1887

Abstract

Summary

Serological cross-reactions were detected between four avian influenza viruses and a human A 2/57 virus and between an avian (TURKEY/CANADA/63) and an equine (EQUI 2/MIAMI/63) strain. The reactions were detected by strain-specific complement fixation tests and neuraminidase inhibition but not by haemagglutination-inhibition. Specific antiserum to the neuraminidase of an A 2/57 virus also reacted with the four avian viruses showing that it was the neuraminidase antigen on the avian and human A 2 virus that were antigenically closely related. The possibility that these viruses may have arisen by recombination between human and avian influenza viruses in nature is discussed.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-3-2-201
1968-09-01
2021-10-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/3/2/JV0030020201.html?itemId=/content/journal/jgv/10.1099/0022-1317-3-2-201&mimeType=html&fmt=ahah

References

  1. Ada G. L., Lind P. E., Laver W. G. 1963; An immunological study of avian, viral and bacterial neuraminidase based on specific inhibition of enzyme by antibody. J. gen. Microbiol 32:225
    [Google Scholar]
  2. Aminoff D. 1961; Methods for the quantitative estimation of TV-acetylneuraminic acid and their application to hydrolysates of sialomucoids. Biochem. J 81:384
    [Google Scholar]
  3. Fazekas de St Groth S. 1963; Steric inhibition: Neutralization of a virus borne enzyme. Ann. N. Y. Acad. Sci 103:674
    [Google Scholar]
  4. Graham E. R. B. 1961; Some aspects of the structures of the carbohydrate moiety of fetuin. Aust. J. Sci 24:140
    [Google Scholar]
  5. Harboe A., Borthne B., Berg K. 1961; Antibody against normal egg material resulting from influenza vaccination. Acta path, microbiol. scand 53:95
    [Google Scholar]
  6. Kilbourne E. D., Laver W. G., Schulman J. L., Webster R. G. 1968; Antiviral activity of antiserum specific for an influenza virus neuraminidase. 1. In vitro effects. (In preparation)
    [Google Scholar]
  7. Kilbourne E. D., Lief F. S., Shulman J. L., Jahiel R. I., Laver W. G. 1967; Antigenic hybrids of influenza viruses and their implications. Perspectives Virol 6:87
    [Google Scholar]
  8. Laver W. G. 1964; Structural studies on the protein subunits from three strains of influenza virus. J. molec. Biol 9:109
    [Google Scholar]
  9. Laver W. G., Kilbourne E. D. 1966; Identification in a recombinant influenza virus of structural proteins derived from both parents. Virology 30:493
    [Google Scholar]
  10. Lief F. S., Cohen D. 1965; Equine influenzaStudies on the virus and of antibody patterns in convalescent, interepidemic and post vaccination sera. Am. J. Epidem 82:225
    [Google Scholar]
  11. Lief F. S., Henle W. 1959; Methods and procedures for use of complement fixation technique in type-and strain-specific diagnosis of influenza. Bull. Wld Hlth Org 20:411
    [Google Scholar]
  12. Pereira H. G., Pereira M. S., Law V. G. 1964; Antigenic variants of influenza A 2 virus. Bull. Wld Hlth Org 31:129
    [Google Scholar]
  13. Pereira H. G., Rinaldi A., Nardelli L. 1967a; Antigenic variation amongst avian influenza A viruses. Bull. Wld Hlth Org 37:553
    [Google Scholar]
  14. Pereira H. G., Tumova B., Webster R. G. 1967b; Antigenic relationship between influenza A viruses of human and avian origins. Nature, Lond 215:982
    [Google Scholar]
  15. Pereira H. G., Lang G., Olesink O. M., Snoevenbos G. H., Roberts D. H., Easterday B. C. 1966; New antigenic variants of avian influenza A viruses. Bull. Wld Hlth Org 35:799
    [Google Scholar]
  16. Takatsy G. 1955; The use of spiral loops in serological and virological micromethods. Acta microbiol. hung 3:191
    [Google Scholar]
  17. Tumova B., Pereira H. G. 1965; Genetic interaction between influenza A viruses of human and animal origin. Virology 27:253
    [Google Scholar]
  18. Tumova B., Pereira H. G. 1968; Antigenic relationships between influenza A viruses of human and animal origins. Bull. Wld Hlth Org (In the Press)
    [Google Scholar]
  19. Warren L. 1959; The thiobarbituric acid assay of sialic acids. J. biol. Chem 334:1971
    [Google Scholar]
  20. Webster R. G., Laver W. G. 1967; Preparation and properties of antibody directed specifically against the neuraminidase of influenza virus. J. Immun 99:49
    [Google Scholar]
  21. Webster R. G., Laver W. G., Kilbourne E. D. 1968; Reactions of antihaemagglutinin and antineuraminidase antibodies with two A0–A2 recombinant influenza viruses containing different amounts of A 2 neuraminidase. Virology (In the Press)
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-3-2-201
Loading
/content/journal/jgv/10.1099/0022-1317-3-2-201
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error