virus infection. Microbios 1B:51–58
    [Google Scholar]
  8. Heessen F. W. A. 1975; The role of macrophages in persistent adenovirus infections. Doctors thesis chapter 4 pp 64–67 Nijmegen: Krips Repro Meppel;
    [Google Scholar]
  9. Hirsch M. S., Zisman B., Allison A. C. 1970; Macrophages and age dependent resistance to herpes simplex virus in mice. Journal of Immunology 104:1160–1165
    [Google Scholar]
  10. Hronovsky V., Plaisner V., Benda R. 1975; A modified plaque method for arboviruses on plastic panels. Acta Virologica 19:150–154
    [Google Scholar]
  11. Johnson R. T. 1964; The pathogenesis of herpes virus encephalitis. II. A cellular basis for the development of resistance with age. Journal of Experimental Medicine 120:359–374
    [Google Scholar]
  12. Lagwinska E., Stuart C. C., Adles C., Schlesinger S. 1975; Replication of lactic dehydrogenase virus and Sindbis virus in mouse peritoneal macrophages. Virology 65:204–214
    [Google Scholar]
  13. Mcfarland H. F. 1974; In vitro studies of cell-mediated immunity in an acute viral infection. Journal of Immunology 113:173–180
    [Google Scholar]
  14. Olson L. C., Sithisarn P., Djinawi N. K. 1975; Role of macrophages in Wesselsbron and Germiston virus infections of mice. Journal of Infectious Diseases 131:119–127
    [Google Scholar]
  15. Reed L. J., Muench H. 1938; A simple method of estimating fifty percent endpoints. American Journal of Hygiene 27:493–495
    [Google Scholar]
  16. Schultz R. M., Woan M. C., Tompkins W. A. F. 1974; Macrophage immunity to vaccinia virus: factors affecting macrophage immunity in vitro. Journal of the Reticuloendothelial Society 16:37–47
    [Google Scholar]
  17. Sheagren J. H., Simon H. B., Tuazon C. V., Mehrota P. 1975 In Mononuclear Phagocytes in Immunity, Infection and Pathology 1st ed chapter 42 pp 654–658 Edited by van Furth R. Oxford, London: Blackwell Scientific Publications;
    [Google Scholar]
  18. van Furth R. 1975; Modulation of monocyte production. In Mononuclear Phagocytes in Immunity, Infection and Pathology 1st ed chapter 10 pp 161–174 Edited by van Furth R. Oxford, London: Blackwell Scientific Publications;
    [Google Scholar]
  19. van Furth R., Cohn Z. A., Hirsch J. G., Humphrey J. H., Spector W. G., Langevoort H. L. 1972; The mononuclear phagocyte system: a new classification of macrophages, monocytes and their precursor cells. Bulletin of the World Health Organization 46:845–852
    [Google Scholar]
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