1887

Abstract

SUMMARY

A simian type-C virus has been detected in cultures chronically infected with Mason-Pfizer monkey virus (M-PMV). Simultaneous budding of M-PMV and type-C virus particles from the same cells was observed in cultures incubated at 37 or 40 °C. However, the frequency of such cells was greater in cultures grown at 40 °C. Although clusters of type-C viral buds were seen at the surface of the cells, extracellular mature type-C particles in cell pellets or concentrated virus preparations were very rarely found. The increase in frequency of type-C buds was found to be transitory since cultures adapted to growing at the high temperature demonstrated budding type-C particles only occasionally. Cultures producing type-C buds were found to contain, in addition to M-PMV antigens, serological activity with polyvalent antisera produced against multiple structural components of endogenous baboon virus (BV) or simian sarcoma virus (SiSV). The reactivity, however, was found not to be serologically related to the major SiSV p28 core protein.

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/content/journal/jgv/10.1099/0022-1317-30-1-11
1976-01-01
2022-01-25
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References

  1. Ahmed M., Mayyasi S. A., Chopra H. C., Zelljadt I., Jensen E. M. 1971; Mason Pfizer monkey virus isolated from spontaneous mammary carcinoma of a female monkey. 1. Detection of virus antigens by immunodiffusion, immunofluorescent and virus agglutination techniques. Journal of the National Cancer Institute 46:1325–1334
    [Google Scholar]
  2. Ahmed M., Schidlovsky G., Korol W., Vidrine J. G., Cicamenc J. L. 1974; Occurrence of Mason-Pfizer monkey virus in healthy rhesus monkeys. Cancer Research 34:3504–3508
    [Google Scholar]
  3. Calafat J. 1968; Virus particles of the B and C type associated with mouse mammary tumors. Journal of Microscopy 7:841–848
    [Google Scholar]
  4. Chopra H. C., Mason M. M. 1970; A new virus in a spontaneous mammary tumor of a rhesus monkey. Cancer Research 30:2081–2086
    [Google Scholar]
  5. Chopra H. C., Zelljadt I., Jensen E. M., Woodside N. J. 1971; Infectivity of cell cultures by a virus isolated from a mammary carcinoma of a rhesus monkey. Journal of the National Cancer Institute 46:127–137
    [Google Scholar]
  6. Dalton A. J. 1955; A chrome-osmium fixative for electron microscopy. Anatomical Record 121:281
    [Google Scholar]
  7. Dalton A. J., Haguenau F., Moloney J. B. 1964; Further electron microscopic studies on the morphology of the Moloney agent. Journal of the National Cancer Institute 33:255–275
    [Google Scholar]
  8. Dmochowskl L., Grey C. E., Langford P. L., Williams W. C., Sykes J. A., Yound E. L., Migliore P. J. 1967; Viral factors in mammary tumorigenesis. In Carcinogenesis: A Broad Critique (University of Texas M. D. Anderson Hospital and Tumor Institute at Houston), pp. 211–256 Baltimore: The Williams & Wilkins Co;
    [Google Scholar]
  9. Dmochowskl L., Langford P. L., Williams W. C., Liebelt A. G., Liebelt R. A. 1968; Electron micrOscopic and bioassay studies on milk from mice of high and low mammary cancer and high and low leukemia strains. Journal of the National Cancer Institute 40:1339–1368
    [Google Scholar]
  10. Feldman D. G., Gross L. 1967; Electron microscopic study of the distribution of the mouse leukemia virus (Gross) in genital organs of the virus-infected C3Hf mice and Ak mice. Cancer Research 27:1513–1527
    [Google Scholar]
  11. Hall W. T., Anderson W. F., Evans V. J. 1967; In vitro and in vivo observations on a murine C-type virus. Journal of Virology 1:1238–1254
    [Google Scholar]
  12. Hilgers J., William W. C., Myers B., Dmochowski L. 1971; Detection of antigens of the mouse mammary tumor (MTV) and murine leukemia virus (MuLV) in cells of cultures derived from mammary tumors of mice of several strains. Virology 45:470–483
    [Google Scholar]
  13. Jensen E. M., Zelljadt L., Chopra H. C., Mason M. M. 1970; Isolation and propagation of a virus from spontaneous mammary carcinoma of a rhesus monkey. Cancer Research 30:2388–2393
    [Google Scholar]
  14. Kalter S. S., Helmke R. J., Panigel M., Heberling R. L., Felsburg P. J., Axelrod L. R. 1973; Observations of apparent C-type particles in baboon (Papio cynocephalus) placenta. Science, New York 179:1332–1333
    [Google Scholar]
  15. Kramarsky B., Sarkar N. H., Moore D. H. 1971; Ultrastructural comparison of a virus from a rhesus monkey mammary carcinoma with four oncogenic RNA viruses. Proceedings of the National Academy of Sciences of the United States of America 68:1603–1607
    [Google Scholar]
  16. Lasfargues E. Y., Kramarsky B., Sarkar N. H., Lasfargues J. C., Pillsburn N., Moore D. H. 1970a; Stimulation of mammary tumor virus production in a mouse mammary tumor cell line. Cancer Research 30:1108–1117
    [Google Scholar]
  17. Lasfargues E. Y., Pillsbury N., Lasfargues J. C., Moore D. H. 1970b; Release of leukemia C-particles from murine cell lines infected with Bittner virus-containing inocula. Cancer Research 30:167–178
    [Google Scholar]
  18. Luft J. H. 1961; Improvements in epoxy resin embedding methods. Journal of Biophysics, Biochemistry and Cytology 9:409–414
    [Google Scholar]
  19. Manning J. S., Hackett A. J. 1972; Morphological and biophysical properties of the Mason-Pfizer monkey virus. Journal of the National Cancer Institute 48:417–422
    [Google Scholar]
  20. Mason M. M., Bogden A. E., Ilievsky V., Esber H. J., Baker J. R., Chopra H. C. 1972; History of a rhesus monkey adenocarcinoma containing virus particles resembling oncogenic rat viruses. Journal of the National Cancer Institute 48:1323–1331
    [Google Scholar]
  21. Mayer R. J., Smith R. G., Gallo R. C. 1974; Reverse transcriptase in normal rhesus monkey placenta. Science, New York 185:864–867
    [Google Scholar]
  22. Rongey R. W., Hlavackova A., Lara S., Estes J., Gardner M. B. 1973; Type B and C RNA virus in breast tissue and milk of wild mice. Journal of the National Cancer Institute 50:1581–1589
    [Google Scholar]
  23. Schidlovsky G., Ahmed M. 1973; C-type virus particles in rhesus monkey placentas and fetal tissues. Journal of the National Cancer Institute 51:225–233
    [Google Scholar]
  24. Sherr C., Lieber M., Benveniste R., Todaro G. 1974; Endogenous baboon type-C virus (M7): biochemical and immunologic characterization. Virology 58:492–503
    [Google Scholar]
  25. Venable J. H., Coggeshall R. 1965; A simplified lead citrate stain for use in electron microscopy. Journal of Cell Biology 25:407–408
    [Google Scholar]
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